...) exposure, worsens vascular function and if so, whether the antioxidant ebselen alleviates this vascular dysfunction. Male BALB/c mice were exposed to either room air or CS for 8 weeks followed by inoculation with IAV (Mem71, 1 × 10 4.5 pfu). Mice were treated with ebselen (10 mg/kg) or vehicle (5% w/v CM...

... and redox stress but only partially restore endothelial function in mesenteric vessels. We investigated whether sympatho-adrenal overactivation evokes coronary vascular dysfunction when a high salt intake is combined with insulin resistance in male Goto–Kakizaki (GK) and Wistar rats treated with two...

...Tamara Sáez; Floor Spaans; Raven Kirschenman; Tatsuya Sawamura; Sandra T. Davidge The lectin-like oxidized low-density-lipoprotein (oxLDL) receptor-1 (LOX-1) has been shown to induce angiotensin II (AngII) type 1 receptor (AT 1 ) activation, contributing to vascular dysfunction. Preeclampsia...

... 2020 © 2020 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2020 diabetes Epicardial Adipose Heart failure obesity Perivascular Adipose Vascular dysfunction Metabolic disorders including Type 2 diabetes (T2DM) and obesity are steadily...

... vessel tone are altered by oxidative damage of vascular endothelial cells, thus promoting vascular dysfunction, a key driver of CVD. In this review, the detrimental role of oxidative stress in COPD and comorbid CVD are discussed and we propose that targeting oxidant-dependent mechanisms represents...

... oligomers (SPOs) that contribute to the inflammation and vascular dysfunction observed in sepsis via the activation of one or more PRRs including FPR. Our laboratory has shown increased levels of SPOs in the heart and intrarenal arteries of septic mice. We have also observed that exposure of resistance...

... flow folate supplementation methyltetrahydrofolate vascular dysfunction • This study was conducted to determine if folic acid may be a viable intervention strategy for improved microvascular vasodilator function in older adults. • Our results suggest that folic acid and its metabolite...

... improvement. The aim of the present study was to evaluate the effects of metformin treatment on vascular dysfunction in ovariectomized rats. At 8 weeks of age, female Wistar rats were subjected to ovariectomy or a sham surgery. After 21 days, the animals were divided into three groups: SHAM (sham-operated...

... effects on the vasculature, augmenting vascular responses to contractile stimuli. As NO/cGMP signalling plays a role in vascular dysfunction associated with obesity and the metabolic syndrome, we hypothesized that chemerin induces vascular dysfunction by decreasing NO/cGMP signalling. Aortic rings from...

...Kathleen M. Lukaszewicz; John R. Falck; Vijaya L. Manthati; Julian H. Lombard The present study tested the hypothesis that the Dahl SS (salt-sensitive) rat has vascular dysfunction due, in part, to the up-regulation of the CYP4A/20-HETE (cytochrome P450 ω-hydroxylase 4A)/20-hydroxyeicosatetraenoic...

... response and to produce systemic maternal inflammation and vascular dysfunction that lead to hypertension and IUGR (intra-uterine growth restriction). The proposed hypothesis implicates mtDNA in the development of PE via activation of the immune system and may have important preventative and therapeutic...

...Ahmed A. Elmarakby; John D. Imig Obesity and hypertension are the two major risk factors that contribute to the progression of end-stage renal disease. To examine whether hypertension further exacerbates oxidative stress and vascular dysfunction and inflammation in obese rats, four groups of male...

...Faisel Khan; Dean Patterson; Jill J.F. Belch; Kumiko Hirata; Chim C. Lang Vascular dysfunction in the coronary and peripheral circulations is an early prognostic marker of future cardiovascular events. Measurements of coronary and peripheral vascular function in resistance vessels can be made...

... studies and experimental models have revealed underlying the adult cardiovascular phenotype dictated by the perinatal experience, as well as the probable key causal or triggering elements. Programmed elevated blood pressure in the adult human or animal is characterized by vascular dysfunction...

... to moderate hypertriglyceridaemia. Correspondence: Dr E. K. Naderali (e-mail naderali@liverpool.ac.uk ). 13 3 2001 23 5 2001 9 7 2001 The Biochemical Society and the Medical Research Society © 2001 2001 diet-induced obesity insulin resistance vascular dysfunction...