... kidney disease (CKD), hyperphosphatemia is a key factor promoting medial vascular calcification, a common complication associated with cardiovascular events and high mortality. Vascular calcification involves osteo-/chondrogenic transdifferentiation of vascular smooth muscle cells (VSMCs...

... exclusively in vascular smooth muscle cells (VSMCs), where it is critically involved in vascular development and differentiation. Under pathological conditions, Notch3 regulates VSMC switching between the contractile and synthetic phenotypes. Abnormal Notch3 signalling plays an important role in vascular...

... to a higher mass of vascular smooth muscle cells (VSMCs) and collagen. Vascular lipid deposits and calcification areas did not differ between the two groups. The aortic tissue level of interleukin-6 (IL-6) mRNA was 5-fold higher in the mice fed chocolate liquor than in the control mice. Chocolate-fed mice...

... understood. To investigate the postnatal role of VSMCs (vascular smooth muscle cells) EGFR in vivo and ex vivo , we generated a mouse model with cell-specific and inducible deletion of VSMC EGFR and studied the effect on basal blood pressure, acute pressure response to, among others, Ang II in vivo as well...

...Chen Yan VSMCs (vascular smooth muscle cells) play critical roles in arterial remodelling with aging, hypertension and atherosclerosis. VSMCs exist in diverse phenotypes and exhibit phenotypic plasticity, e.g. changing from a quiescent/contractile phenotype to an active myofibroblast-like, often...

...Giovanna CASTOLDI; Serena REDAELLI; Willy M. M. van de GREEF; Cira R. T. di GIOIA; Giuseppe BUSCA; Giovanni SPERTI; Andrea STELLA Ang II (angiotensin II) has multiple effects on vascular smooth muscle cells through the modulation of different classes of genes. Using the mRNA differential-display...

... atherosclerosis endothelial cells endothelin-1 oxidative stress vascular smooth muscle cells 176S Clinical Science (2002) 103 (Suppl. 48), 176S 178S (Printed in Great Britain) Endothelin-1 mRNA and protein in vascular wall cells is increased by reactive oxygen species Jan KAEHLER*, Bjoern SILL*, Ralf...

... on cellular magnesium or sodium content and exchange in vascular smooth muscle cells. 2. Therefore in aortic smooth muscle cells from 10 spontaneously hypertensive rats (SHR) of the Münster strain and 10 normotensive Wistar–Kyoto rats (WKY) aged 3 and 8–10 months, the intracellular magnesium and sodium...

...J. E. Davies; L. L. Ng; M. Ameen; P. D. Syme; J. K. Aronson 1. Intracellular pH and Na + /H + antiport activity were determined by a fluorimetric method in cultured skeletal muscle cells (myoblasts) and aortic vascular smooth muscle cells from spontaneously hypertensive and normotensive Wistar...

...Kazushi Tsuda; Seiko Tsuda; Yohsuke Minatogawa; Hideo Iwahashi; Ryo Kido; Yoshiaki Masuyama 1. Membrane fluidity of erythrocytes and cultured vascular smooth muscle cells was studied in spontaneously hypertensive rats (SHR; Okamoto and Aoki strains) by means of an electron spin resonance (e.s.r...