...’; identification of the major physiological advanced glycation endproduct (AGE), MG-H1; physiological substrates of the unfolded protein response (UPR); new therapeutic agents—‘glyoxalase 1 (Glo1) inducers’; and a refined mechanism underlying the link of dysglycemia to the development of insulin resistance...

... Forward: CCACCACgCTCTTCTgTCTAC Reverse: AgggTCTgggCCATAgAACT TGF- β1 Mouse Forward: TgACgTCACTggAgTTgTACgg Reverse: ggTTCATgTCATggATggTgC AKI to CKD AST-120 ER stress indoxyl sulfate unfolded protein response Acute kidney injury (AKI) is characterized by a rapid decline...

... arising under conditions of chronic immunosuppression. We present the recent studies showing that CsA induces the unfolded protein response (UPR) in normal and transformed kidney cells. We examine how the UPR might be important, considering in particular the genomic analyses showing the existence...

...Toru Hosoi; Koichiro Ozawa Various stresses, which impair ER (endoplasmic reticulum) function, lead to an accumulation of unfolded or misfolded proteins. ER stress triggers many rescuer responses, including a UPR (unfolded protein response). Increasing evidence has suggested that ER stress...