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1-15 of 15
Keywords: vascular function
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Articles
Khatera Saii, Judit Prat-Duran, Ulf Simonsen, Anders Riegels Knudsen, Jonas Amstrup Funder, Niels Henrik Buus, Estéfano Pinilla
Journal:
Clinical Science
Clin Sci (Lond) (2025) 139 (1): 1–14.
Published: 15 January 2025
... Vascular function Cardiovascular risk factors, including diabetes, hypertension, dyslipidemia, and smoking, accelerate the aging process and contribute to age-associated alterations such as endothelial dysfunction and stiffness in the vasculature [ 1 ]. These alterations can eventually lead...
Includes: Supplementary data
Articles
Renin–angiotensin system overactivation in perivascular adipose tissue contributes to vascular dysfunction in heart failure
Available to PurchaseMilene Tavares Fontes, Suliana Mesquita Paula, Caroline Antunes Lino, Nathalia Senger, Gisele Kruger Couto, Maria Luiza de Morais Barreto-Chaves, José Geraldo Mill, Luciana Venturini Rossoni
Journal:
Clinical Science
Clin Sci (Lond) (2020) 134 (23): 3195–3211.
Published: 09 December 2020
... Society 2020 heart failure perivascular adipose tissue renin-angiotensin system vascular function Twelve weeks after the MI or SO surgery, the left ventricle hemodynamic parameters were measured in anesthetized animals (urethane, 1.2 g/kg, i.p.; Sigma-Aldrich, St. Louis, MO, U.S.A...
Includes: Supplementary data
Articles
Alterations in vascular function by syncytiotrophoblast extracellular vesicles via lectin-like oxidized low-density lipoprotein receptor-1 in mouse uterine arteries
Available to PurchaseFloor Spaans, Anita Quon, Stewart R. Rowe, Jude S. Morton, Raven Kirschenman, Tatsuya Sawamura, Dionne S. Tannetta, Ian L. Sargent, Sandra T. Davidge
Journal:
Clinical Science
Clin Sci (Lond) (2018) 132 (21): 2369–2381.
Published: 13 November 2018
... to interact with the angiotensin II type 1 receptor (AT-1). We hypothesized that, in pregnant mice, STBEVs would impair vascular function via LOX-1 and would specifically affect angiotensin II responses. Uterine arteries from pregnant control (C57BL/6) and LOX-1 knockout (LOX-1KO) mice were isolated...
Articles
Vascular dysfunction in the stroke-prone spontaneously hypertensive rat is dependent on constrictor prostanoid activity and Y chromosome lineage
Available to PurchaseShanzana I. Khan, Karen L. Andrews, Ann-Maree Jefferis, Garry L. Jennings, Amanda K. Sampson, Jaye P.F. Chin-Dusting
Journal:
Clinical Science
Clin Sci (Lond) (2018) 132 (1): 131–143.
Published: 16 January 2018
... (IP) receptor, while inhibition of the thromboxane (TP) receptor significantly ameliorated vascular dysfunction in the SHRSP, suggesting this is the downstream target responsible for constrictor prostanoid activity. Importantly, Y chromosome lineage was shown to modulate vascular function in the SHRSP...
Includes: Supplementary data
Articles
Oxidative and inflammatory signals in obesity-associated vascular abnormalities
Available to Purchase
Journal:
Clinical Science
Clin Sci (Lond) (2017) 131 (14): 1689–1700.
Published: 30 June 2017
... of the surrounding perivascular adipose tissue (PVAT) on the regulation of vascular function and arterial stiffening in obesity. In particular, we focus on the highly plastic nature of the vasculature in response to altered oxidant and inflammatory signaling and highlight how weight management can be an effective...
Articles
Does high-density lipoprotein protect vascular function in healthy pregnancy?
Available to PurchaseWan N. Wan Sulaiman, Muriel J. Caslake, Christian Delles, Helen Karlsson, Monique T. Mulder, Delyth Graham, Dilys J. Freeman
Journal:
Clinical Science
Clin Sci (Lond) (2016) 130 (7): 491–497.
Published: 17 February 2016
... with poor vascular function. However, maternal vascular function is enhanced in pregnancy. It is not understood how this is achieved in the face of the adverse metabolic and inflammatory environment. Research into cardiovascular disease demonstrates that plasma HDL (high-density lipoprotein), by merit...
Articles
Vascular injury in diabetic db/db mice is ameliorated by atorvastatin: role of Rac1/2-sensitive Nox-dependent pathways
Available to PurchaseThiago Bruder-Nascimento, Glaucia E. Callera, Augusto C. Montezano, Ying He, Tayze T. Antunes, Aurelie Nguyen Dinh Cat, Rita C. Tostes, Rhian M. Touyz
Journal:
Clinical Science
Clin Sci (Lond) (2015) 128 (7): 411–423.
Published: 09 December 2014
... Biochemical Society 2015 inflammation NADPH oxidase (Nox) oxidative stress statin Type 2 diabetes vascular function • Statins, cholesterol-lowering drugs, improve vascular function in diabetes, but exact mechanisms are elusive. • We demonstrated that, in a mouse model of Type 2...
