What are all these hundreds of different bacterial species doing in and on us? What interactions occur between the host and the microbes, and between the microbes themselves? By studying proteins, metaproteomics tries to find preliminary answers to these questions. There is daunting complexity around this; in fact, many of these proteins have never been studied before. This article is an introduction to the field of metaproteomics in the context of the human microbiome. It summarizes where we are and what we have learnt so far. The focus will be on faecal proteomics as most metaproteomics research has been conducted on that sample type. Metaproteomics has made major advances in the past decade, but new sample preparation strategies, improved mass spectrometric analysis and, most importantly, data analysis and interpretation have the potential to pave the way for large-cohort metaproteomics.
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November 2017
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A representation of the intestinal microflora. There is growing interest in the role of the gut microbiome in human health and disease, and this issue of Emerging Topics in Life Sciences includes reviews that focus on microbiome–host interactions and host health (Basson and Wijeyesekera, pages 325–332), the role of the gut bacterium Bifidobacterium in modulating immune-linked diseases (O'Neill et al., pages 333–349) and the gut virome in humans (Ogilvie and Jones, pages 351–362).
Review Article|
November 30 2017
Proteomics and the human microbiome: where we are today and where we would like to be Available to Purchase
Carolin Adriane Kolmeder
Carolin Adriane Kolmeder
*
1University of Helsinki, Helsinki, Finland
Correspondence: Carolin Adriane Kolmeder ([email protected])
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Publisher: Portland Press Ltd
Received:
August 07 2017
Revision Received:
October 20 2017
Accepted:
November 06 2017
Online ISSN: 2397-8562
Print ISSN: 2397-8554
© 2017 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society and the Royal Society of Biology
2017
Emerg Top Life Sci (2017) 1 (4): 401–409.
Article history
Received:
August 07 2017
Revision Received:
October 20 2017
Accepted:
November 06 2017
Citation
Julian R. Marchesi, Carolin Adriane Kolmeder; Proteomics and the human microbiome: where we are today and where we would like to be. Emerg Top Life Sci 30 November 2017; 1 (4): 401–409. doi: https://doi.org/10.1042/ETLS20170051
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