Microorganisms are in constant competition for growth niches and environmental resources. In Gram-negative bacteria, contact-dependent growth inhibition (CDI) systems link the fate of one cell with its immediate neighbor through touch-dependent, receptor-mediated toxin delivery. Though discovered for their ability to confer a competitive growth advantage, CDI systems also play significant roles in intersibling cooperation, promoting both auto-aggregation and biofilm formation. In this review, we detail the mechanisms of CDI toxin delivery and consider how toxin exchange between isogenic sibling cells could regulate gene expression.
Can't you hear me knocking: contact-dependent competition and cooperation in bacteria
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Daniel Walker, Allison M. Jones, David A. Low, Christopher S. Hayes; Can't you hear me knocking: contact-dependent competition and cooperation in bacteria. Emerg Top Life Sci 21 April 2017; 1 (1): 75–83. doi: https://doi.org/10.1042/ETLS20160019
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