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Keyword: vitamin D
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Clin Sci (Lond) (2013) 124 (9): 553-566.
Published: 21 January 2013
... evaluating the two principal approaches to renin inhibition, namely direct renin inhibition with aliskiren and inhibition of the (pro)renin receptor. Moreover, the possibilities of renin inhibition and nephroprotection by interventions primarily aiming at non-RAAS targets, such as vitamin D, urocortins or...
Clin Sci (Lond) (2011) 120 (3): 91-97.
Published: 14 October 2010
... circulating factors, like vitamin D, PTH (parathyroid hormone) and FGF23 (fibroblast growth factor 23), are essential for regulation of physiological phosphate balance. Dysregulation of these factors, either alone or in combination, can induce phosphorus imbalance. Recent studies have shown that suppression...
Clin Sci (Lond) (2010) 119 (3): 111-121.
Published: 28 April 2010
..., parathyroid hormone or vitamin D, a better understanding of the mechanisms of abnormal tissue calcification may lead to development of new therapeutic agents, which could reduce VC and improve cardiovascular outcome in CKD patients. The present review summarizes the following aspects: (i) the...
Clin Sci (Lond) (2009) 116 (12): 871.
Published: 14 May 2009
...William B. Grant Correspondence: Mr William B. Grant ( wbgrant@infionline.net ). 30 10 2008 10 12 2008 10 12 2008 © The Authors Journal compilation © 2009 Biochemical Society 2009 pre-eclampsia UV light vascular endothelial growth factor (VEGF) vitamin D...
Clin Sci (Lond) (2000) 98 (2): 217-240.
Published: 31 January 2000
... become possible to describe their precise mechanism of action. This review focuses not only on the steroid hormones (oestrogens, corticosteroids, androgens and progesterone), but also on related hormones (vitamin D, thyroid hormone and the retinoids), all of which act via structurally homologous nuclear...
Clin Sci (Lond) (1993) 84 (1): 51-54.
Published: 01 January 1993
...Sandro Giannini; Martino Nobile; Rocco Castrignano; Tecla Pati; Andrea Tasca; Giorgio Villi; Federico Pellegrini; Angela D'Angelo 1. Vitamin D seems to play an essential role in the pathogenesis of idiopathic hypercalciuria at least in part via intestinal hyperabsorption of calcium. Hyper...
Clin Sci (Lond) (1990) 78 (3): 295-302.
Published: 01 March 1990
...-mediated bone buffering. 6 9 1989 7 11 1989 © 1990 The Biochemical Society and the Medical Research Society 1990 acetazolamide acid-base balance acidosis calcium metabolism haemodialysis uraemia vitamin D Clinical Science (1990) 78,295-302 295 Severe metabolic acidosis and...
Clin Sci (Lond) (1989) 77 (2): 171-176.
Published: 01 August 1989
... associated with various metabolic myopathies, including osteomalacia. 2. The maximum voluntary contraction (MVC) of the dominant quadriceps and plasma 25-hydroxycholecalciferol [25-(OH)D] were measured in male alcoholics and control subjects to determine whether vitamin D deficiency contributed to proximal...
Clin Sci (Lond) (1987) 73 (6): 659-664.
Published: 01 December 1987
... by an increased excretion of vitamin D-derived inactivation products in the faeces. 4. Enhanced hepatic inactivation of 25-hydroxyvitamin D may be important in the development of vitamin D deficiency in primary hyperparathyroidism. 18 5 1987 15 6 1987 © 1970 The Biochemical Society...
Clin Sci (Lond) (1987) 73 (5): 541-546.
Published: 01 November 1987
..., height, weight and sex in a multi-factorial analysis. 4. Only in males did MVC correlate with height and weight. Asian women were more obese than any other group, and showed an increase in body mass index with age. 5. Twenty-two per cent of Asian subjects had marked vitamin D deficiency (plasma 25...
Clin Sci (Lond) (1985) 69 (3): 265-271.
Published: 01 September 1985
... receiving ethinyloestradiol showed a marked increase in plasma 1,25-dihydroxyvitamin D (1,25-(OH) 2 D) concentration but this was explicable entirely in terms of increased plasma levels of vitamin D binding protein. There was no change in the free plasma level of 1,25(OH) 2 D. Patients treated with...
Clin Sci (Lond) (1985) 68 (1): 97-100.
Published: 01 January 1985
...U. Gafter; S. Edelstein; J. Levi 1. The effect of bicarbonate (NaHCO 3 ) feeding on intestinal absorption of calcium and phosphorus and vitamin D metabolism was investigated. Gut sac uptake of 45 Ca and [ 32 P]phosphate in vitro , as well as the plasma level of vitamin D metabolites, was determined...
Clin Sci (Lond) (1984) 67 (6): 591-599.
Published: 01 December 1984
... with plasma vitamin D metabolite levels and kinetic indices related to the balance of fluxes of calcium between plasma and the rapidly exchangeable calcium pools of bone. 2. Compared with adult man, results obtained before treatment started showed lower indices of gastrointestinal calcium absorption...
Clin Sci (Lond) (1982) 63 (5): 461-472.
Published: 01 November 1982
... yield the same plasma 25-(OH)D 3 concentration as u.v. irradiation and was 0.0024 ± 0.0018 nmol/mJ. 8. Rates of cholecalciferol synthesis calculated from these data suggest that many of the population of England receive insufficient u.v. irradiation to maintain vitamin D status throughout the year...
