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Clin Sci (Lond) (2006) 110 (6): 683–692.
Published: 15 May 2006
... muscle. 28 7 2005 25 1 2006 27 2 2006 27 2 2006 The Biochemical Society 2006 acute mountain sickness acetazolamide fatigue hypoxia isolated muscle exercise metabolic acidosis ventilation V ̇ O 2 peak was determined during continuous graded bicycle exercise...
Beth A. BEIDLEMAN, Stephen R. MUZA, Charles S. FULCO, Allen CYMERMAN, Dan DITZLER, Dean STULZ, Janet E. STAAB, Gary S. SKRINAR, Steven F. LEWIS, Michael N. SAWKA
Clin Sci (Lond) (2004) 106 (3): 321–328.
Published: 01 March 2004
... by a few days of chronic residence at the same altitude. Increased ventilation and diuresis may contribute to the reduction in AMS with altitude acclimatization. The aim of the present study was to examine the effects of intermittent altitude exposures (IAE), in combination with rest and exercise training...
Clin Sci (Lond) (2000) 99 (3): 223–230.
Published: 16 August 2000
...Stuart D. R. GALLOWAY; Giuseppe DE VITO; Sam McCLURE; Myra A. NIMMO; John J. V. McMURRAY Augmentation of circulating noradrenaline concentration stimulates ventilation during the initial stages of exercise and this is accompanied by an increased sensation of dyspnoea and exertion. This previous...
Clin Sci (Lond) (1996) 91 (3): 337–345.
Published: 01 September 1996
...Ken D. O'halloran; Aidan K. Curran; Aidan Bradford 1. Ventilation was measured during normoxia, hypoxia and hypercapnia before and after administration of almitrine in conscious, unrestrained, tracheostomized rats with the superior laryngeal nerves intact or cut. In superior laryngeal nerve-intact...
Clin Sci (Lond) (1995) 88 (3): 325–330.
Published: 01 March 1995
... pulmonary disease. These changes have been attributed to the anti-inflammatory properties of the drug. However, airways function can be improved by other means, e.g. improved ventilation/perfusion ratio or reduced airways resistance. The possibility that fenspiride may have actions other than anti...
Clin Sci (Lond) (1992) 83 (4): 391–397.
Published: 01 October 1992
...Larry C. Lands; George J. F. Heigenhauser; Norman L. Jones 1. Maximal exercise capacity in cystic fibrosis is influenced by both pulmonary and nutritional factors: lung disease by limiting maximal achievable ventilation, and malnutrition through a loss of muscle mass. The associated reduction...
Clin Sci (Lond) (1990) 78 (6): 541–545.
Published: 01 June 1990
... oxygen saturation, mean ventilation was significantly lower in the less obese state. Similarly to hypercapnic responses, there were no statistically significant changes in ventilatory pattern despite the changes in overall ventilatory response. 5. We conclude that ventilatory responsiveness to chemical...
Clin Sci (Lond) (1988) 74 (5): 531–537.
Published: 01 May 1988
... and minute ventilation such that it could be a secondary response to either. However, during and after inspiration of 15% O 2 , changes in breathlessness occurred relatively more quickly than those in ventilation, more closely reflecting changes in oxygen saturation; this suggests that hypoxia, per se...
K. Murphy, R. P. Stidwill, Brenda A. Cross, Kathryn D. Leaver, E. Anastassiades, M. Phillips, A. Guz, S. J. G. Semple
Clin Sci (Lond) (1987) 73 (6): 617–625.
Published: 01 December 1987
...K. Murphy; R. P. Stidwill; Brenda A. Cross; Kathryn D. Leaver; E. Anastassiades; M. Phillips; A. Guz; S. J. G. Semple 1. Continuous recordings of arterial pH, ventilation, airway CO 2 and heart rate were made during rest and during 3–4 min periods of rhythmic leg exercise in four renal patients...
Clin Sci (Lond) (1987) 73 (3): 311–318.
