... rabbit kidney perfused in the presence of indomethacin (10 μmol/l) and preconstricted with noradrenaline (7.2 nmol/min). 2. Under control conditions, bolus administrations of acetylcholine (10 μmol/l), an NO-dependent renal vasodilator, verapamil (0.1 mmol/l), an NO-independent renal vasodilator...

... secretion verapamil Clinical Science (1993) 84, 11-19 (Printed in Great Britain) Stimulatory action of parathyroid hormone on renin secretion lfn vitro: a study using isolated rat kidney, isolated rabbit glomeruli and superfused dispersed rat juxtaglomerular cells Christian SAUSSINE, C. JUDES, T...

... resuscitability after administration of calcium-entry blockers during cardiac arrest is incomplete. We therefore compared the effects of verapamil (0.05 mg/kg) and diltiazem (0.075 mg/kg) with those of saline placebo in an established porcine model of cardiac arrest and cardiopulmonary resuscitation. 2. After...

... secondary to the elevated blood pressure. 2. Indices of systemic calcium metabolism were followed prospectively during 6 months' treatment with either propranolol, bendroflumethiazide or verapamil in 35 patients with essential hypertension. Multivariate statistical methods were employed to study the effects...

...S. M. Pomfret; C. R. W. Beasley; V. Challenor; S. T. Holgate 1. The efficacy of verapamil alone, or in combination with digoxin, was compared with digoxin alone in eight patients with chronic atrial fibrillation in this double-blind placebo-controlled study. 2. After 2 weeks on each treatment...

...A. R. Douglas; J. C. Moore-Gillon; J. W. S. Sheldon; I. R. Cameron 1. Polycythaemia occurs in man secondary to chronic hypoxaemia, and may lead to morbidity from hyperviscosity of the blood. Hypoxaemic rats develop similar changes. We have investigated the effect of the calcium antagonist verapamil...

...Wann-Chu Huang 1. The effects of verapamil infusion alone and superimposed with captopril on arterial pressure and bilateral renal function were evaluated in 21 two-kidney, one-clip Goldblatt hypertensive rats and in 13 control rats. 2. Verapamil significantly decreased arterial pressure of both...

...N. Schoenfeld; J. Aelion; Y. Beigel; O. Epstein; A. Atsmon 1. Treatment of monolayers of chick embryo hepatocytes with the calcium channel blocking drugs nifedipine and verapamil resulted in a decrease in the activity of uroporphyrinogen decarboxylase, an increase in the activity of δ...

...C. H. C. Twort; J. E. Neild; I. R. Cameron 1. Two groups of eight normal subjects were investigated in separate studies to demonstrate the effects of changes in end-tidal P co 2 , and of pretreatment with the calcium antagonist drug verapamil, on bronchoconstriction provoked by voluntary...

...H. H. Gray; L. Poston; V. E. Johnson; P. J. Hilton 1. Sodium efflux rate constants and intracellular sodium were measured in leucocytes from healthy volunteers in the presence and absence of the calcium antagonist verapamil hydrochloride. 2. Verapamil stimulated sodium pump activity and this effect...

...B. F. Robinson; R. J. W. Phillips 1. The effect of a small increase in local plasma calcium concentration on the responsiveness of the forearm resistance vessels to verapamil has been examined in normal subjects, by using a plethysmographic method with infusion of calcium and other agents...

...Fritz R. Bühler; U. Lennart Hulthén; Wolfgang Kiowski; Peter Bolli 1. The calcium slow channel inhibitor verapamil was administered as monotherapy (240-270 mg; mean 427 mg/day) on the average for 93 days to 43 patients with essential hypertension; 11 with low, 24 with normal and eight with high...