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Keywords: vasoconstriction
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Articles

Enhanced vasoconstriction in sickle cell disease is dependent on ET A receptor activation

In Collection
Endothelin XVIII Conference Collection
John Miller Allan, Brandon M. Fox, Malgorzata Kasztan, Gillian C. Kelly, Patrick A. Molina, McKenzi A. King, Jackson Colson, Leigh Wells, Latanya Bowman, Marsha Blackburn, Abdullah Kutlar, Ryan A. Harris, David M. Pollock, Jennifer S. Pollock
Journal: Clinical Science
Clin Sci (Lond) (2024) 138 (23): 1505–1520.
https://doi.org/10.1042/CS20240625
Published: 26 November 2024
... of stress-induced vasoconstriction. However, the mechanism of the SCD enhanced vasoconstrictive response is unknown. We hypothesized that SCD induces enhanced alpha-1 adrenergic mediated vasoconstriction through the ET-1/ET A receptor pathway in arterial tissues. Utilizing humanized SCD (HbSS) and genetic...
View article titled, Enhanced <span class="search-highlight">vasoconstriction</span> in sickle cell disease is dependent on ET A receptor activation
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Includes: Supplementary data
Articles

Diminished Rbfox1 increases vascular constriction by dynamically regulating alternative splicing of Ca V 1.2 calcium channel in hypertension

Miaomiao Song, Wei Hou, Atta Ul Mustafa, Pengpeng Li, Jianzhen Lei, Yingying Zhou, Li Ji, Yu Sun, Hongmei Zhou, Yinyan Xu, Juejin Wang
Journal: Clinical Science
Clin Sci (Lond) (2022) 136 (11): 803–817.
https://doi.org/10.1042/CS20220226
Published: 30 May 2022
... channel in the neuronal development, but its potential roles in vascular Ca V 1.2 channels and vasoconstriction remain undefined. Here, we detect Rbfox1 is expressed in rat vascular smooth muscles. Moreover, the protein level of Rbfox1 is dramatically decreased in the hypertensive small arteries from...
View article titled, Diminished Rbfox1 increases vascular constriction by dynamically regulating alternative splicing of Ca V 1.2 calcium channel in hypertension
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Includes: Supplementary data
Articles

Angiotensin II potentiates α-adrenergic vasoconstriction in the elderly

Zachary Barrett-O’Keefe, Melissa A. H. Witman, John Mcdaniel, Anette S. Fjeldstad, Joel D. Trinity, Stephen J. Ives, Jamie D. Conklin, Van Reese, Sean Runnels, David E. Morgan, Mikael Sander, Russell S. Richardson, D. Walter Wray
Journal: Clinical Science
Clin Sci (Lond) (2013) 124 (6): 413–422.
https://doi.org/10.1042/CS20120424
Published: 27 November 2012
... through both the α-adrenergic and RAAS (renin–angiotensin–aldosterone) pathways. Although the independent contribution of these two pathways to elevated vasoconstriction with age may be substantial, significant cross-talk exists that could produce potentiating effects. To examine this interaction, 14...
View article titled, Angiotensin II potentiates α-adrenergic <span class="search-highlight">vasoconstriction</span> in the elderly
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Articles

Activated plasma coagulation β-Factor XII-induced vasoconstriction in rats

Peter C. Papageorgiou, Erik L. Yeo, Peter H. Backx, John S. Floras
Journal: Clinical Science
Clin Sci (Lond) (2012) 122 (12): 581–590.
https://doi.org/10.1042/CS20110517
Published: 05 March 2012
... (−38±8 μl) and HR [−18±5 b.p.m. (beats/min)] (all P <0.05). In 2ADX rats, β-FXIIa had no HR effect, but decreased SV (−89±9 μl) and MAP (−4±1 mmHg), and increased TPR by 66% (0.59±0.15 mmHg/ml per min) (all P <0.05). After infusion, adrenally intact rats exhibited persistent vasoconstriction (MAP...
View article titled, Activated plasma coagulation β-Factor XII-induced <span class="search-highlight">vasoconstriction</span> in rats
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Includes: Supplementary data
Articles

