...Hidekatsu YANAI; Mie MORIMOTO Physical activity is associated with beneficial changes in serum lipids, but exhaustive exercise has been suggested to increase oxidative stress. To test the effect of ascorbate (vitamin C) on serum lipids and the metabolism of urate, which is the most important...

... insulin for 4 h (50 m-units h −1 kg −1 ) on fractional renal sodium and urate excretion in 13 healthy subjects, using the euglycaemic clamp and lithium clearance technique, and performed a control experiment in eight of the subjects. 2. Insulin caused a decline in both fractional renal sodium excretion...

...Phulwinder K. Grover; Villis R. Marshall; Rosemary L. Ryall 1. Increasing the concentration of dissolved urate promotes calcium oxalate crystallization in urine from which Tamm-Horsfall mucoprotein, an inhibitor of calcium oxalate crystal aggregation, has almost completely been removed. This study...

...Phulwinder K. Grover; Rosemary L. Ryall; Villis R. Marshall 1. Increasing the concentration of dissolved urate promotes the crystallization of calcium oxalate from urine. The possibility was investigated that this effect may be caused by heterogeneous nucleation of calcium oxalate by particles...

... in cellular anion transport. 2. To determine whether this anomaly is restricted to oxalate alone, we studied erythrocyte transmembrane urate self-exchange in calcium-oxalate renal stone formers in whom urinary excretion of uric acid is frequently increased. 3. Abnormal urate self-exchange was found in 30...

...Phulwinder K. Grover; Rosemary L. Ryall; Villis R. Marshall 1. The effect of hyperuricosuria, simulated by increasing the concentration of dissolved urate, on the crystallization of calcium oxalate in human urine was examined. 2. Twenty urine samples were studied. Ten of these, designated type...

...Bengt Fellström; Monica Lindsjö; Bo G. Danielson; Sverker Ljunghall; Björn Wikström 1. The binding of heparin, chondroitin sulphate and the low molecular weight heparin analogue pentosan polysulphate to sodium urate and uric acid crystals was studied by the use of competitive binding technique...

... which causes accelerated purine synthesis de novo. This suggests that the primary abnormality may be a failure of the renal tubular net excretion of urate. 6 2 1984 1 3 1984 © 1984 The Biochemical Society and the Medical Research Society 1984 familial hyperuricaemic nephropathy...

... diet. 2. There was a 90% increase in urinary urate on HPD compared with LPD, whereas serum urate did not change consistently. 3. The urinary acid excretion increased by 200%, including a 100% increase in ammonium ion excretion. A fall in urine pH by 0.9 unit was also seen. 4. The calculated ion...

...P. C. Hallson; G. A. Rose; S. Sulaiman 1. Samples of fresh human urine were treated with immobilized uricase to lower urate concentration. Urate was added to yield low, normal and high urate samples. 2. Each sample was rapidly evaporated at pH 5.3 to standard osmolality and the yield of calcium...

...H. S. Diamond; A. D. Meisel 1. The effect on urate excretion of administration of probenecid and pyrazinamide was observed in normal subjects under control conditions and after induction of uricosuria by exogenous urate loading by ribonucleic acid feeding in seven subjects, by volume loading...

...P. F. Semple; W. Carswell; J. A. Boyle 1. A serial study of renal clearance of urate and inulin was made in thirteen normal women in early, mid and late pregnancy and 6–15 weeks after delivery. 2. The mean serum urate concentration was low in early and mid pregnancy but rose in late pregnancy...