Clin Sci (Lond) (1981) 61 (4): 471-476.
Published: 01 October 1981
...U. Trechsel; C. M. Taylor; J. A. Eisman; J.-P. Bonjour; H. Fleisch 1. Protein-binding assays have been used to measure plasma 1,25-dihydroxy-vitamin D [1,25-(OH) 2 D] as well as 25-hydroxy-vitamin D [25-(OH)D] in rats given 10 mg of phosphorus (P) day −1 kg −1 as ethane-1-hydroxy-1,1-diphosphonate...
Clin Sci (Lond) (1981) 60 (2): 241-243.
Published: 01 February 1981
...Juliet E. Compston; Anne L. Merrett; F. G. Hammett; P. Magill 1. The uptake of either orally administered [ 3 H]vitamin D 3 or 25-[ 3 H]hydroxy-vitamin D 3 into the chylomicron fraction of plasma was studied in 12 healthy male subjects. 2. The amount of [ 3 H]vitamin D 3 in the chylomicron fraction...
Clin Sci (Lond) (1980) 58 (3): 235-242.
Published: 01 March 1980
... for up to 15 min total exposure. This contrasted with the prolonged increase in plasma 25-(OH)D continuing over several weeks in response to whole-body ultraviolet irradiation. This may indicate that cutaneous synthesis of vitamin D is rapid but limited, and that the considerable rise in plasma 25-(OH...
Clin Sci (Lond) (1979) 57 (3): 257-263.
Published: 01 September 1979
...Jennifer J. Pointon; M. J. O. Francis; R. Smith 1. Weanling rabbits were made rachitic either by a vitamin D-deficient diet or by parenteral administration of ethane 1-hydroxy-1,1-diphosphonate (EHDP) in amounts sufficient in other species to block the formation of 1,25-dihydroxycholecalciferol...
Clin Sci Mol Med (1978) 55 (2): 195-198.
Published: 01 August 1978
... and the Medical Research Society 1978 cadmium intestinal absorption vitamin D Clinical Science and Molecular Medicine (1978) 55,195-198 Intestinal absorption and tissue retention of cadmium and calcium in normal adult rats and rats given an active metabolite of vitamin D (1,25...
Clin Sci Mol Med (1975) 48 (3): 177-186.
Published: 01 March 1975
...R. G. G. Russell; R. Smith; C. Preston; R. J. Walton; C. G. Woods; R. G. Henderson; A. W. Norman 1. 1,25-Dihydroxycholecalciferol (1,25-(OH) 2 -D 3 ) was given at a dose of 5.0 nmol (2.1 μg) daily by mouth for 4–12 days to three patients with hypophosphataemic (type I), vitamin D-resistant rickets...
Clin Sci Mol Med (1974) 47 (1): 23-42.
Published: 01 July 1974
... extent of the calcification front in that osteoid lamella lying next to calcified bone. 3. Administration of calcium compounds orally produced an increase of punctate calcification within the osteoid, but there was no change in the extent of the calcification front. 4. Administration of vitamin D...
Clin Sci Mol Med (1974) 46 (4): 433-448.
Published: 01 April 1974
...-HCC. 4. Treatment with phenobarbitone enhanced the excretion of metabolites of radioactive vitamin D 3 in bile. These metabolites were largely water-soluble conjugates of peaks IV, V and VI, which included glucuronides. Peak IV in bile was not identical with 25-HCC. 5. Prolonged treatment with...
Clin Sci Mol Med (1973) 44 (1): 33-41.
Published: 01 January 1973
...PH. J. Bordier; S. Tun Chot; J. B. Eastwood; A. Fournier; H. E. De Wardener 1. Iliac bone biopsies were obtained from nine patients 3 months to 6 years after bilateral nephrectomy. 2. In eight of the nine patients no histological evidence of vitamin D abnormality was seen in the bones after...
Clin Sci (1972) 43 (3): 413-431.
Published: 01 September 1972
...E. Barbara Mawer; Joan Backhouse; Carlene A. Holman; G. A. Lumb; S. W. Stanbury 1. The distribution of vitamin D and its metabolites in human tissues has been studied by the combined use of radioactive cholecalciferol and biological assays of antiricketic activity in tissue extracts. 2. Injected...
Clin Sci (1972) 42 (4): 515-522.
Published: 01 April 1972
...W. H. Taylor 1. Of 104 patients with renal calculi, 42% gave a history of previous self-medication with multivitamin preparations containing vitamin D, compared with 37% of a control group of fifty-one patients without renal calculi. This difference is not significant. 2. The mean supplemental...
Clin Sci (1972) 42 (2): 235-241.
Published: 01 February 1972
... of osteoporosis. 4 11 1971 © 1972 The Biochemical Society and the Medical Research Society 1972 parathyroid hormone calcitonin bone calcium osteoporosis vitamin D Clinical Science (1972) 42,235-241. SHORT COMM UNICA TI0 N CALCIUM SHIFT INTO BONE: A CALCITONIN- RESISTANT...
Clin Sci (1972) 42 (1): 113-116.
Published: 01 January 1972
... infant with associated kwashiorkor and a child with late onset juvenile rickets. 2. Five children, reinvestigated after 6 weeks of vitamin D treatment, showed highly significant falls in P.T.H. concentration, confirming the functional nature of the secondary hyperparathyroidism. The activity of plasma...