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1-31 of 31
Keywords: vasodilatation
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Articles
Journal:
Clinical Science
Clin Sci (Lond) (2011) 120 (11): 485–491.
Published: 15 February 2011
... in several pathologies associated with human aging, including hypertension, Type 2 diabetes and coronary artery disease. However, it is currently unknown whether the decline in endothelial vasodilatation with advancing age is due to elevated ET-1 vasconstrictor activity. Accordingly, we tested the hypothesis...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2005) 109 (1): 45–54.
Published: 23 June 2005
... cyclo-oxygenase prostanoid Raynaud's disease vasodilatation Raynaud's phenomenon was first described by Maurice Raynaud more than 100 years ago as vasospasm that generally occurs in the fingers and is precipitated by cold or emotional stress. Since then, the diagnosis has been refined to more...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2005) 108 (1): 65–72.
Published: 15 December 2004
.../min), acetylcholine (5–20 μg/min) and sodium nitroprusside (2–8 μg/min) infusions. All vasodilators caused dose-dependent increases in infused FBF ( P <0.05). Patients in the upper homocysteine quartile (16.8±2.9 compared with 7.9±0.7 μmol/l; P =0.003) had reduced vasodilatation to acetylcholine...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2004) 107 (3): 323–330.
Published: 24 August 2004
...Ross G. HENDRY; Janice M. MARSHALL In healthy young men (age, 20–22 years), we tested the role of prostanoids produced by the COX (cyclo-oxygenase) pathway in cutaneous vasodilatation evoked in the finger by ACh (acetylcholine). To this end, changes in cutaneous RCF (red cell flux), recorded...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2004) 107 (2): 149–158.
Published: 27 July 2004
... receptor). In the present study, we have investigated the mechanism of testosterone-induced vasodilatation using isolated rat coronary arteries and thoracic aortae from control and AR-deficient testicular-feminized mice. Vasodilatation induced by testosterone, T-3-OCMO [testosterone 3-( O -carboxymethyl...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2003) 105 (5): 533–535.
Published: 01 November 2003
... the pharmacokinetic behaviour of these drugs should be of interest in developing NO donors for clinical use. © 2003 The Biochemical Society 2003 15 7 2003 1 8 2003 1 8 2003 nitric oxide S-nitrosated thiosugar skin vasodilatation Clinical Science (2003) 105, 533 535 (Printed in Great...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2003) 105 (5): 577–584.
Published: 01 November 2003
[email protected] ). 22 4 2003 19 6 2003 1 7 2003 1 7 2003 © 2003 The Biochemical Society 2003 nitric oxide skin S-nitrosated thiosugar vasodilatation Clinical Science (2003) 105, 577 584 (Printed in Great Britain) 577 Chemical synthesis and microvascular effects of new...
Articles
Jens PASSAUER, Eckhart BÜSSEMAKER, Grit LÄSSIG, Frank PISTROSCH, Joachim FAULER, Peter GROSS, Ingrid FLEMING
Journal:
Clinical Science
Clin Sci (Lond) (2003) 105 (4): 513–518.
Published: 01 October 2003
... ). 27 3 2003 4 6 2003 24 6 2003 26 6 2003 © 2003 The Biochemical Society 2003 bradykinin cytochrome P450 endothelium-derived hyperpolarizing factor forearm sulphaphenazole vasodilatation Clinical Science (2003) 105, 513 518 (Printed in Great Britain) 513 Baseline...
Articles
Maria Angeles MARTÍNEZ, Nuria FERNÁNDEZ, Luis MONGE, Angel Luis GARCÍA-VILLALÓN, Elena SANZ, Godofredo DIÉGUEZ
Journal:
Clinical Science
Clin Sci (Lond) (2002) 103 (s2002): 194S–197S.
Published: 01 September 2002
...%. During this ischaemia, coronary vasodilatation to acetylcholine (0.003–0.1 µ g) and sodium nitroprusside (SNP; 1–10 µ g) was markedly reduced, and coronary vasoconstriction to ET-1 (0.01–0.3nmol) was attenuated. After 30min of reperfusion, coronary flow, mean arterial pressure and coronary vascular...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (1999) 96 (5): 467–474.
Published: 25 March 1999
...Florence WONG; Arieh BOMZON; Johane ALLARD; Peter LIU; Laurence BLENDIS Systemic arterial vasodilatation has been implicated in the pathogenesis of sodium retention in cirrhosis. Hydrophobic bile acids, which have vasodilatory actions, may be involved. Ursodeoxycholic acid, a hydrophilic bile acid...
