... phenotype and neointima formation in an AKT-dependent manner in response to vascular injury. • The present study provides new function of mindin in regulation of VSMC phenotype and neointima formation and implies that up-regulation of mindin might serve as an effective therapy for neointima formation...

...Drazenka Pongrac Barlovic; Aino Soro-Paavonen; Karin A. M. Jandeleit-Dahm Diabetes is characterized by accelerated atherosclerosis with widely distributed vascular lesions. An important mechanism by which hyperglycaemia contributes to vascular injury is through the extensive intracellular...

... hypothesize that endogenous resistin derived from VSMCs may contribute to neointimal formation after vascular injury. VSMCs from thoracic aorta of adult Wistar rats were cultured. The carotid artery from adult Wistar rats was injured by balloon catheter. Resistin significantly increased migration...

... Biochemical Society 2010 apoptosis carotid artery DNA repair oxidative stress proliferation restenosis vascular injury The present strategies for severe atherosclerosis in arteries rely on angioplasty procedures, directional coronary atherectomy and bypass surgery. In reference...

... the structure and function of the uninjured artery, which may have significant implications for the comparison of injured and contralateral uninjured arteries, as is often done. In addition, it is well known that vascular injury triggers the release into the plasma of a number of molecular mediators, including...

... differentiation, as well as coagulation/fibrinolysis, should increase their future role in the prevention of restenosis. The purpose of this review is to summarize the diverse effects of retinoids on pathobiological and biological processes activated at sites of vascular injury with particular emphasis on intimal...