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Keywords: vascular endothelial growth factor
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Clin Sci (Lond) (2022) 136 (9): 675–694.
Published: 10 May 2022
... Visser; A.H. Jan Danser; Jorie Versmissen Vascular endothelial growth factor antagonism with angiogenesis inhibitors in cancer patients induces a ‘preeclampsia-like’ syndrome including hypertension, proteinuria and elevated endothelin (ET)-1. Cyclo-oxygenase (COX) inhibition with aspirin is known...
Includes: Supplementary data
Clin Sci (Lond) (2021) 135 (5): 683–686.
Published: 02 March 2021
... ( cferrari@wakehealth.edu ) 28 01 2021 12 02 2021 16 02 2021 © 2021 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2021 adipocytes angiotensin converting enzyme 2 heart failure vascular endothelial growth factor Obesity...
Clin Sci (Lond) (2021) 135 (1): 71–100.
Published: 06 January 2021
.... However, these drugs are associated with cardiovascular toxicities which can impact optimal cancer treatment in the short-term and may lead to increased morbidity and mortality in the longer term. Vascular endothelial growth factor inhibitors (VEGFIs) are associated with hypertension, left ventricular...
Clin Sci (Lond) (2020) 134 (18): 2503–2520.
Published: 29 September 2020
... antibodies that target angiogenesis by inhibiting vascular endothelial growth factor (VEGF) signaling pathways. Despite their anti-angiogenic and anti-cancer benefits, the use of VEGF inhibitors (VEGFi) and other tyrosine kinase inhibitors (TKIs) has been hampered by potent vascular toxicities especially...
Clin Sci (Lond) (2019) 133 (12): 1271–1280.
Published: 17 June 2019
... of the Biochemical Society 2019 angiogenesis hypoxia Mycobacterium tuberculosis vascular endothelial growth factor The conserved vascular pathologies of TB granulomas and tumours have also been well described, and open the door to ‘Robin Hood’ well-known vascular-targeting strategies from the cancer...
Clin Sci (Lond) (2017) 131 (23): 2763–2775.
Published: 23 November 2017
...Vincent Pang; David O. Bates; Lopa Leach The human placenta nourishes and protects the developing foetus whilst influencing maternal physiology for fetal advantage. It expresses several members of the vascular endothelial growth factor (VEGF) family including the pro-angiogenic/pro-permeability...
Clin Sci (Lond) (2017) 131 (12): 1225–1243.
Published: 31 May 2017
... of both the inner and outer retinal barriers of the retinal vasculature and retinal pigmented epithelial (RPE)–choroid respectively. Vascular endothelial growth factor (VEGF-A), a key regulator of angiogenesis and permeability, is the target of most pharmacological interventions of DR. VEGF-A can...
Clin Sci (Lond) (2011) 121 (12): 555–564.
Published: 22 August 2011
... compared with S group, after ischaemic injury. In addition, immunostaining and Western blot analyses revealed that impaired angiogenic response in V mice occurred in association with reduced VEGF (vascular endothelial growth factor) production and decreased eNOS (endothelial nitric oxide synthase) and Akt...
Clin Sci (Lond) (2003) 104 (4): 397–404.
Published: 14 March 2003
... of angiogenesis, that is vascular endothelial growth factor (VEGF) and its soluble receptor sFlt-1. We studied 234 patients (145 males; mean age 68.6±10 years) with proven PAD (ankle brachial pressure index <0.8) and compared them with 50 healthy controls. Levels of VEGF ( P = 0.001) and TF ( P = 0.043) were...
Clin Sci (Lond) (2002) 103 (s2002): 424S–429S.
Published: 01 September 2002
... to determine the effect of diabetes mellitus on endothelin (ET)-1, ET-3, vascular endothelial growth factor (VEGF) and interleukin-8 (IL-8)-mediated angiogenesis. In an initial group of experiments, streptozotocin-induced diabetes resulted in impairment of ET-1-mediated angiogenesis from 69% to 32...
Clin Sci (Lond) (2002) 103 (s2002): 450S–454S.
Published: 01 September 2002
...Masumi AKIMOTO; Hiroshi HASHIMOTO; Atsushi MAEDA; Mutsuo SHIGEMOTO; Katsuko YAMASHITA Endothelins (ETs) participate directly and indirectly in angiogenesis via ET receptors. During early fetal angiogenesis, vascular endothelial growth factor (VEGF) and its receptors kinase insert domain-containing...
Clin Sci (Lond) (2001) 101 (3): 305–311.
Published: 15 August 2001
... claudication. However, the mechanisms by which exercise tolerance is improved remain unclear. Vascular endothelial growth factor (VEGF) is a potent endothelial mitogen that results in angiogenesis when overexpressed in human subjects. To assess the potential role of VEGF in the improvement in exercise...
Clin Sci (Lond) (2001) 100 (5): 567–575.
Published: 10 April 2001
...Funmi M. BELGORE; Andrew D. BLANN; Gregory Y. LIP Vascular endothelial growth factor (VEGF) mediates endothelial cell mitogenesis and enhances vascular permeability. VEGF interacts with the endothelium via two membrane-spanning receptors, fms-like tyrosine kinase (Flt)-1 and kinase domain receptor...
Clin Sci (Lond) (2000) 99 (2): 159–160.
Published: 17 July 2000
...Giovambattista DESIDERI; Claudio FERRI Correspondence : Dr G Desideri (e-mail gbdesi@freemail.it ). 13 12 1999 The Biochemical Society and the Medical Research Society © 2000 2000 chronic hepatitis cirrhosis vascular endothelial growth factor 159Clinical Science (2000...
Clin Sci (Lond) (1998) 94 (4): 395–404.
Published: 01 April 1998
...Nicholas J. A. Webb; Martyn J. Bottomley; Carolyn J. Watson; Paul E. C. Brenchley 1. Dysregulated vascular endothelial growth factor (VEGF) expression has been reported in several pathological states based upon evidence of elevated serum VEGF levels. Using two immunoassays for VEGF, this study...
Clin Sci (Lond) (1997) 92 (5): 453–454.
Published: 01 May 1997
...Yoshinori Seko; Yasushi Imai; Shin Suzuki; Shuichi Kamijukkoku; Kazuya Hayasaki; Yasuinari Sakomura; Kazuyuki Tobe; Takashi Kadowaki; Hiromitsu Maekawa; Naoyuki Takahashi; Yoshio Yazaki 1. Vascular endothelial growth factor, a potent angiogenic mitogen, is known to be induced in response...