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Keywords: urine
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Articles
Dolores Olivares, Javier Perez-Hernandez, Maria J. Forner, Cristina Perez-Soriano, Maria C. Tormos, Guillermo T. Saez, Felipe J. Chaves, Josep Redon, Raquel Cortes
Journal:
Clinical Science
Clin Sci (Lond) (2018) 132 (5): 569–579.
Published: 15 March 2018
.... Therefore, the aim of the present study was to analyze whether urinary SIRT1 expression was altered in LN and whether SIRT1 values in urine could be valuable biomarker of disease activity. In a cohort study, urinary pellets from 40 patients diagnosed with systemic lupus erythematosus (SLE) were analyzed...
Includes: Supplementary data
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2013) 124 (12): 709–717.
Published: 26 February 2013
.... In the present study, we tested the hypothesis that corin may be present in human urine and that urinary corin levels may be altered in patients with kidney disease. We obtained urine and kidney tissue samples from normal individuals and CKD (chronic kidney disease) patients. Using ELISA, we detected corin...
Articles
Paul R. Kalra, Jonathan R. Clague, Andrew J. Coats, Stefan D. Anker, Philip A. Poole-Wilson, Allan D. Struthers
Journal:
Clinical Science
Clin Sci (Lond) (2010) 118 (1): 71–77.
Published: 02 October 2009
... effects adjacent to its site of production. In the human kidney, CNP is located in cells of all tubular segments and glomeruli [ 10 ]. Studies in humans with CHF have provided conflicting results on whether urine CNP is altered or not [ 11 – 13 ]. To clarify the issue of renal CNP production, we...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2003) 105 (2): 195–202.
Published: 01 August 2003
... and tRNA, and are thought to be potential indicators of the resting metabolic rate. To investigate diurnal variations of these RNA catabolites, the amounts of ѱ, m 2 2 G and t 6 A excreted were determined by HPLC of the urine from eight healthy male adults collected over 47-h periods, which were subdivided...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2003) 104 (5): 483–490.
Published: 01 May 2003
... of patients with tubular proteinuria may have downstream effects on renal tubular function. In renal Fanconi syndromes, such as Dent's disease, peptides implicated in altered tubular function or injury have recently been measured in urine by immunochemical methods. However, the limited availability...
Articles
Hiroshi ASAKAWA, Toshio NISHIKIMI, Takeshi SUZUKI, Suomi HARA, Yusuke TSUBOKOU, Hiroshi YAGI, Akihisa YABE, Noriaki TSUCHIYA, Shigeo HORINAKA, Kenji KANGAWA, Hiroaki MATSUOKA
Journal:
Clinical Science
Clin Sci (Lond) (2001) 100 (1): 117–126.
Published: 13 December 2000
...: an active, mature form of AM (AM-m) and an intermediate, inactive, glycine-extended form of AM (AM-Gly). In the present study we investigated the pathophysiological significance of the two molecular forms of AM in plasma and urine in patients with acute myocardial infarction. We serially measured venous...
Articles
Caroline DEAN, Jerry KANELLOS, Hung PHAM, Maria GOMES, Adrian OATES, Phulwinder GROVER, Rosemary RYALL
Journal:
Clinical Science
Clin Sci (Lond) (2000) 98 (4): 471–480.
Published: 22 March 2000
...), were purified further by HPLC. Their purity was confirmed by SDS/PAGE. Using Coulter counter and [ 14 C]oxalate analysis and scanning electron microscopy, ∣α∣, its H1 chain and bikunin from urine and from plasma were shown to be relatively weak inhibitors of CaOx crystallization in vitro at expected...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2000) 98 (2): 151–158.
Published: 06 January 2000
...J. P. KAVANAGH; L. JONES; P. N. RAO We have studied the kinetics of oxalate-induced turbidity in fresh human urine and artificial urine. Assays are performed in 96-well plates, which allows many oxalate concentrations to be studied, repeatedly, in a short time. The metastable limit is defined...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (1997) 92 (2): 205–213.