Includes: Supplementary data
Articles
Role of the CYP4A/20-HETE pathway in vascular dysfunction of the Dahl salt-sensitive rat
Available to Purchase
Journal:
Clinical Science
Clin Sci (Lond) (2013) 124 (12): 695–700.
Published: 26 February 2013
...-5 BN rat, having chromosome 5 from the salt-resistant Brown Norway rat (carrying all CYP4A genes) introgressed on to the SS genetic background. Our laboratory has demonstrated restoration of normal vascular function in the SS rat with inhibition of the CYP4A/20-HETE pathway, suggesting a direct role...
Articles
Pre-eclampsia and offspring cardiovascular health: mechanistic insights from experimental studies
Open AccessEsther F. Davis, Laura Newton, Adam J. Lewandowski, Merzaka Lazdam, Brenda A. Kelly, Theodosios Kyriakou, Paul Leeson
Journal:
Clinical Science
Clin Sci (Lond) (2012) 123 (2): 53–72.
Published: 23 March 2012
... review and analysis highlights the pivotal role of long-term changes in vascular function and identifies areas of growing interest, specifically, response to hypoxia, immune modification, epigenetics and the anti-angiogenic in utero milieu. Correspondence: Dr Paul Leeson (email paul.leeson...
Articles
Effect of angiotensin receptor blockade on insulin sensitivity and endothelial function in abdominally obese hypertensive patients with impaired fasting glucose
Available to PurchaseTodd S. Perlstein, Robert R. Henry, Kieren J. Mather, Michael R. Rickels, Nicola I. Abate, Scott M. Grundy, Yabing Mai, Jeanine B. Albu, Jennifer B. Marks, James L. Pool, Mark A. Creager
Journal:
Clinical Science
Clin Sci (Lond) (2012) 122 (4): 193–202.
Published: 24 October 2011
..., IN, U.S.A., two at the Baylor Clinic, Houston, TX, U.S.A., and four at the University of Pennsylvania School of Medicine, Philadelphia, PA, U.S.A. angiotensin II clinical trial hypertension insulin signalling obesity vascular function Epidemic obesity threatens to reverse progress made...
Articles
Glycyrrhetinic acid attenuates vascular smooth muscle vasodilatory function in healthy humans
Available to Purchase
Journal:
Clinical Science
Clin Sci (Lond) (2010) 119 (10): 437–442.
Published: 05 August 2010
... of 11β-HSD (11-β hydroxysteroid dehydrogenase), namely 11β-HSD2 and 11β-HSD1 (type 2 and type 1 11β-HSD respectively). We hypothesized that inhibition of 11β-HSD would attenuate vascular function in healthy humans. A total of 15 healthy subjects were treated with the selective 11β-HSD inhibitor GA...
Articles
Transient receptor potential channels and vascular function
Available to Purchase
Journal:
Clinical Science
Clin Sci (Lond) (2010) 119 (1): 19–36.
Published: 07 April 2010
... to vasomotor control mechanisms in most vascular beds. Vascular TRP channels are activated by various stimuli, such as mechanical perturbation, receptor activation and dietary molecules. Some of the specific roles of these channels in normal and impaired vascular function have emerged in recent years...
Articles
Coronary flow responses to exercise training: further evidence of the benefit of an underutilized therapeutic modality
Available to Purchase
Journal:
Clinical Science
Clin Sci (Lond) (2005) 109 (3): 265–266.
Published: 24 August 2005
... improvements of vascular function and, in this issue of Clinical Science , Hägg and co-authors propose a coronary artery effect. The use of a Doppler technique for non-invasive assessment of coronary flow reserve in a small animal model is an exciting aspect of this study. If feasible in the hands of other...
Articles
The role of insulin and the adipocytokines in regulation of vascular endothelial function
Available to Purchase
Journal:
Clinical Science
Clin Sci (Lond) (2004) 107 (6): 519–532.
Published: 24 November 2004
... [email protected] ). 1 7 2004 19 8 2004 24 8 2004 24 8 2004 The Biochemical Society 2004 adipocytokine diabetes endothelium insulin obesity vascular function Endothelium-derived NO is anti-atherogenic and anti-thrombotic by virtue of its ability...
Articles
Changes in pulmonary vascular function after acute methionine loading in normal men
Available to PurchaseConor O'DOCHARTAIGH, Hean ONG, Sharon LOVELL, Ronan DONNELLY, Colm HANRATTY, Marshall RILEY, Michael FRENNEAUX, Ian YOUNG, Paul NICHOLLS
Journal:
Clinical Science
Clin Sci (Lond) (2004) 106 (4): 413–419.
Published: 01 April 2004
...-mail [email protected] ). 21 11 2003 6 1 2004 6 1 2004 © 2004 The Biochemical Society 2004 homocysteine methionine loading nitric oxide pulmonary circulation vascular function Clinical Science (2004) 106, 413 419 (Printed in Great Britain) 413 Changes...