Native and oxidized low-density lipoproteins modulate the vasoactive actions of soluble β-amyloid peptides in rat aorta

Christopher C. T. Smith, Lee Stanyer, D. John Betteridge, Michael B. Cooper
Journal: Clinical Science
Clin Sci (Lond) (2007) 113 (11): 427–434.
https://doi.org/10.1042/CS20070082
Published: 01 November 2007
... is found in the circulation and enhances vasoconstriction. Under conditions that may favour the formation of short Aβ oligomers, as opposed to more severe polymerization leading to Aβ fibrillogenesis, we investigated the influence of LDLs on the vasoactive actions of soluble Aβ. Thus the actions of Aβ40...
View article titled, Native and oxidized low-density lipoproteins modulate the vasoactive actions of soluble β-amyloid peptides in rat aorta
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Articles

Reduced body mass index is associated with increased angiotensin II in young women with postural tachycardia syndrome

Julian M. Stewart, Indu Taneja, Marvin S. Medow
Journal: Clinical Science
Clin Sci (Lond) (2007) 113 (11): 449–457.
https://doi.org/10.1042/CS20070104
Published: 01 November 2007
... decreased body mass, but decreased body mass alone cannot account for findings of peripheral vasoconstriction. In conclusion, the findings suggest that reduced body mass relates to increased plasma AngII. © The Authors Journal compilation © 2007 Biochemical Society 2007 Correspondence: Professor...
View article titled, Reduced body mass index is associated with increased angiotensin II in young women with postural tachycardia syndrome
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Articles

Arterial adaptations to chronic changes in haemodynamic function: coupling vasomotor tone to structural remodelling

Dorota Dajnowiec, B. Lowell Langille
Journal: Clinical Science
Clin Sci (Lond) (2007) 113 (1): 15–23.
https://doi.org/10.1042/CS20060337
Published: 01 June 2007
... shear stress vasoconstriction vascular tone This review examines two modes of force-dependent arterial remodelling that have particular clinical significance. Relative wall thickening appropriately adapts the artery wall to the profound developmental increases in blood pressure that occur...
View article titled, Arterial adaptations to chronic changes in haemodynamic function: coupling vasomotor tone to structural remodelling
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Articles

Gender-related differences in the sympathetic vasoconstrictor drive of normal subjects

Andrew J. Hogarth, Alan F. Mackintosh, David A. S. G. Mary
Journal: Clinical Science
Clin Sci (Lond) (2007) 112 (6): 353–361.
https://doi.org/10.1042/CS20060288
Published: 12 February 2007
... gender muscle sympathetic nerve activity regional blood flow vasoconstriction The level of ABP (arterial blood pressure) and the incidence of cardiovascular disease, including hypertension, in middle-aged populations have been reported to be lower in women than in men [ 1 – 6 ]. However...
View article titled, Gender-related differences in the sympathetic vasoconstrictor drive of normal subjects
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Articles

Increased plasma angiotensin II in postural tachycardia syndrome (POTS) is related to reduced blood flow and blood volume

Julian M. Stewart, June L. Glover, Marvin S. Medow
Journal: Clinical Science
Clin Sci (Lond) (2006) 110 (2): 255–263.
https://doi.org/10.1042/CS20050254
Published: 17 January 2006
... with increased vasoconstriction related to decreased bioavailable NO (nitric oxide) have decreased blood volume. Ang II reduces bioavailable NO and is integral to the renin–Ang system. Thus, in the present study, we investigated the relationship between blood volume, Ang II, renin, aldosterone and peripheral...
View article titled, Increased plasma angiotensin II in postural tachycardia syndrome (POTS) is related to reduced blood flow and blood volume
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Articles

Contrasting neurovascular findings in chronic orthostatic intolerance and neurocardiogenic syncope

