... in spontaneously hypertensive rats and additionally prevents mortality in renal (two-kidney, one-clip) and salt-induced (Dahl salt-sensitive) hypertensive rats. 2. Vasodilators of the hydralazine type only lower blood pressure in spontaneous hypertensive rats but do not influence cardiac hypertrophy. Minoxidil...

..., mean arterial pressure during the manoeuvre decreased significantly, indicating impairment of reflex constrictor response. 4. These findings support the proposition that the angiotensin II response normally limits the fall in blood pressure during vasodilator therapy. We conclude that the greater fall...

...G. Leonetti; Laura Terzoli; Carla Sala; C. Bianchini; A. Zanchetti 1. The antihypertensive effect of the new drug, SKF 92 657, a hydrazinopyridazine derivative, possessing both β-adrenoreceptor-blocking and vasodilating properties, was investigated in essential hypertension. 2. Single oral doses...

...R. C. Tarazi; H. P. Dustan; E. L. Bravo; A. P. Niarchos 1. We investigated the haemodynamic effects of intravenously administered hydrallazine, diazoxide and nitroprusside and orally administered minoxidil to determine whether vasodilators (such as nitroprusside) which do not increase cardiac...

...Priscilla Kincaid-Smith; A. S. P. Hua; J. B. Myers; Ileene Macdonald; P. Fang 1. Two vasodilators, prazosin and hydrallazine, have been compared in three double-blind cross-over studies designed to test their effect when used in combination with a β-adrenoceptor-blocking agent and a thiazide. 2...

... flow. 2. Renal vascular resistance increased with increasing age in the normal subjects. A significant inverse relationship was found between the initial vascular resistance and the renal vasodilator response to dopamine. It thus appears that the vascular effects of increasing age (nephrosclerosis) may...