...Inês Vasconcelos; Rui Adão; Miriam T. Rademaker; Adelino F. Leite-Moreira; Ana Patrícia Fontes-Sousa; Carmen Brás-Silva The urocortins (Ucns) belong to the corticotropin-releasing factor (CRF) family of peptides and have multiple effects within the central nervous and the cardiovascular systems...

... evaluating the two principal approaches to renin inhibition, namely direct renin inhibition with aliskiren and inhibition of the (pro)renin receptor. Moreover, the possibilities of renin inhibition and nephroprotection by interventions primarily aiming at non-RAAS targets, such as vitamin D, urocortins...

...Christopher J. Charles; Miriam T. Rademaker; A. Mark Richards In addition to haemodynamic actions, Ucn1 (urocortin 1) has been reported to affect a number of hormonal systems; however, it remains unclear whether Ucn1 modulates circulating hormones under physiological conditions. Accordingly...

...Leong L. NG; Ian W. LOKE; Russell J. O'BRIEN; Iain B. SQUIRE; Joan E. DAVIES Urocortin (UCN), a member of the corticotrophin-releasing factor family, is expressed in heart, brain and gut. UCN has potent cardiostimulatory, cardioprotective, vasodilator and diuretic/natriuretic effects, and cardiac...

...Miwa UZUKI; Hironobu SASANO; Yasunari MURAMATSU; Kazuhito TOTSUNE; Kazuhiro TAKAHASHI; Yutaka OKI; Kazumi IINO; Takashi SAWAI Urocortin is a newly identified member of the corticotropin-releasing factor (CRF) neuropeptide family, and is known to be involved in the modulation of the inflammatory...