Julian M. STEWART, Amy WELDON
Journal: Clinical Science
Clin Sci (Lond) (2003) 104 (4): 329–340.
https://doi.org/10.1042/cs1040329
Published: 06 March 2003
... vasoconstriction venous resistance 329Clinical Science (2003) 104, 329 340 (Printed in Great Britain) Contrasting neurovascular findings in chronic orthostatic intolerance and neurocardiogenic syncope Julian M. STEWART* and Amy WELDON* *Department of Pediatrics, New York Medical College, Valhalla, NY 10595...
View article titled, Contrasting neurovascular findings in chronic orthostatic intolerance and neurocardiogenic syncope
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Articles

Orthostatic challenge reveals impaired vascular resistance control, but normal venous pooling and capillary filtration in familial dysautonomia

Clive M. BROWN, Brigitte STEMPER, Götz WELSCH, Miroslaw BRYS, Felicia B. AXELROD, Max J. HILZ
Journal: Clinical Science
Clin Sci (Lond) (2003) 104 (2): 163–169.
https://doi.org/10.1042/cs1040163
Published: 17 January 2003
... the patients (4.62±1.99ml·100ml -1 ) and the controls (3.18±0.74ml·100ml -1 ). The vasoconstrictor response to limb lowering was present in the patients (47.7±9.0% decrease in skin red-cell flux), but was impaired as compared with the controls (80.7±3.4%) ( P <0.05). The impaired vasoconstriction during...
View article titled, Orthostatic challenge reveals impaired vascular resistance control, but normal venous pooling and capillary filtration in familial dysautonomia
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Articles

Coronary responses to endothelin-1 and acetylcholine during partial coronary ischaemia and reperfusion in anaesthetized goats

Maria Angeles MARTÍNEZ, Nuria FERNÁNDEZ, Luis MONGE, Angel Luis GARCÍA-VILLALÓN, Elena SANZ, Godofredo DIÉGUEZ
Journal: Clinical Science
Clin Sci (Lond) (2002) 103 (s2002): 194S–197S.
https://doi.org/10.1042/CS103S194S
Published: 01 September 2002
...%. During this ischaemia, coronary vasodilatation to acetylcholine (0.003–0.1 µ g) and sodium nitroprusside (SNP; 1–10 µ g) was markedly reduced, and coronary vasoconstriction to ET-1 (0.01–0.3nmol) was attenuated. After 30min of reperfusion, coronary flow, mean arterial pressure and coronary vascular...
View article titled, Coronary responses to endothelin-1 and acetylcholine during partial coronary ischaemia and reperfusion in anaesthetized goats
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Articles

Effects of obesity on endothelium-dependent reactivity during acute nitric oxide synthase inhibition: modulatory role of endothelin

Tobias TRAUPE, Livius V. D'USCIO, Klaus MUENTER, Henning MORAWIETZ, Wilhelm VETTER, Matthias BARTON
Journal: Clinical Science
Clin Sci (Lond) (2002) 103 (s2002): 13S–15S.
https://doi.org/10.1042/CS103S013S
Published: 01 September 2002
.... In vascular rings from obese mice, contractility to acetylcholine was also evident in the aorta, and that in the carotid artery was increased compared with control mice. ET A receptor blockade by darusentan treatment of the obese mice prevented enhanced vasoconstriction to acetylcholine, resulting in mild...
View article titled, Effects of obesity on endothelium-dependent reactivity during acute nitric oxide synthase inhibition: modulatory role of endothelin
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Articles

Selective enhancement of sensitivity to endothelin-1 despite normal endothelium-dependent relaxation in subcutaneous resistance arteries isolated from patients with Type I diabetes

