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Keywords: ulcerative colitis
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Clin Sci (Lond) (2022) 136 (4): 291–307.
Published: 23 February 2022
...Liping Liang; Le Liu; Wanyan Zhou; Chenghai Yang; Genghui Mai; Haolin Li; Ye Chen Ulcerative colitis (UC) is majorly associated with dysregulation of the dynamic cross-talk among microbial metabolites, intestinal epithelial cells, and macrophages. Several studies have reported the significant role...
Includes: Supplementary data
Clin Sci (Lond) (2021) 135 (4): 597–611.
Published: 18 February 2021
...Dandan Dou; Jinghui Liang; Xiangyu Zhai; Guosheng Li; Hongjuan Wang; Liying Han; Lin Lin; Yifei Ren; Shilian Liu; Chuanyong Liu; Wei Guo; Jingxin Li Background: Ulcerative colitis (UC) is a type of inflammatory bowel disease (IBD) that is associated with immune dysfunction. Recent studies have...
Includes: Supplementary data
Clin Sci (Lond) (2018) 132 (20): 2169–2174.
Published: 19 October 2018
...Xavier Escoté In a recent issue of Clinical Science , Prieto-Vicente et al. [ Clin. Sci. (2018) 132 , 985–1001] have smartly demonstrated a potential new use of cardiotrophin-1 (CT-1) to treat and palliate an inflammatory bowel disease such as ulcerative colitis. In that work, authors report...
Clin Sci (Lond) (2018) 132 (11): 1155–1168.
Published: 09 June 2018
... to this work. 19 02 2018 13 03 2018 14 03 2018 14 03 2018 © 2018 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2018 Crohn’s disease inflammatory bowel disease ulcerative colitis Crohn’s disease (CD) and ulcerative colitis...
Includes: Supplementary data
Clin Sci (Lond) (2017) 131 (24): 2933–2945.
Published: 08 December 2017
...Xinrui Wang; Yonggang Zhu; Manli Zhang; Jie Hou; Hongjuan Wang; Yanfang Jiang; Haifeng Wang; Pujun Gao B-cell immunity participates in the pathogenesis of ulcerative colitis (UC). The immune balance between follicular regulatory T (TFR) cells and follicular helper T (TFH) cells is important...
Includes: Supplementary data
Clin Sci (Lond) (2015) 129 (3): 271–280.
Published: 08 May 2015
... and function, in IBD. A significant increase in IL-34 mRNA and protein expression was seen in inflamed mucosa of patients with CD (Crohn's disease) and patients with UC (ulcerative colitis) compared with the uninvolved areas of the same patients and normal controls. IL-34 was up-regulated in LPMCs (lamina...
Includes: Supplementary data
Clin Sci (Lond) (2010) 118 (12): 707–715.
Published: 30 March 2010
...) interleukin T-cell ulcerative colitis tumour necrosis factor (TNF) CD (Crohn's disease) and UC (ulcerative colitis) are the major chronic IBDs (inflammatory bowel diseases) in humans. Although the aetiology of both CD and UC is unknown, evidence has accumulated to demonstrate that IBD-related...
Clin Sci (Lond) (2004) 107 (4): 331–341.
Published: 24 September 2004
... investigated the cellular and molecular mechanisms of interactions between intestinal mucosal cells and the resident luminal bacteria in healthy individuals and patients with ulcerative colitis and Crohn's disease. Mechanisms by which the intestinal mucosa is able to avoid pro-inflammatory responses...
Clin Sci (Lond) (1998) 94 (5): 473–478.
Published: 01 May 1998
...Jack Satsangi; Miles Parkes; Derek P. Jewell; John I. Bell 1. The aetiology of the chronic inflammatory bowel diseases, Crohn's disease and ulcerative colitis, is uncertain. Studies of specific environmental factors and immune dysfunction have provided little insight into disease pathogenesis. 2...
Clin Sci (Lond) (1997) 92 (3): 307–313.
Published: 01 March 1997
... of myeloperoxidase than infective diarrhoea. As a consequence, the median ratio of lactoferrin/myeloperoxidase excretion (both expressed as ng/mg of protein) for inflammatory bowel disease was 7.5 (range 3.5–21.3) with similar values for ulcerative colitis ( n = 18) and Crohn's disease ( n = 14) compared with only...
Clin Sci (Lond) (1995) 89 (5): 521–526.
Published: 01 November 1995
...Francesc Casellas; Michel Papo; Francisco Guarner; María Antolín; Rosa María Segura; José Ramón Armengol; Juan-Ramón Malagelada 1. To investigate the role of interleukin-1β in chronic ulcerative colitis, we quantified interleukin-1β steady-state release into the colonic lumen. 2. We studied 26...
Clin Sci (Lond) (1994) 86 (5): 619–626.
Published: 01 May 1994
...T. D. Wardle; L. A. Turnberg 1. Biopsies of colonic mucosa from patients with ulcerative colitis liberated more interleukin-1β, prostaglandin E 2 , leukotriene C 4 and platelet-activating factor into the medium in which they were cultured than biopsies from patients with irritable bowel syndrome...
