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Keywords: vascular dysfunction
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Clin Sci (Lond) (2020) 134 (7): 827–851.
Published: 09 April 2020
... alteration associated with vascular remodeling and atherosclerosis [ 78–81 ]. Interestingly, both the progression of adipose tissue inflammation and vascular dysfunction downstream of PAR signaling appear to occur via common targets including HIF1-α, NF-κB, ROCK, and cyclooxygenase-2 [ 44 , 81–84...
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Clin Sci (Lond) (2019) 133 (7): 885–904.
Published: 12 April 2019
... vessel tone are altered by oxidative damage of vascular endothelial cells, thus promoting vascular dysfunction, a key driver of CVD. In this review, the detrimental role of oxidative stress in COPD and comorbid CVD are discussed and we propose that targeting oxidant-dependent mechanisms represents...
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Clin Sci (Lond) (2015) 129 (2): 159–167.
Published: 24 April 2015
.... ageing cutaneous blood flow folate supplementation methyltetrahydrofolate vascular dysfunction • This study was conducted to determine if folic acid may be a viable intervention strategy for improved microvascular vasodilator function in older adults. • Our results suggest that folic...
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Clin Sci (Lond) (2014) 127 (4): 265–275.
Published: 29 April 2014
... improvement. The aim of the present study was to evaluate the effects of metformin treatment on vascular dysfunction in ovariectomized rats. At 8 weeks of age, female Wistar rats were subjected to ovariectomy or a sham surgery. After 21 days, the animals were divided into three groups: SHAM (sham-operated...
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Clin Sci (Lond) (2014) 127 (2): 111–122.
Published: 28 March 2014
... effects on the vasculature, augmenting vascular responses to contractile stimuli. As NO/cGMP signalling plays a role in vascular dysfunction associated with obesity and the metabolic syndrome, we hypothesized that chemerin induces vascular dysfunction by decreasing NO/cGMP signalling. Aortic rings from...
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Clin Sci (Lond) (2013) 124 (5): 333–342.
Published: 16 November 2012
...Kathleen M. Lukaszewicz; John R. Falck; Vijaya L. Manthati; Julian H. Lombard The present study tested the hypothesis that the Dahl SS (salt-sensitive) rat has vascular dysfunction due, in part, to the up-regulation of the CYP4A/20-HETE (cytochrome P450 ω-hydroxylase 4A)/20-hydroxyeicosatetraenoic...
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Clin Sci (Lond) (2010) 118 (4): 291–301.
Published: 16 November 2009
...Ahmed A. Elmarakby; John D. Imig Obesity and hypertension are the two major risk factors that contribute to the progression of end-stage renal disease. To examine whether hypertension further exacerbates oxidative stress and vascular dysfunction and inflammation in obese rats, four groups of male...
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Clin Sci (Lond) (2008) 115 (9): 295–300.
Published: 01 October 2008
...Faisel Khan; Dean Patterson; Jill J.F. Belch; Kumiko Hirata; Chim C. Lang Vascular dysfunction in the coronary and peripheral circulations is an early prognostic marker of future cardiovascular events. Measurements of coronary and peripheral vascular function in resistance vessels can be made...
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