Carol-Ann MCINTYRE, Patrick W. F. HADOKE, Brent C. WILLIAMS, R. Mark LINDSAY, Andrew I. ELLIOTT, John A. MCKNIGHT
Journal: Clinical Science
Clin Sci (Lond) (2001) 100 (3): 311–318.
https://doi.org/10.1042/cs1000311
Published: 02 February 2001
... complications. Correspondence : Dr Patrick W. F. Hadoke (e-mail [email protected] ). 26 6 2000 26 10 2000 17 11 2000 The Biochemical Society and the Medical Research Society © 2001 2001 endothelium human resistance arteries Type I diabetes vasoconstriction...
View article titled, Selective enhancement of sensitivity to endothelin-1 despite normal endothelium-dependent relaxation in subcutaneous resistance arteries isolated from patients with Type I diabetes
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Articles

Cytochrome P450 metabolites of arachidonic acid may be important mediators in angiotensin II-induced vasoconstriction in the rat mesentery in vivo

Z. M. CHU, K. D. CROFT, D. A. KINGSBURY, J. R. FALCK, K. M. REDDY, L. J. BEILIN
Journal: Clinical Science
Clin Sci (Lond) (2000) 98 (3): 277–282.
https://doi.org/10.1042/cs0980277
Published: 09 February 2000
... combined with the existing evidence that angiotensin II stimulates the release of 20-HETE, a CYP-450 metabolite of arachidonic acid, suggest that CYP-450-derived HETEs may be important mediators in angiotensin II-induced vasoconstriction. However, the development of more sensitive assays for the detection...
View article titled, Cytochrome P450 metabolites of arachidonic acid may be important mediators in angiotensin II-induced <span class="search-highlight">vasoconstriction</span> in the rat mesentery in vivo
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Articles

Cardiovascular responses evoked by mild cool stimuli in primary Raynaud's disease: the role of endothelin

Clare M. EDWARDS, Janice M. MARSHALL, M. PUGH
Journal: Clinical Science
Clin Sci (Lond) (1999) 96 (6): 577–588.
https://doi.org/10.1042/cs0960577
Published: 04 May 1999
...Clare M. EDWARDS; Janice M. MARSHALL; M. PUGH In control subjects and in subjects with primary Raynaud's disease, sudden sound evokes the pattern of the alerting response, which includes cutaneous vasoconstriction and vasodilatation in forearm muscle. However, whereas this pattern of response...
View article titled, Cardiovascular responses evoked by mild cool stimuli in primary Raynaud's disease: the role of endothelin
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Articles

Impaired skin vasomotor reflexes in patients with erythromelalgia

Roberta C. LITTLEFORD, Faisel KHAN, Jill J. F. BELCH
Journal: Clinical Science
Clin Sci (Lond) (1999) 96 (5): 507–512.
https://doi.org/10.1042/cs0960507
Published: 14 April 1999
... in the pathophysiology of EM. Correspondence : Dr Faisel Khan 5 10 1998 8 1 1999 15 1 1999 The Biochemical Society and the Medical Research Society © 1999 1999 erythromelalgia laser Doppler flowmetry skin sympathetic activity vasoconstriction 507Clinical Science (1999) 96, 507ñ512...
View article titled, Impaired skin vasomotor reflexes in patients with erythromelalgia
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Articles

Investigation of distal aortic compliance and vasodilator responsiveness in heart failure due to proximal aortic stenosis in the guinea pig

Martyn P. KINGSBURY, Wenxin HUANG, Silvana GIULIATTI, Mark TURNER, Ross HUNTER, Kim PARKER, Desmond J. SHERIDAN
Journal: Clinical Science
Clin Sci (Lond) (1999) 96 (3): 241–251.
https://doi.org/10.1042/cs0960241
Published: 01 March 1999
... heart failure vasoconstriction vasodilatation 241Clinical Science (1999) 96, 241 251 (Printed in Great Britain) Investigation of distal aortic compliance and vasodilator responsiveness in heart failure due to proximal aortic stenosis in the guinea pig Martyn P. KINGSBURY, Wenxin HUANG, Silvana...
View article titled, Investigation of distal aortic compliance and vasodilator responsiveness in heart failure due to proximal aortic stenosis in the guinea pig
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Articles