Articles
Martyn P. KINGSBURY, Wenxin HUANG, Silvana GIULIATTI, Mark TURNER, Ross HUNTER, Kim PARKER, Desmond J. SHERIDAN
Journal:
Clinical Science
Clin Sci (Lond) (1999) 96 (3): 241–251.
Published: 01 March 1999
... heart failure vasoconstriction vasodilatation 241Clinical Science (1999) 96, 241 251 (Printed in Great Britain) Investigation of distal aortic compliance and vasodilator responsiveness in heart failure due to proximal aortic stenosis in the guinea pig Martyn P. KINGSBURY, Wenxin HUANG, Silvana...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (1998) 94 (6): 601–607.
Published: 01 June 1998
...Jonas Millgård; Lars Lind 1. Previous investigations have demonstrated an impaired endothelium-dependent vasodilatation (EDV) in patients with hypertension. The present study aimed to investigate if an acute rise in blood pressure to hypertensive levels impairs EDV in otherwise normotensive...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (1996) 91 (5): 567–573.
Published: 01 November 1996
... hypercholesterolaemia, overt hypertension or microproteinuria. 2. We examined endogenous and exogenous nitric oxide-mediated vasodilatation by measuring forearm blood flow with venous occlusive plethysmography after administration of acetylcholine (7.5 and 15 μg/min) and sodium nitroprusside (3 and 10 μg/min...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (1995) 88 (6): 643–649.
Published: 01 June 1995
... conductance values obtained immediately and every 15 s after occlusion cuff release for 165 s, revealed differences in the pattern of vasodilatation after occlusion and ischaemic exercise. Maximal calf vascular conductance was more sustained after ischaemic exercise, and the shape of the calf vascular...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (1995) 88 (5): 519–524.
Published: 01 May 1995
... words: acetylcholine, bradykinin, diabetes mellitus, endothelium, nitric oxide, resistance artery, vasodilatation. Abbreviations: ACh, acetylcholine; KPSS. PSS with KCI substituted for NaCI; L-NAME. N;nitrN-arginine methyl ester; NAK, 5pmol/l noradrenaline in KPSS; NO, nitric oxide; PKC. protein kinase...
Articles
Tim L. Th. A. Jansen, Dr Paul Smits, Jacques W. M. Lenders, Marie-Cécile G. S. Jacobs, Jacques Willemsen, Theo Thien
Journal:
Clinical Science
Clin Sci (Lond) (1994) 86 (3): 275–283.
Published: 01 March 1994
... Research Society 1994 atrial natriuretic factor forearm vascular resistance lower body negative pressure vasodilatation Clinical Science (1994) 86, 275-283 (Printed in Great Britain) 275 Atrial natriuretic factor potentiates the human forearm vasoconstrictor response to sympathetic stimulation...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (1993) 85 (1): 51–55.
Published: 01 July 1993
... vascular resistance (ratio between mean arterial blood pressure and forearm blood flow) during three interventions: postocclusive forearm hyperaemia, intrabrachial infusion of methacholine which causes vasodilatation by stimulating the release of endothelium-dependent relaxing factor, and intrabrachial...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (1993) 84 (6): 581–584.
Published: 01 June 1993
...John B. Warren © 1993 The Biochemical Society and the Medical Research Society 1993 cyclic AMP endothelium inflammation microcirculation nitric oxide oedema permeability vasodilatation Clinical Science (1993) 84, 581-584 (Printed in Great Britain) Editorial Review 581 Vascular...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (1991) 81 (3): 427–432.
Published: 01 September 1991
... function. This does not, however, preclude further modification by additional stimuli generated in vivo. 11 4 1991 23 4 1991 © 1991 The Biochemical Society and the Medical Research Society 1991 amino acids indomethacin kidney nitric oxide sulpiride vasodilatation Clinical...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (1991) 80 (5): 435–441.
Published: 01 May 1991
...G. A. Burton; J. Haylor; A. de Jonge 1. The sensitivity of the kidney to endothelium-derived-relaxing-factor-mediated vasodilatation has been investigated in the spontaneously hypertensive rat and the Wistar-Kyoto normotensive rat using an isolated perfused rat kidney model. 2. No difference...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (1990) 79 (4): 381–386.