Published: 01 September 1987
... and later copied these breathing patterns. 2. During all experiments flow, ventilation and pleural pressures were recorded. In addition, breathlessness was measured on a visual analogue scale every 30 s. 3. In these patients voluntary copying of either form of stimulated breathing resulted in diminished...
R. M. Schwartzstein, K. La Hive, A. Pope, R. A. Steinbrook, D. E. Leith, J. W. Weiss, V. Fencl, S. E. Weinberger
Clin Sci (Lond) (1987) 73 (3): 333–335.
Published: 01 September 1987
...R. M. Schwartzstein; K. La Hive; A. Pope; R. A. Steinbrook; D. E. Leith; J. W. Weiss; V. Fencl; S. E. Weinberger 1. To investigate whether changes in P a co 2 can be detected independently of the CO 2 -induced changes in pulmonary ventilation, we tested five normal subjects for the ability...
Clin Sci (Lond) (1987) 73 (2): 177–182.
Published: 01 August 1987
... chamber in the inspiratory limb of a breathing circuit. 2. The time course of the response of ventilation ( V ) and mean alveolar P co 2 ( P aco 2 ) was checked in separate experiments, where the flow rate of injected CO 2 was changed abruptly and the effects were followed for 10 min. 3. V and P aco 2...
Clin Sci (Lond) (1987) 72 (6): 693–698.
Published: 01 June 1987
... arterial oxygen desaturation during the exercise. 2. During the exercises, ventilation was recorded and patients recorded their sensation of breathlessness on a visual analogue scale (VAS) every 30 s. 3. Breathing supplemental oxygen produced a small fall in mean exercise ventilation and a large...
Clin Sci (Lond) (1986) 71 (1): 17–22.
Published: 01 July 1986
... circuit. 2. Ventilation ( V ) was measured with a dry gas meter and Pco 2 at the mouth was recorded by a mass spectrometer. Mean alveolar P co 2 ( P aco 2 ) was taken as equal to end-tidal P co 2 at rest, and during exercise was derived graphically from the sloping alveolar plateaus. The accuracy...
Clin Sci (Lond) (1986) 70 (6): 547–554.
Published: 01 June 1986
... somatostatin ventilation © 1986 The Biochemical Society and the Medical Research Society 1986 9 12 1985 7 1 1986 ClinicalScience( 1986) 70, 547-554 541 Effects of somatostatin, naloxone and prochlorperazine on the control of ventilation in man D. L. MAXWELL, K. B. NOLOP AND J. M. B...
Clin Sci (Lond) (1986) 70 (6): 555–564.
Published: 01 June 1986
...J. M. B. Hughes; D. J. Allison; A. Goatcher; A. Tripathi 1. Almitrine bismesylate (5–10 μg/kg) was given as an intravenous bolus to anaesthetized, paralysed dogs (a) with closed-chest ( n = 5) and (b) with open-chest ( n = 7) in whom the retrocardiac lobe was separately ventilated. Pulmonary, lobar...
Clin Sci (Lond) (1984) 67 (5): 515–519.
Published: 01 November 1984
... in a blind randomized study. 4. Breathing air, arterial saturation at rest was 93% and fell by 7% during exercise. Breathing 60% oxygen, resting saturation was 98% and there was no fall during exercise. 5. Breathing oxygen, ventilation for a given work load was reduced and exercise duration was increased...
Clin Sci (Lond) (1983) 65 (5): 521–526.
Published: 01 November 1983
... of submaximal work at V̇ o 2 = 1 litre/min rises significantly from 24.3 ±0.8 litres/min at age 64 years to 31.8 ± 1.8 litres/min at age 70 years; the latter value differs significantly from that of the young men (25.6 ± 0.9 litres/min). Similar changes are seen in the ventilation at 75 W and at V̇ co 2 = 1...
Clin Sci (Lond) (1983) 65 (1): 65–69.
Published: 01 July 1983
...P. M. A. Calverley; R. H. Robson; P. K. Wraith; L. F. Prescott; D. C. Flenley 1. To determine the mode of action of doxapram in man we have measured ventilation, oxygen uptake, CO 2 production, hypoxic and hypercapnic ventilatory responses in six healthy men before and during intravenous infusion...