α-Adrenoceptor Mechanisms of Thermoregulation during Cold Challenge in Humans

Steven M. Frank, Nader El-Gamal, Srinivasa N. Raja, Peter K. Wu
Journal: Clinical Science
Clin Sci (Lond) (1996) 91 (5): 627–631.
https://doi.org/10.1042/cs0910627
Published: 01 November 1996
... assigned treatments: (i) control (no drug), (ii) low-dose phentolamine, and (iii) high-dose phentolamine. On each day cold intravenous saline (4°C) was given until both vasoconstriction and shivering were triggered or a maximum fluid volume (40 ml/kg) was delivered. Core temperature, peripheral...
View article titled, α-Adrenoceptor Mechanisms of Thermoregulation during Cold Challenge in Humans
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Articles

Mechanism of reserpine-induced acute gastric mucosal injury in the rat: role of endogenous 5-hydroxytryptamine

Aws S. Saum
Journal: Clinical Science
Clin Sci (Lond) (1991) 80 (1): 59–64.
https://doi.org/10.1042/cs0800059
Published: 01 January 1991
...Aws S. Saum 1. Reserpine (5 mg/kg intraperitoneally) produced gastric mucosal vasoconstriction and injury in all rats within 6 h (injury score 38.8 ± 2.1 mm 2 , mean ± SEM). Coeliac ganglionectomy or the β-adrenoceptor-blocking drug propranolol (5–15 mg/kg) did not influence these effects...
View article titled, Mechanism of reserpine-induced acute gastric mucosal injury in the rat: role of endogenous 5-hydroxytryptamine
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Articles

Postural vasoconstriction in women during the normal menstrual cycle

Ahmad A. K. Hassan, G. Carter, J. E. Tooke
Journal: Clinical Science
Clin Sci (Lond) (1990) 78 (1): 39–47.
https://doi.org/10.1042/cs0780039
Published: 01 January 1990
...Ahmad A. K. Hassan; G. Carter; J. E. Tooke 1. Postural vasoconstriction in the foot was examined in 15 women during the menstrual, follicular and luteal phases of the menstrual cycle, and in 13 age-matched men on two separate occasions, in a constant-temperature environment (22°C). 2. Skin blood...
View article titled, Postural <span class="search-highlight">vasoconstriction</span> in women during the normal menstrual cycle
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Articles

Effects of Underfeeding and of Starvation on Thermoregulatory Responses to Cooling in Women

P. I. Mansell, I. A. Macdonald
Journal: Clinical Science
Clin Sci (Lond) (1989) 77 (3): 245–252.
https://doi.org/10.1042/cs0770245
Published: 01 September 1989
..., a fall occurred after starvation. 3. Underfeeding for 7 days did not affect thermogenesis or the degree of vasoconstriction in the forearm or hand in response to cooling. 4. After 48 h starvation, the thermogenic response to cooling was abolished and blood flow in the forearm remained higher than...
View article titled, Effects of Underfeeding and of Starvation on Thermoregulatory Responses to Cooling in Women
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Articles

Effects of infusion of prostacyclin on anatomical intrapulmonary right to left shunt: a useful model of human hypoxic vasoconstriction?

A. Bush, C. M. Busst, W. B. Knight, E. A. Shinebourne
Journal: Clinical Science
Clin Sci (Lond) (1989) 76 (2): 143–149.
https://doi.org/10.1042/cs0760143
Published: 01 February 1989
...% oxygen and general anaesthesia causing alveolar collapse, with only partial compensation for impairment of gas exchange by compensatory local hypoxic vasoconstriction. 3. When prostacyclin was infused, pulmonary vascular resistance fell by 3.2 ± 1.8 units (mmHg litre −1 min m 2 ), and pulmonary blood...
View article titled, Effects of infusion of prostacyclin on anatomical intrapulmonary right to left shunt: a useful model of human hypoxic <span class="search-highlight">vasoconstriction</span>?
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Articles