Published: 01 October 1990
...) but remained unaffected by l-leucine. The vasodilatation induced by l-arginine hydrochloride and sodium glutamate was not sustained. 5. The time-dependent fall in [ 14 C]inulin clearance was prevented by glycine, l-arginine and glutamic acid, but not by l-leucine. l-Arginine hydrochloride, like the mixed amino...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (1988) 75 (3): 309–313.
Published: 01 September 1988
... of the hyperaemic response. 4. Human A- and B-calcitonin-gene-related peptides are therefore potent vasodilators in man, causing comparable dose-related vasodilatation in the superficial tissues. 14 1 1988 23 2 1988 © 1970 The Biochemical Society and the Medical Research Society 1970 blood...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (1988) 74 (2): 207–211.
Published: 01 February 1988
... concentration-dependent relaxation of isolated human arteries, including brachial artery, but was without effect on isolated human saphenous vein. 5. ANP produces vasodilatation in vivo and relaxes isolated human arterial smooth muscle. This action of ANP may contribute to its reported hypotensive effects...
Articles
A. D. Struthers, M. J. Brown, D. W. R. Macdonald, J. L. Beacham, J. C. Stevenson, H. R. Morris, I. Macintyre
Journal:
Clinical Science
Clin Sci (Lond) (1986) 70 (4): 389–393.
Published: 01 April 1986
..., CGRP produces vasodilatation and complex changes in plasma calcium. 2. We have now assessed its biological activity in man by infusing human CGRP (hCGRP) into six normal volunteers. hCGRP (545 pmol/min) caused the diastolic pressure to fall from 64 ± 5 to 55 ± 7mmHg ( P < 0.05), the heart rate...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (1982) 63 (s8): 81s–82s.
Published: 01 October 1982
... of a multichannel video-angiometer under resting conditions and under maximal vasodilatation induced by hypercapnia. 2. Initial mean arterial pressure was 172 ± sem 9 mmHg in SHR and 103 ± 5 mmHg in WKY rats; during hypercapnia the corresponding values were 183 ± 9 and 127 ± 7 mmHg. 3. The resting diameter...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (1981) 61 (s7): 319s–321s.
Published: 01 December 1981
... creatinine clearance. 5. Urinary prostaglandin E 2 was reduced by diclofenac. 6. We suggest that dihydralazine-mediated vasodilatation is reduced by cyclo-oxygenase inhibition. © 1981 The Biochemical Society and the Medical Research Society 1981 diclofenac dihydralazine prostaglandins...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (1981) 61 (s7): 477s–479s.
Published: 01 December 1981
... and arteries are potentially useful for the treatment of both coronary heart disease and of arterial hypertension. © 1981 The Biochemical Society and the Medical Research Society 1981 β-adrenoceptor blockade BM 12.434 isosorbide-5-mononitrate metipranolol vasodilatation Clinical Science (1981...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (1979) 57 (s5): 433s–436s.
Published: 01 December 1979
... of precapillary vasodilatation, particularly in the renal and coronary vasculatures. 3. The β-adrenoreceptor-blocking actions of SK&F 92657 prevent reflex cardiac stimulation. β-adrenoreceptor blockade antihypertensive drugs regional blood flow SK&F 92657 vasodilatation © 1979 The Biochemical...
Articles
Journal:
Clinical Science
Clin Sci Mol Med (1978) 55 (s4): 195s–198s.
Published: 01 December 1978
... and contribute to the regulation of blood vessel tone and blood pressure. © 1978 The Biochemical Society and the Medical Research Society 1978 arachidonic acid prostacyclin (PGI 2 ) pulmonary circulation thromboxane A 2 vasodilatation vascular tone Clinical Science and Molecular Medicine (1978...
Articles
Journal:
Clinical Science
Clin Sci Mol Med (1977) 53 (4): 349–354.
Published: 01 October 1977
... 1977 blood transfusion blood volume cardiac output central blood pressures electromagnetic flowmeter leg blood flow neuroleptanaesthesia vasodilatation Clinical Science and Molecular Medicine (1977) 53, 349-354. Leg blood flow and central circulation at various blood volumes...
Articles
Journal:
Clinical Science
Clin Sci (1972) 42 (5): 535–543.
Published: 01 May 1972
...S. G. Massry; J. J. Ahumada 1. The effect of unilateral renal vasodilatation produced by acetylcholine or bradykinin on free water clearance (C H2O ) and free water reabsorption (T c H2O ) was investigated in dogs in an effort to localize the site(s) in the nephron where renal vasodilatation...
