... fatty acids (FFAs) and insulin resistance. However, the underlying mechanisms are not well established, especially the effect of uric acid (UA) on adipose tissue, a vital organ in regulating whole-body energy and FFA homeostasis. In the present study, we noticed that adipocytes from the white adipose...

...Richard O. Day; Bishoy Kamel; Diluk R.W. Kannangara; Kenneth M. Williams; Garry G. Graham Xanthine oxidoreductase (XOR) is the rate-limiting enzyme in purine catabolism and converts hypoxanthine to xanthine, and xanthine into uric acid. When concentrations of uric acid exceed its biochemical...

...W. S. WARING; A. CONVERY; V. MISHRA; A. SHENKIN; D. J. WEBB; S. R. J. MAXWELL Uric acid (UA) possesses free-radical-scavenging properties, and systemic administration is known to increase serum antioxidant capacity. However, it is not known whether this protects against oxidative stress...

... had significantly lower total antioxidant status than men, regardless of periodontal health. Periodontal disease is associated with reduced salivary antioxidant status and increased oxidative damage within the oral cavity. antioxidants gums oxidative injury periodontitis saliva uric acid...

...% higher in sportsmen than in controls ( P < 0.005). Accordingly, plasma hydrosoluble antioxidant levels (ascorbic acid and uric acid) were found to be significantly elevated in the soccer players ( P < 0.005). In addition, these subjects showed high concentrations of α-tocopherol in plasma compared...

...Marguerite Hatch; N. D. Vaziri 1. The potential contribution of enteric pathways to the extra-renal excretion of uric acid in chronic renal failure was evaluated by measuring [ 14 C]-urate and 36 Cl − transport in isolated, short-circuited segments of jejunum, ileum and distal colon from normal...

... transport. Our data suggest a decreased Na + /K + -ATPase activity in IGT, which may be of pathophysiological significance in relation to hypertension. 13 1 1987 17 2 1987 blood pressure glucose tolerance Na + /K + -ATPase platelet sodium uric acid © 1970 The Biochemical Society...

... tubular net excretion of urate. Key words: familial hyperuricaemic nephropathy, gout, Lesch-Nyhan syndrome, lymphocytes, mono- nuclear cells, purine synthesis de novo, purines, renal failure, urate, uric acid. Abbreviations: APRT, adenine phosphoribosyltrans- ferase; HPRT, hypoxanthine phosphoribosyltrans...

...B. Fellström; U. Backman; B. G. Danielson; K. Holmgren; S. Ljunghall; B. WikströM 1. Freshly voided urine from healthy subjects was pooled and ultrafiltered (10 000 daltons). The ultrafiltrable and the macromolecular portions were preincubated with calcium oxalate, uric acid and sodium urate...

...F. H. Messerli; E. D. Frohlich; G. R. Dreslinski; D. H. Suarez; G. G. Aristimuno 1. Glomerular filtration rate, renal and systemic haemodynamics and intravascular volume were measured in 20 established essential hypertensive patients classified according to serum uric acid level into two groups...

... or serum electrolytes, urea, creatinine, glucose, cholesterol and triglycerides, and in creatinine clearance, did not differ in the two groups of patients. 3. In patients taking tienilic acid a significant decrease in serum uric acid and an increase in urate clearance was observed, whereas in patients...

.... These results are in agreement with the inconstant acceleration of purine biosynthesis de novo in gouty patients as seen by others with measurement of [ 14 C]glycine incorporation into urinary uric acid. Clinical Science and Molecular Medicine (1978) 54, 595-601 Purine biosynthesis de novo by lymphocytes...

... phosphate and an increase in the urinary excretion of oxalic acid and uric acid, but these changes were all fully reversible when EHDP was stopped. 4. The average rate of stone formation per patient per year decreased from 2·4 to 0·2 during treatment with EHDP and remained low during the following 24 months...

...-quantitative estimates of the various components of urate transport in man. 24 11 1976 4 6 1977 © 1977 The Biochemical Society and the Medical Research Society 1977 diuretic hypouricaemia pyrazinamide renal transport tienilic acid uric acid Clinical Science and Molecular Medicine...

... Research Society 1976 kidney nephron reabsorption uric acid vasopressin Clinical Science and Molecular Medicine (1976) 51, 33-40. Effect of vasopressin on uric acid excretion: evidence for distal nephron reabsorption of urate in man A. MEISEL AND H. DIAMOND Departments of Medicine, State...

...L. E. Ramsay; R. M. Auty; C. E. Horth; D. Levine; J. R. Shelton; R. A. Branch 1. The relations between the concentration of plasma uric acid and urinary excretion of aldosterone, sodium and potassium, were studied in ten healthy males on a diet containing 160 mmol of sodium and 90 mmol of potassium...

...G. M. Danovitch; J. Weinberger; G. M. Berlyne 1. The results of studies of renal uric acid excretion in eleven patients with advanced chronic renal failure are presented. 2. The pyrazinamide suppression test was used to separate secretion from reabsorption of uric acid in the renal tubule. 3...