Clin Sci (Lond) (1983) 65 (1): 57–63.
Published: 01 July 1983
... 1983 cardiopulmonary receptors coughing mental tasks monosynaptic spinal reflexes Mueller and Valsalva manoeuvres ventilation Clinical Science (1983) 65, 57-63 57 Depressive effect of coughing on spinal monosynaptic reflexes in conscious man D. MAILLARD, A. ROBY A N D J. C. WILLER...
Clin Sci (Lond) (1983) 64 (5): 487–495.
Published: 01 May 1983
... 1982 17 11 1982 © 1983 The Biochemical Society and the Medical Research Society 1983 carbon dioxide chronic airflow obstruction inspiratory muscles ventilation Clinical Science (1983) 64,487495 487 Role of impaired inspiratory muscle function in limiting the ventilatory response...
P. M. A. Calverley, D. J. Ewing, I. W. Campbell, P. K. Wraith, H. M. Brash, B. F. Clarke, D. C. Flenley
Clin Sci (Lond) (1982) 63 (1): 17–22.
Published: 01 July 1982
... cardiorespiratory arrest diabetes mellitus chemosensitivity transient hypoxia ventilation Clinical Science (1982) 63, 17-22 17 Preservation of the hypoxic drive to breathing in diabetic autonomic neuropathy P . M. A . C A L V E R L E Y , D . J . E W I N G , I . W. C A M P B E L L , P . K . W R A I T H , H...
Clin Sci (Lond) (1981) 61 (5): 599–603.
Published: 01 November 1981
... expiratory volume in 1 s (FEV 1.0 ) were within normal ranges and ventilatory responses to CO 2 in the range 5.32-5.99 kPa were not significantly different between patients and normal subjects. However, ventilation in the patients was significantly less than that in normal subjects when the alveolar partial...
Clin Sci (Lond) (1981) 61 (4): 429–439.
Published: 01 October 1981
...), but with various measures to enhance repeatability. 2. A high level of reproducibility was obtained in spite of the subjective nature of the assessment. Individual responses were described by the relationship between breathlessness and ventilation. The sensitivity of the method was demonstrated by the use...
Clin Sci (Lond) (1981) 60 (6): 667–674.
Published: 01 June 1981
... ventilation ( V E ), tidal volume ( V T ) is reduced with a fall in breath duration ( T t ) resulting from a decrease in inspiratory time ( T i ) with no change in expiratory time ( T e ). 4. The break point on the V T / T i relation is lowered. 12 12 1980 2 2 1981 © 1981 The Biochemical...
Clin Sci (Lond) (1980) 59 (2): 115–121.
Published: 01 August 1980
...H. Clarke; S. Dhingra; N. R. Anthonisen 1. In 18 patients with acute myocardial infarction, we measured ventilation, frequency, inspiratory duration and the pressure at the mouth 0.1 s after the onset of inspiration against an occluded airway; mean inspiratory flow and the fraction of the breathing...
Clin Sci Mol Med (1978) 54 (1): 9–16.
Published: 01 January 1978
...J. W. Reed; M. Ablett; J. E. Cotes 1. The ventilation and cardiac frequency during progressive exercise and the respiratory responses to breathing carbon dioxide have been measured in 33 female patients with mitral stenosis and in 31 control subjects. Compared with the control subjects...
Clin Sci Mol Med (1977) 53 (1): 93–100.
Published: 01 July 1977
...R. A. Stockley; J. M. Bishop 1. Oxygen breath tests were performed in seven patients with thyrotoxicosis. The inspired air was replaced by oxygen without their knowledge for 20 s and the fall in ventilation was recorded. 2. Ventilation fell significantly in all the patients within 40 s. The mean...
Clin Sci Mol Med (1977) 52 (3): 269–275.
