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Keywords: vascular endothelial growth factor
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Clin Sci (Lond) (2021) 135 (1): 71–100.
Published: 06 January 2021
.... However, these drugs are associated with cardiovascular toxicities which can impact optimal cancer treatment in the short-term and may lead to increased morbidity and mortality in the longer term. Vascular endothelial growth factor inhibitors (VEGFIs) are associated with hypertension, left ventricular...
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Clin Sci (Lond) (2020) 134 (18): 2503–2520.
Published: 29 September 2020
... antibodies that target angiogenesis by inhibiting vascular endothelial growth factor (VEGF) signaling pathways. Despite their anti-angiogenic and anti-cancer benefits, the use of VEGF inhibitors (VEGFi) and other tyrosine kinase inhibitors (TKIs) has been hampered by potent vascular toxicities especially...
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Clin Sci (Lond) (2019) 133 (12): 1271–1280.
Published: 17 June 2019
... of a leaky and haemostatic vasculature through the production of vascular endothelial growth factor (VEGF) and angiopoietin (ANG)-2. The lack of sufficient perfusion prevents the penetration of drugs into each lesion resulting in phenotypic insensitivity. Activation of haemostasis is a common strategy...
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Clin Sci (Lond) (2011) 121 (12): 555–564.
Published: 22 August 2011
... compared with S group, after ischaemic injury. In addition, immunostaining and Western blot analyses revealed that impaired angiogenic response in V mice occurred in association with reduced VEGF (vascular endothelial growth factor) production and decreased eNOS (endothelial nitric oxide synthase) and Akt...
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Clin Sci (Lond) (2002) 103 (s2002): 450S–454S.
Published: 01 September 2002
...Masumi AKIMOTO; Hiroshi HASHIMOTO; Atsushi MAEDA; Mutsuo SHIGEMOTO; Katsuko YAMASHITA Endothelins (ETs) participate directly and indirectly in angiogenesis via ET receptors. During early fetal angiogenesis, vascular endothelial growth factor (VEGF) and its receptors kinase insert domain-containing...
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