Parasitic nematodes express a large number of distinct nicotinic acetylcholine receptors and these in turn are the targets of many classes of anthelmintic drug. This complexity poses many challenges to the field, including sorting the exact subunit composition of each of the receptor subtypes and how much they vary between species. It is clear that the model organism Caenorhabditis elegans does not recapitulate the complexity of nicotinic pharmacology of many parasite species and data using this system may be misleading when applied to them. The number of different receptors may allow nematodes some plasticity which they can exploit to evolve resistance to a specific cholinergic drug; however, this may mean that combinations of cholinergic agents may be effective at sustainably controlling them. Resistance may involve the expression of truncated receptor subunits that affect the expression levels of the receptors via mechanisms that remain to be deciphered.
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Trypanosoma brucei, the causative agent of African sleeping sickness. Among the parasitology topics covered in this issue are perspectives on various aspects of trypanosome biology: Kemmerling et al. (pages 573–577) look at the immune response against Trypanosoma cruzi in the human placenta, while Maya et al. (pages 579–584) discuss therapeutic strategies in chronic Chagas cardiomyopathy, which is caused by T. cruzi. In addition, McCulloch et al. (pages 585–592) and Ooi and Rudenko (pages 593–600) explore antigenic variation in trypanosomes. Image credit: Kateryna Kon (Shutterstock ID: 520410646).
The interactions of anthelmintic drugs with nicotinic receptors in parasitic nematodes
Roberto Docampo, Adrian J. Wolstenholme, Cedric Neveu; The interactions of anthelmintic drugs with nicotinic receptors in parasitic nematodes. Emerg Top Life Sci 22 December 2017; 1 (6): 667–673. doi: https://doi.org/10.1042/ETLS20170096
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