Celebrating 125 years of the Synapse

2022 marks 125 years since Sir Charles Scott Sherrington’s pioneering work on the ‘synapse’, and 90 years since he was awarded the Nobel Prize in Physiology or Medicine, jointly with Edgar Douglas Adrian, "for their discoveries regarding the functions of neurons." Critical to the scope and creation of Neuronal Signaling, the journal reflects on the past 125 years of studying the synapse and how Sherrington’s discoveries have shaped today’s research through this special themed collection.

This Neuronal Signaling themed collection aims to share articles investigating and celebrating the synapse, with a focus on its role in the context of neuronal signaling and networks. Topics covered include synaptic protein turnover in the healthy and aging brain, high-resolution imaging techniques to visualise the synapse, thalamic circuitry, plus major historical developments in synaptic research and how the word ‘synapse’ came about.

We would like to thank all the authors for their excellent contributions, and we hope you enjoy reading this special collection.