Published: 01 March 1977
...J. R. A. Rigg; E. M. Inman; N. A. Saunders; S. R. Leeder; N. L. Jones 1. The effect of mental arithmetic tasks on ventilation, breathing pattern, oxygen intake and carbon dioxide output was studied during air breathing and carbon dioxide rebreathing in healthy subjects. 2. Ventilation and breathing...
Clin Sci Mol Med (1976) 50 (5): 367–373.
Published: 01 May 1976
... maximum hyperventilation in response to their acidosis, or perhaps their submaximal hypercapnia presaged imminent failure of the hyperventilatory response. 15 10 1975 © 1976 The Biochemical Society and the Medical Research Society 1976 acidaemia acidosis respiration ventilation...
Clin Sci Mol Med (1976) 50 (2): 109–114.
Published: 01 February 1976
...R. A. Stockley; K. D. Lee 1. Oxygen breath tests were performed in nine patients with diffuse pulmonary infiltration whose resting arterial P o 2 ( P a,o 2 ) ranged from 8·9 kPa to 11·8 kPa. The inspired air was suddenly replaced with oxygen for 30 s and the percentage fall in ventilation over...
Clin Sci Mol Med (1975) 48 (3): 235–238.
Published: 01 March 1975
... identical twins ventilation Clinical Science and Molecular Medicine (1975) 48, 235-238. SHORT COMMUNICATION Maximal oxygen uptake, lung volume and ventilatory response to carbon dioxide and hypoxia in a pair of identical twin athletes A. G. LEITCH, L. CLANCY AND D. C. FLENLEY Department of Medicine...
Clin Sci Mol Med (1974) 46 (4): 539–549.
Published: 01 April 1974
.... The inverse relation between arterial CO 2 tension and hydrogen ion activity suggests that during metabolic acidosis, alveolar ventilation increases in direct proportion to the increased blood hydrogen ion activity. 8 11 1973 © 1974 The Biochemical Society and the Medical Research Society 1974...
Clin Sci Mol Med (1974) 46 (3): 347–356.
Published: 01 March 1974
... varied considerably from patient to patient, but in each case the rate of rise was effectively linear with time. The resulting fall in ventilation, measured over 15 s periods, was compared with the P a,o 2 achieved. 3. In most patients the P a,o 2 did not reach hyperoxic levels. The total contribution...
Clin Sci Mol Med (1974) 46 (2): 191–206.
Published: 01 February 1974
...S. G. Spiro; E. Juniper; P. Bowman; R. H. T. Edwards 1. A progressive exercise test was performed on forty-four male and twenty-nine female healthy Europeans, aged between 20 and 64 years. Values for cardiac frequency (fH) and ventilation (V̇) were interpolated to standard (submaximal) oxygen...
Clin Sci Mol Med (1974) 46 (1): 113–123.
Published: 01 January 1974
... co 2 [H + ] metabolic acidosis metabolic alkalosis ventilation Clinical Science and Molecular Medicine (1974) 46, 113-123. THE RELATIONSHIP BETWEEN ARTERIAL Pco, A N D HYDROGEN ION CONCENTRATION IN CHRONIC METABOLIC ACIDOSIS A N D ALKALOSIS J. M. BONE, J. COWIE, A N N E T . LAMBIE AND J. S...
Clin Sci Mol Med (1973) 45 (1): 99–105.
Published: 01 July 1973
... and low arterial oxygen saturation at rest in air. ventilation exercise hypoxia congenital heart disease © 1973 The Biochemical Society and the Medical Research Society 1973 5 2 1973 Clinical Science and Molecular Medicine (1973) 45,99-105. THE VENTILATORY RESPONSE TO HYPOXIA D U R...
Clin Sci (1972) 43 (6): 861–867.
Published: 01 December 1972
...A. S. Rebuck; N. L. Jones; E. J. M. Campbell 1. Changes in ventilation during progressive exercise were measured in eleven normal subjects. Ventilatory response to carbon dioxide at rest was measured in the same subjects using a rebreathing method. 2. The range of ventilatory response to exercise...