... dysfunction under pathological conditions. basilar artery cerebral artery high fat O- GlcNAc vascular contraction O -GlcNAc levels are regulated in part by the metabolism of glucose via the HBP, and the metabolic abnormalities associated with insulin resistance and diabetes...

.... This practice was justified by the belief that PVAT, as a connective tissue, provides only mechanical support to vessels, but does not play any role in vascular contraction. This view is still illustrated in almost any diagram of vascular structure/function with endothelium, smooth muscle and adventitia...