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Coronavirus

On 31 January 2020, the Biochemical Society and its publisher, Portland Press, committed to the rapid and open sharing of research data and findings relevant to the coronavirus (2019-nCoV) global pandemic, with the intention of ensuring research findings and data relevant to this outbreak were shared rapidly and openly to help save lives.

Since then, our published articles and new papers relevant to this virus have been available via open access on publication. You can access these via the links below and authors are also encouraged to post submitted versions of articles as preprints.

Note: this collection is frequently updated as new research becomes available.

Efficient overexpression and purification of severe acute respiratory syndrome coronavirus 2 nucleocapsid proteins in Escherichia coli

Emma L. Brudenell; Manoj B. Pohare; Domen Zafred; Janine Phipps; Hailey R. Hornsby; John F. Darby; Junxiao Dai; Ellen Liggett; Kathleen M. Cain; Perdita E. Barran; Thushan I. de Silva; Jon R. Sayers

https://doi.org/10.1042/BCJ20240019

The art of hijacking: how Nsp1 impacts host gene expression during coronaviral infections

Evangelos D. Karousis

https://doi.org/10.1042/BST20231119

Aminoacyl-tRNA synthetase interactions in SARS-CoV-2 infection

Debjit Khan; Paul L. Fox

https://doi.org/10.1042/BST20230527

Alpha-1-antitrypsin antagonizes COVID-19: a review of the epidemiology, molecular mechanisms, and clinical evidence

Xiyuan Bai; Tony Schountz; Ashley M. Buckle; Janet L. Talbert; Robert A. Sandhaus; Edward D. Chan

https://doi.org/10.1042/BST20230078

Mechanisms of impairment of interferon production by SARS-CoV-2

Huy-Dung Hoang; Parisa Naeli; Tommy Alain; Seyed Mehdi Jafarnejad

https://doi.org/10.1042/BST20221037

Humoral immunity and B-cell memory in response to SARS-CoV-2 infection and vaccination

Holly A. Fryer; Gemma E. Hartley; Emily S.J. Edwards; Robyn E. O'Hehir; Menno C. van Zelm

https://doi.org/10.1042/BST20220415

Vascular dysfunction in COVID-19 patients: update on SARS-CoV-2 infection of endothelial cells and the role of long non-coding RNAs

Jaroslav Pelisek; Benedikt Reutersberg; Urs F Greber; Alexander Zimmermann

https://doi.org/10.1042/CS20220235

Therapeutic use of calpeptin in COVID-19 infection

Jameel Inal; Ainura Paizuldaeva; Esmeralda Terziu

https://doi.org/10.1042/CS20220638

Therapeutic potential of metal ions for COVID-19: insights from the papain-like protease of SARS-CoV-2

Cameron Lee Shetler; Juliana C. Ferreira; Thyago H. S. Cardoso; Edson M.A. Silva; Nitin K. Saksena; Wael M. Rabeh

https://doi.org/10.1042/BCJ20220380

The potential role of ischaemia–reperfusion injury in chronic, relapsing diseases such as rheumatoid arthritis, Long COVID, and ME/CFS: evidence, mechanisms, and therapeutic implications

Douglas B. Kell; Etheresia Pretorius

https://doi.org/10.1042/BCJ20220154

Development of a colorimetric assay for the detection of SARS-CoV-2 3CLpro activity

Gavin D. Garland; Robert F. Harvey; Thomas E. Mulroney; Mie Monti; Stewart Fuller; Richard Haigh; Pehuén Pereyra Gerber; Michael R. Barer; Nicholas J. Matheson; Anne E. Willis

https://doi.org/10.1042/BCJ20220105

SARS-CoV-2 spike protein causes cardiovascular disease independent of viral infection

John D. Imig

https://doi.org/10.1042/CS20220028

Programmed cell death: the pathways to severe COVID-19?

Stefanie M. Bader; James P. Cooney; Marc Pellegrini; Marcel Doerflinger

https://doi.org/10.1042/BCJ20210602

A central role for amyloid fibrin microclots in long COVID/PASC: origins and therapeutic implications

Douglas B. Kell; Gert Jacobus Laubscher; Etheresia Pretorius

https://doi.org/10.1042/BCJ20220016

Erythrocytes increase endogenous sphingosine 1-phosphate levels as an adaptive response to SARS-CoV-2 infection

Martin Sebastian Winkler; Ralf Alexander Claus; Mareike Schilder; Stefan Pöhlmann; Sina M. Coldewey; Julian Grundmann; Torben Fricke; Onnen Moerer; Konrad Meissner; Michael Bauer; Heike Hofmann-Winkler; Markus H. Gräler

https://doi.org/10.1042/CS20210666

The SARS-CoV-2 Spike protein disrupts human cardiac pericytes function through CD147 receptor-mediated signalling: a potential non-infective mechanism of COVID-19 microvascular disease

Elisa Avolio; Michele Carrabba; Rachel Milligan; Maia Kavanagh Williamson; Antonio P. Beltrami; Kapil Gupta; Karen T. Elvers; Monica Gamez; Rebecca R. Foster; Kathleen Gillespie; Fergus Hamilton; David Arnold; Imre Berger; Andrew D. Davidson; Darryl Hill; Massimo Caputo; Paolo Madeddu

https://doi.org/10.1042/CS20210735

Computational and in vitro experimental analyses of the anti-COVID-19 potential of Mortaparib and Mortaparib Plus

Vipul Kumar; Anissa Nofita Sari; Hazna Noor Meidinna; Jaspreet Kaur Dhanjal; Chandru Subramani; Brohmomoy Basu; Sunil C. Kaul; Sudhanshu Vrati; Durai Sundar; Renu Wadhwa

https://doi.org/10.1042/BSR20212156

Diversity of ACE2 and its interaction with SARS-CoV-2 receptor binding domain

Jessie Low-Gan; Ruiqi Huang; Abigail Kelley; Gabrielle Warner Jenkins; Duncan McGregor; Vaughn V. Smider

https://doi.org/10.1042/BCJ20200908

How dendritic cells sense and respond to viral infections

Laura Marongiu; Mihai Valache; Fabio A. Facchini; Francesca Granucci

https://doi.org/10.1042/CS20210577

Targeting intra-viral conserved nucleocapsid (N) proteins as novel vaccines against SARS-CoVs

Min Thura; Joel Xuan En Sng; Koon Hwee Ang; Jie Li; Abhishek Gupta; Jimmy Ming Hong; Cheng William Hong; Qi Zeng

https://doi.org/10.1042/BSR20211491