Published: 01 February 1997
...Phulwinder K. Grover; Rosemary L. Ryall 1. The aim of this study was to determine whether seed crystals of uric acid or monosodium urate promote the epitaxial deposition of calcium oxalate in undiluted human urine. The effects of seed crystals of uric acid, monosodium urate or calcium oxalate...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (1993) 85 (3): 303–307.
Published: 01 September 1993
...Phulwinder K. Grover; Rosemary L. Ryall; Villis R. Marshall 1. Increasing the concentration of dissolved urate promotes the crystallization of calcium oxalate from urine. The possibility was investigated that this effect may be caused by heterogeneous nucleation of calcium oxalate by particles...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (1993) 84 (4): 469–475.
Published: 01 April 1993
... 4 1 1993 © 1993 The Biochemical Society and the Medical Research Society 1993 N-acetyl-β-D-glucosaminidase alanine aminopeptidase alkaline phosphatase diabetes mellitus dipeptidyl aminopeptidase IV γ-glutamyl transpeptidase non-insulin-dependent diabetes urine Clinical...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (1992) 83 (4): 461–465.
Published: 01 October 1992
... and creatinine in consecutive portions of urine collected during 24 h in 15 healthy non-smoking subjects. 2. The total 24 h excretion of Tx-M and PGI-M did not differ between men (223 ± 31 and 132 ± 27 ng, respectively) and women (215 ± 44 and 127 ± 29 ng, respectively). Neither the excretion of Tx-M nor...
Articles
Nobuhito Hirawa, Yoshio Uehara, Atsushi Numabe, Satoru Takada, Hiroaki Matsuoka, Toshio Ikeda, Tsuneaki Sugimoto, Shigeru Yagi, Masao Ishii
Journal:
Clinical Science
Clin Sci (Lond) (1991) 81 (s25): 499–507.
Published: 01 October 1991
... vasorelaxation and natriuresis. atenolol β-adrenoceptor blocker kidney prostacyclin prostaglandin E 2 urine vascular wall © 1991 The Biochemical Society and the Medical Research Society 1991 25 4 1991 30 4 1991 Clinical Science (1991) 81,499-507 499 Stimulating effects...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (1991) 81 (3): 305–311.
Published: 01 September 1991
... similar in both groups. 3. Frusemide increased the urine volume and the excretion of Na + , K + , Mg 2+ , Cl − , aldosterone, prostaglandin E 2 and tissue kallikrein. These changes were similar in both groups, but the total tissue kallikrein excretion was significantly lower in the hypertensive patients...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (1990) 79 (2): 117–121.
Published: 01 August 1990
...-vasopressin. 2. During acute oral water loading, excretion of active kallikrein was unchanged, despite high urine flow rates and low urine osmolalities being achieved. Excretion of inactive kallikrein correlated with the urine flow rate. 3. After desamino-d-arginine-vasopressin in eight water-loaded and six...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (1990) 79 (1): 9–15.
Published: 01 July 1990
...Phulwinder K. Grover; Rosemary L. Ryall; Villis R. Marshall 1. The effect of hyperuricosuria, simulated by increasing the concentration of dissolved urate, on the crystallization of calcium oxalate in human urine was examined. 2. Twenty urine samples were studied. Ten of these, designated type...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (1990) 78 (2): 181–184.
Published: 01 February 1990
...J. Haylor; C. J. Lote 1. The influence of urine pH on the urinary excretion of prostaglandin (PG) F 2α and the PGE 2 /PGF 2α ratio has been examined in the conscious rat. 2. The basal urinary PGF 2α excretion rate of 3.9 pmol/h ( n = 23) did not vary with urine pH. In marked contrast, PGE 2...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (1988) 74 (4): 377–384.
Published: 01 April 1988
... and recoveries of methylxanthine metabolites in urine for 48 h after a 400 mg oral caffeine load. 2. In the control group, the mean (± sd ) serum caffeine clearance was 1.3 ± 0.4 ml min −1 kg −1 and a mean of 56.4 ± 16.5% of the administered caffeine was recovered from the urine over 48 h as methyluric acids...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (1987) 73 (3): 277–283.
Published: 01 September 1987
...Ulrich Förstermann; Thomas J. Feuerstein 1. The rates of secretion into the circulation of prostaglandin E, prostacyclin, and thromboxane A 2 were estimated in male alcoholics on the third day of withdrawal and in control subjects by measuring appropriate metabolites in urine. 2. Urinary levels...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (1986) 71 (4): 367–374.