Mechanism of the postural vasoconstrictor response in the human foot

Ahmad A. K. Hassan, J. E. Tooke
Journal: Clinical Science
Clin Sci (Lond) (1988) 75 (4): 379–387.
https://doi.org/10.1042/cs0750379
Published: 01 October 1988
...Ahmad A. K. Hassan; J. E. Tooke 1. The mechanism of postural vasoconstriction in the skin of the foot was examined in 102 healthy subjects by using laser Doppler flowmetry. 2. In 45 subjects, when one foot was lowered 50 cm below heart level and the other foot kept horizontal, blood flow...
View article titled, Mechanism of the postural vasoconstrictor response in the human foot
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Articles

Hypoxic pulmonary vasoconstriction persists in the human transplanted lung

Eugene D. Robin, James Theodore, Conor M. Burke, Stephen N. Oesterle, Michael B. Fowler, Stuart W. Jamieson, John C. Baldwin, Adrian J. Morris, Sharon A. Hunt, Antonius Vankessel, Edward B. Stinson, Norman E. Shumway
Journal: Clinical Science
Clin Sci (Lond) (1987) 72 (3): 283–287.
https://doi.org/10.1042/cs0720283
Published: 01 March 1987
...Eugene D. Robin; James Theodore; Conor M. Burke; Stephen N. Oesterle; Michael B. Fowler; Stuart W. Jamieson; John C. Baldwin; Adrian J. Morris; Sharon A. Hunt; Antonius Vankessel; Edward B. Stinson; Norman E. Shumway 1. The preservation of hypoxic pulmonary vasoconstriction (HPV) in the denervated...
View article titled, Hypoxic pulmonary <span class="search-highlight">vasoconstriction</span> persists in the human transplanted lung
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Articles

Effects of ethanol ingestion on blood pressure reactivity

G. Eisenhofer, D. G. Lambie, R. H. Johnson
Journal: Clinical Science
Clin Sci (Lond) (1987) 72 (2): 251–254.
https://doi.org/10.1042/cs0720251
Published: 01 February 1987
... The Biochemical Society and the Medical Research Society 1970 α-adrenoceptor blood pressure catecholamines ethanol vasoconstriction Clinical Science (1987) 72 , 25 1-254 SHORT COMMUNICATION 251 Effects of ethanol ingestion on blood pressure reactivity G. EISENHOFER*, D. G. LAMBIE AND R. H. JOHNSON...
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Articles

Neuropeptide Y: a novel renal peptide with vasoconstrictor and natriuretic activity

J. M. Allen, A. E. G. Raine, J. G. G. Ledingham, S. R. Bloom
Journal: Clinical Science
Clin Sci (Lond) (1985) 68 (4): 373–377.
https://doi.org/10.1042/cs0680373
Published: 01 April 1985
.... 31 8 1984 8 10 1984 © 1985 The Biochemical Society and the Medical Research Society 1985 isolated perfused rat kidney natriuresis neuropeptide Y sympathetic neurons vasoconstriction Clinical Science (1985) 68, 373-377 373 Neuropeptide Y: a novel renal peptide...
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Articles

Decrease in α-Adrenoceptor-Mediated Vasoconstriction Parallels the Antihypertensive Response to Propranolol in Patients with Normal Renin Essential Hypertension

F. W. Amann, P. Bolli, L. Hulthén, W. Kiowski, F. R. Bühler
Journal: Clinical Science
Clin Sci (Lond) (1981) 61 (s7): 445s–448s.
https://doi.org/10.1042/cs061445s
Published: 01 December 1981
...F. W. Amann; P. Bolli; L. Hulthén; W. Kiowski; F. R. Bühler 1. α 1 -Adrenoceptor-mediated vasoconstriction was studied before and during propranolol therapy in eight normal renin essential hypertensive patients; four were known ‘responders’ and four, age-matched ‘non-responders’ to previous β...
View article titled, Decrease in α-Adrenoceptor-Mediated <span class="search-highlight">Vasoconstriction</span> Parallels the Antihypertensive Response to Propranolol in Patients with Normal Renin Essential Hypertension
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Articles

