...Roy Taylor; Alison C. Barnes; Kieren G. Hollingsworth; Keaton M. Irvine; Alexandra S. Solovyova; Lucy Clark; Tara Kelly; Carmen Martin-Ruiz; Davide Romeres; Albert Koulman; Claire M. Meek; Benjamin Jenkins; Claudio Cobelli; Rury R. Holman Weight loss in overweight or obese individuals with Type 2...

... protocol led to ∼ 20% weight loss, normalized metabolic parameters and was associated with reductions in indices of glomerular and proximal tubular injury. The transcriptomic response to DMT was dominated by changes in fenofibrate- and peroxisome proliferator-activated receptor-α (PPARα)-governed...

..., is a population measure and not a rigid personal guide. Weight loss is considered de rigueur for treating obese diabetic individuals, but it is not usually considered for those deemed to have a normal BMI. Given the new evidence that early T2DM can be reversed to normal glucose tolerance by substantial weight...

...Priya Sumithran; Joseph Proietto Although weight loss can usually be achieved by restricting food intake, the majority of dieters regain weight over the long-term. In the hypothalamus, hormonal signals from the gastrointestinal tract, adipose tissue and other peripheral sites are integrated...

... restriction is the most commonly used weight loss strategy. In the present study, we examined the effect of weight loss on HDL-apoA-II kinetics in men with the MetS at the start and end of a 16-week intervention trial of a hypocaloric low-fat diet ( n =20) compared with a weight maintenance diet ( n =15...

...% respectively, were observed ( P <0.05 for all of the forms). Total plasma adiponectin was increased by 36% with borderline significance ( P =0.08). No correlations between changes in adiponectin complexes and changes in indices of insulin sensitivity were observed. In conclusion, diet-induced weight loss...

... to weight loss. Eighteen obese subjects were studied during diet-induced weight loss. β-Adrenergic receptor mRNA levels were quantified by reverse transcription-PCR–HPLC. β-Adrenergic receptor protein concentrations were measured by Western blotting using fluorescence laser scanning for detection. Subjects...

... of energy homoeostasis would increase appetite and thus, by consequence, offset the weight loss traditionally experienced at high altitude. Sixteen moderately active Caucasians (11 males and five females) with a sea-level V ̇ O 2 max (maximal oxygen uptake) of 3.24±0.51 litres/min (45±8 ml·kg −1...

... as central to the development of atherogenesis. As part of a study to investigate responses to weight loss, we have assessed the effects on GSH status of a decrease in body mass of 5%, either after 6 days of complete starvation or 11 days of a very low calorie diet (2.55MJ/day). There were significant...

... Society © 2001 2001 hypocretin intestinal inflammation melanin-concentrating hormone neuropeptide Y weight loss 221Clinical Science (2001) 100, 221 229 (Printed in Great Britain) Role of hypothalamic neuropeptide Y and orexigenic peptides in anorexia associated with experimental colitis...

...) spectroscopy, reflect elevated whole-body glucose turnover and gluconeogenesis from alanine. Patients with advanced non-small-cell lung cancer without liver metastases ( n = 24; weight loss 0–24%) and healthy control subjects ( n = 13) were studied after an overnight fast. 31 P MR spectra of the liver in vivo...

... reflect the capacity for protein synthesis. 2. Patients with weight loss due to cancer ( n = 6) were compared with metabolically healthy patients before elective surgery ( n = 7). Alkali-soluble protein/DNA and RNA/DNA ratios in the weight loss group were 248 (14) g/g and 1.3 (0.1) g/g respectively...

... to the development of muscle rigidity in the untreated state. 3. In Parkinson's disease, even in optimally treated patients, resting energy expenditure is raised and this may contribute to the weight loss seen in this disease. Severe muscle rigidity occurring during untreated periods results in a further increase...

...J. E. Compston; M. A. Laskey; P. I. Croucher; A. Coxon; S. Kreitzman 1. Total body areal bone mineral density was measured by dual-energy X-ray absorptiometry in eight women before and 10 weeks after a very-low-calorie diet [405 kcal (1701 kJ)/day]. 2. The mean weight loss of 15.6 kg...

... in an increase in deep muscle temperature and a decrease in isometric endurance. 5. When muscle temperature was stabilized before and after weight loss by immersing the forearm in water at 37°C, a reduction in body fat no longer influenced endurance. 6. It was concluded that the change in isometric endurance...