Clin Sci (Lond) (1993) 85 (5): 623–627.
Published: 01 November 1993
... the impaired β-oxidation induced by NaHS. Methionine equally improved CO 2 and ketone body production, suggesting a global reversal of the action of sulphide. 5. Sulphide-induced oxidative changes closely mirror the impairment of β-oxidation observed in colonocytes of patients with ulcerative colitis...
Clin Sci (Lond) (1993) 84 (4): 381–386.
Published: 01 April 1993
... outcome. 3. IgM, but not IgG, lipocortin-I antibody levels were elevated in patients with ulcerative colitis and Crohn's disease compared with healthy control subjects. In patients with Crohn's disease not taking corticosteroids, IgM lipocortin-I antibody levels were directly related to disease activity...
Clin Sci (Lond) (1992) 83 (5): 623–626.
Published: 01 November 1992
...A. H. Raouf; H. H. Tsai; N. Parker; J. Hoffman; R. J. Walker; Jonathan M. Rhodes 1. Normal colonic mucin is heavily sulphated and this increases its resistance to degradation by bacterial enzymes. Any defect in mucus sulphation could therefore be important in the pathogenesis of ulcerative colitis...
Clin Sci (Lond) (1992) 82 (4): 447–454.
Published: 01 April 1992
... = 3). Biopsies (3-4 mm diameter) were obtained from 7-15 cm proximal to the anal margin Key words: bacteroides, mucus, sulphatase, ulcerative colitis. Correspondence: Dr H. H. Tsai, Department of Medicine, University of Liverpool, PO Box 147, Liverpool L69 3BX, U.K 448 H. H. Tsai e t al. at the end...
Clin Sci (Lond) (1992) 82 (3): 273–275.
Published: 01 March 1992
... levels of anti-neutrophil-activating peptide-1/interleukin-8 antibodies in patients with active ulcerative colitis [62.9 (3.4–239) ng/ml] than in patients with active Crohn's disease [5.9 (2.1–18.10) ng/ml; P <0.001] or in control subjects [6.1 (3.2–15.8) ng/ml; P <0.001]. 4. Neutrophil-activating...
Clin Sci (Lond) (1988) 75 (3): 277–283.
Published: 01 September 1988
...C. C. Ainley; J. Cason; L. K. Carlsson; B. M. Slavin; R. P. H. Thompson 1. The zinc contents of plasma, erythrocytes, polymorphonuclear leucocytes and mononuclear leucocytes from 18 normal control subjects, 31 patients with Crohn's disease and 15 patients with ulcerative colitis were measured. 2...
Clin Sci (Lond) (1988) 74 (1): 71–78.
Published: 01 January 1988
... in neutrophils could not account for the differences observed. 28 5 1987 19 6 1987 © 1970 The Biochemical Society and the Medical Research Society 1970 bacterial glycosidases Crohn's disease glycoconjugate glycoprotein mucin mucus sialic acid sialidases ulcerative colitis...
Clin Sci (Lond) (1987) 73 (4): 361–364.
Published: 01 October 1987
...Sergio Pacheco; Keith Hillier; Colin Smith 1. Colonic mucosa from 19 patients with ulcerative colitis, eight with Crohn's disease and 14 controls were analysed for arachidonic acid (C20:4), linoleic acid (C18:2), oleic acid (C18:1), stearic acid (C18:0) and palmitic acid (C16:0). 2. Gas–liquid...
Clin Sci (Lond) (1985) 69 (2): 177–184.
Published: 01 August 1985
... and its derivatives in vitro may suggest that NK activity is not a major pathogenic mechanism in ulcerative colitis. Any inhibitory effect on cellular immune function of indomethacin does not necessarily reflect an effect of cyclo-oxygenase inhibition. 5 3 1985 13 3 1985 © 1985...
Clin Sci (Lond) (1981) 61 (2): 229–234.
Published: 01 August 1981
...J. R. Clamp; G. Fraser; A. E. Read 1. Mucus samples obtained from colectomy colons from 10 patients with ulcerative colitis and four patients with Crohn's disease of the colon, together with samples from 10 normal postmortem colons, have been studied. 2. Two glycoprotein fractions were isolated...
Clin Sci (Lond) (1980) 59 (5): 389–391.
Published: 01 November 1980
...D. S. Rampton; R. D. Murdoch; G. E. Sladen 1. Rectal dialysis in vivo was used to assess rectal mucosal release of histamine in patients with ulcerative colitis and in control subjects. 2. Rectal mucosal histamine release was significantly increased in ulcerative colitis, whether the patients were...
Clin Sci (Lond) (1980) 58 (4): 295–300.
Published: 01 April 1980
...A. S. Mee; D. P. Jewell 1. The activity of a specific lysosomal marker enzyme N '-acetyl-β-d-glucosaminidase has been determined fluorimetrically in the monocytes and in the serum of patients with Crohn's disease and ulcerative colitis and compared with results obtained from healthy and disease...