Published: 01 October 1986
... RNA urine ClinicalScience( 1986) 71, 367-374 367 Ribonucleic acid turnover in man: RNA catabolites in urine as measure for the metabolism of each of the three major species of RNA GERNOT SANDER, HEINRICH TOPP, GESA HELLER-SCHOCH, Forschungsinstitut f i r Kinderernahrung, Dortmund, Federal Republic...
Articles
Gordon T. McInnes, Josue G. Flores, John R. Shelton, Ian R. Harrison, Richard M. Perkins, Joan M. Clarke
Journal:
Clinical Science
Clin Sci (Lond) (1986) 71 (1): 125–128.
Published: 01 July 1986
...Gordon T. McInnes; Josue G. Flores; John R. Shelton; Ian R. Harrison; Richard M. Perkins; Joan M. Clarke 1. Normal diet and a simple short term prescribed diet were compared with respect to mean excretion of urine electrolytes and the variability in these responses in 12 healthy male subjects...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (1985) 69 (3): 299–308.
Published: 01 September 1985
... were increased in ileostomized patients when compared with normal subjects, but were unaffected by the change to a low sodium diet. 5. An early increase in urine flow and water diuresis occurred during sodium deprivation, following a cyclical pattern with peaks each evening. There were no corresponding...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (1985) 68 (5): 601–604.
Published: 01 May 1985
...A. Barden; L. J. Beilin; R. Vandongen; I. Rouse 1. Measurement of urinary 6-ketoprostaglandin (PG) F 1α and PGE 2 excretion in 83 healthy children, aged 5-15 years, revealed that supervised 4 h urine collections under mild water diuresis provided more consistent results than overnight 12 h urine...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (1985) 68 (4): 475–477.
Published: 01 April 1985
...J. Haylor; J. M. Toner; P. R. Jackson; L. E. Ramsay; C. J. Lote 1. The relationship between urine pH, modified by the oral administration of either ammonium chloride or sodium bicarbonate, and the urinary excretion of prostaglandin E (PGE) was studied in healthy female subjects. 2. The urinary...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (1983) 64 (6): 629–635.
Published: 01 June 1983
...Sheila Bingham; J. H. Cummings 1. At the present time there is no method whereby the completeness of 24 h urine collections can be accurately assessed when clinical studies are undertaken. The suitability of 4-aminobenzoic acid (PAB) given with meals as a marker for completeness of urine...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (1983) 64 (3): 333–340.
Published: 01 March 1983
...R. A. Harkness; R. J. Simmonds; S. B. Coade 1. After decreasing muscle ATP by a 2 min period of intense exercise, we have studied purine metabolism by using high-pressure liquid chromatography. 2. A major increase in hypoxanthine concentration in plasma and urine was found with increases...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (1982) 62 (4): 421–425.
Published: 01 April 1982
...P. C. Hallson; G. A. Rose; S. Sulaiman 1. Samples of fresh human urine were treated with immobilized uricase to lower urate concentration. Urate was added to yield low, normal and high urate samples. 2. Each sample was rapidly evaporated at pH 5.3 to standard osmolality and the yield of calcium...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (1982) 62 (1): 21–26.
Published: 01 January 1982
...K. L. Lynn; A. Shenkin; R. D. Marshall 1. Tamm—Horsfall glycoprotein was determined, by radioimmunoassay, in samples of urine from normal individuals under a variety of physiological conditions 2. The amount of glycoprotein excreted in 24 h by our population (39 ± 13 mg, corrected for body surface...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (1982) 62 (1): 17–19.
Published: 01 January 1982
...P. C. Hallson; G. A. Rose; S. Sulaiman 1. A low urinary magnesium was induced in normal volunteer subjects by giving cellulose phosphate; magnesium was added in vitro to yield urine samples of normal and high magnesium concentrations 2. After rapid evaporation of these urine samples at pH 5.3...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (1981) 61 (4): 407–415.