State of the Art Review: Role of Vasopressin in Cardiovascular Homeostasis and Hypertension

C. I. Johnston, M. Newman, R. Woods
Journal: Clinical Science
Clin Sci (Lond) (1981) 61 (s7): 129s–139s.
https://doi.org/10.1042/cs061129s
Published: 01 December 1981
...C. I. Johnston; M. Newman; R. Woods © 1981 The Biochemical Society and the Medical Research Society 1981 antidiuretic hormone haemorrhage orthostasis vasoconstriction vasopressin CIinicalScience (1981) 61, 1 2 9 ~ 1 3 9 s 129s STATE OF THE ART REVIEW Role of vasopressin...
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Articles

Captopril Attenuates Adrenergic Vasoconstriction in Rat Mesenteric Arteries by Angiotensin-Dependent and -Independent Mechanisms

M. G. Collis, J. R. Keddie
Journal: Clinical Science
Clin Sci (Lond) (1981) 61 (3): 281–286.
https://doi.org/10.1042/cs0610281
Published: 01 September 1981
...M. G. Collis; J. R. Keddie 1. Angiotensin-converting enzyme inhibitors can attenuate reflex sympathetic vasoconstriction in vivo. We have investigated the effects of captopril (SQ 14 225) on adrenergic vasoconstrictor mechanisms in isolated, Krebs-Ringer solution perfused, rat mesenteric arteries...
View article titled, Captopril Attenuates Adrenergic <span class="search-highlight">Vasoconstriction</span> in Rat Mesenteric Arteries by Angiotensin-Dependent and -Independent Mechanisms
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Articles

Inhibition by Bradykinin of the Vascular Effects of Pressor Hormones in the Canine Kidney: Relationship to Prostaglandins

H. Sušić, A. Nasjletti, K. U. Malik
Journal: Clinical Science
Clin Sci (Lond) (1980) 59 (s6): 145s–148s.
https://doi.org/10.1042/cs059145s
Published: 01 December 1980
...H. Sušić; A. Nasjletti; K. U. Malik 1. Renal arterial injection of bolus doses of angiotensin II or noradrenaline, (0.06, 0.12 and 0.25 μg) caused renal vasoconstriction and decreased blood flow to the kidney in a dose-related manner in dogs anaesthetized by sodium pentobarbital. 2. The effect...
View article titled, Inhibition by Bradykinin of the Vascular Effects of Pressor Hormones in the Canine Kidney: Relationship to Prostaglandins
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Articles

A Circulating Humoral Pressor Agent in Dahl S Rats with Salt Hypertension

L. Tobian, Mary Pumper, Susan Johnson, J. Iwai
Journal: Clinical Science
Clin Sci (Lond) (1979) 57 (s5): 345s–347s.
https://doi.org/10.1042/cs057345s
Published: 01 December 1979
...L. Tobian; Mary Pumper; Susan Johnson; J. Iwai 1. In Dahl S rats becoming hypertensive while on a diet of high NaCl content there appears to be a blood-borne humoral agent which produces vasoconstriction in a bioassay using the isolated hindquarters of rats. 2. This vasoconstrictor effect strongly...
View article titled, A Circulating Humoral Pressor Agent in Dahl S Rats with Salt Hypertension
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Articles

α-Adrenergic Suppression of Renin Secretion in the Rat Independent of Renal Vasoconstriction

R. Vandongen, K. D. Strang, Marianne H. Poesse, W. H. Birkenhager
Journal: Clinical Science
Clin Sci (Lond) (1979) 57 (s5): 161s–163s.
https://doi.org/10.1042/cs057161s
Published: 01 December 1979
... renin secretion in response to isoprenaline. 3. Renal vasoconstriction was abolished and the response in renin secretion to isoprenaline was restored by α-adrenoreceptor blockade with phenoxybenzamine. 4. In contrast, when renal vasoconstriction was prevented by dihydrallazine, suppression of renin...
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