...-term effects on the vasculature and development of CKD are unknown. We studied whether miR-486-5p would prevent the AKI to CKD transition in rat, and affect vascular function. Methods: Adult male rats were subjected to bilateral kidney IR followed by i.v. injection of liposomal-packaged miR-486-5p (0.5...

... Vasculature The first epidemiological studies by Barker and Osmond [ 3 , 4 , 5 ] laid the foundations for the fetal origins of disease, which established links between undernutrition during fetal life (and to a lesser extent in infancy and early childhood) and patterns of chronic disease in later life...

... homeostasis hypertension nephrology renin-angiotensin system vasculature Renin-expressing cells are fundamental for the maintenance of extracellular fluid volume, and blood pressure homeostasis. Through evolution, these cells have acquired additional roles in kidney vascular development...

.... Here we consider the potential pathogenic role of tissue hypoxia in lesion development, arising partly from the vascular anatomy of the affected white matter. Specifically, these regions are supplied by a sparse vasculature fed by long, narrow end arteries/arterioles that are vulnerable to oxygen...

... of ET-1 in the vasculature during hypertension are highlighted. The present review begins with a focus on calcium signalling, regulation of calcium influx and mobilization of calcium from intracellular calcium stores. We then explore how calcium influx and mobilization are activated by ET-1 and how...

... that may play a pivotal role in driving the atherosclerotic process in conduit vessels. Furthermore, the vast surface area of the endothelium compared with conduit vessels means that the vascular effects of endothelial dysfunction or activation will be most apparent in this section of the vasculature...

... existing cardiac myocytes. This process is intimately linked to the development of coronary vasculature from progenitors originating in the endothelium, the proepicardial organ and neural crest. In this review, we systematically evaluate approx. 90 mouse mutations that impair heart muscle growth during...

... 2003 The Biochemical Society 2003 aging circulatory physiology endothelial function heart failure inflammation thrombosis vasculature Clinical Science (2003) 105, 699 707 (Printed in Great Britain) 699 Cutaneous vascular reactivity is reduced in aging and in heart failure: association...

.... Correspondence : Dr A. J. Mackay (e-mail [email protected] ). 19 9 2000 14 12 2000 26 1 2001 The Biochemical Society and the Medical Research Society © 2001 2001 vasculature pathophysiology ultrasound atherosclerosis hypertension radial artery hypertrophy...

... blocker (pentolinium) in conscious spontaneously hypertensive and Wistar Kyoto rats aged 20–28 weeks. To estimate the ‘amplifier property’ of hypertrophied vasculature in spontaneously hypertensive rats, which is known to modulate pressor responses, the lower blood pressure plateau after serial injections...

...Nicholas P. Curzen; Mark J. D. Griffiths; Timothy W. Evans © 1994 The Biochemical Society and the Medical Research Society 1994 endothelin endothelium nitric oxide sepsis vasculature Clinical Science (1994) 86, 359-374 (Printed in Great Britain) Editorial Review 359 Role...

... Research Society 1992 α-adrenoceptors catecholamine sensitivity diabetic autonomic neuropathy hand vein compliance technique noradrenaline phenylephrine sympathetic nervous system vasculature Clinical Science (1992) 82, 163-168 (Printed in Great Britain) I63 Responsiveness of superficial...