Published: 01 October 1981
...S. Moss; D. Gordon; Mary L. Forsling; W. S. Peart; V. H. T. James; Shirley A. Roddis 1. The electrolyte and water composition of urine and ileal fluid was studied in six patients with ileostomies during dietary sodium deprivation and at the same time measurements were made of plasma renin activity...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (1981) 60 (6): 693–702.
Published: 01 June 1981
..., where daily baseline albumin excretion was 1.8–22 mg/24 h. 2. In low-to-intermediate excretors ‘sex-associated’ urinary specific proteins, supposedly present only in male rat urine, were excreted in larger quantities than albumin which constituted only 10–15% of the total urinary protein. 3. In high...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (1981) 60 (4): 411–418.
Published: 01 April 1981
...A. M. Finch; G. P. Kasidas; G. A. Rose 1. Urinary composition was studied in nine healthy adults on unrestricted diet and low-oxalate diet with and without individual oxalate-rich foods. 2. Urine oxalate was constant on the low-oxalate and constant high-oxalate diets and only fluctuated greatly...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (1979) 56 (5): 419–426.
Published: 01 May 1979
...N. M. Bass; R. E. Kirsch; S. A. Tuff; J. A. Campbell; J. S. Saunders 1. A radioimmunoassay was used to establish normal urine excretion of ligandin, a renal tubular protein, in rats, and to study the pattern of ligandin excretion after nephrotoxin administration. 2. Validation of radioimmunoassay...
Articles
Journal:
Clinical Science
Clin Sci Mol Med (1978) 54 (5): 509–516.
Published: 01 May 1978
... this dose of EHDP daily for 12 months and seven were then studied for a further 12 months under placebo. During treatment with EHDP, inhibitory activity in urine towards precipitation of calcium phosphate was restored from low values to greatly above normal. This could be accounted for by the inhibitory...
Articles
Journal:
Clinical Science
Clin Sci Mol Med (1978) 54 (4): 349–353.
Published: 01 April 1978
...N. Nijs-De Wolf; N. De Nutte; H. Brauman; J. Corvilain 1. The parathyroid hormone-like biological activity of concentrated urine was measured by the increase of plasma calcium concentration after intravenous injection of the sample into chickens. 2. Urine was tested in hypoparathyroid patients...
Articles
Journal:
Clinical Science
Clin Sci Mol Med (1977) 53 (4): 373–377.
Published: 01 October 1977
... in serum, urine and bile. 2. The chromatography data indicated an excretion of 25-hydroxycholecalciferol both in bile and urine and, in urine, also of 1,25-dihydroxycholecalciferol. In bile, fractions of labelled substances were also obtained which, according to their elution positions, might represent...
Articles
Journal:
Clinical Science
Clin Sci Mol Med (1974) 47 (6): 589–598.
Published: 01 December 1974
... ingested, urinary sodium excretion was reduced by approximately 40% but there was no change in urine flow. The decrease in sodium excretion was associated with a rise in hydrogen ion excretion. 3. These results suggest that sodium ion is retained in exchange for hydrogen ion in the distal segment...
Articles
Journal:
Clinical Science
Clin Sci Mol Med (1974) 46 (3): 357–367.
Published: 01 March 1974
... of the urine with respect to calcium oxalate. The implication of these findings with respect to the cause and treatment of calcium oxalate stones is discussed. 10 9 1973 © 1974 The Biochemical Society and the Medical Research Society 1974 urinary calculi urine oxalates calcium magnesium...
Articles
Journal:
Clinical Science
Clin Sci Mol Med (1973) 45 (5): 607–623.
Published: 01 November 1973
... applicability and which involves the measurement of free steroid by direct extraction into toluene-based liquid scintillator. 3. A new method, of validated specificity, is described for the measurement of the acid-labile metabolite of aldosterone in urine which avoids the necessity for preliminary...
Articles
Journal:
Clinical Science
Clin Sci Mol Med (1973) 45 (1): 115–127.
Published: 01 July 1973
... patients by failing to decline in late pregnancy. 26 6 1972 © 1973 The Biochemical Society and the Medical Research Society 1973 pregnancy toxaemia renin angiotensin electrolytes sodium potassium creatinine urine plasma kidney CIinical Science and Molecular Medicine (1973) 45...
