Microbial cell factories are extensively used for the biosynthesis of value-added chemicals, biopharmaceuticals, and biofuels. Microbial biosynthesis is also realistic for the production of heterologous molecules including complex natural products of plant and microbial origin. Glycosylation is a well-known post-modification method to engineer sugar-functionalized natural products. It is of particular interest to chemical biologists to increase chemical diversity of molecules. Employing the state-of-the-art systems and synthetic biology tools, a range of small to complex glycosylated natural products have been produced from microbes using a simple and sustainable fermentation approach. In this context, this review covers recent notable metabolic engineering approaches used for the biosynthesis of glycosylated plant and microbial polyketides in different microorganisms. This review article is broadly divided into two major parts. The first part is focused on the biosynthesis of glycosylated plant polyketides in prokaryotes and yeast cells, while the second part is focused on the generation of glycosylated microbial polyketides in actinomycetes.
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October 2018
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Review Article|
August 06 2018
Metabolic engineering of glycosylated polyketide biosynthesis
Ramesh Prasad Pandey
;
Ramesh Prasad Pandey
1
Department of BT-Convergent Pharmaceutical Engineering, Sun Moon University, 70 Sunmoon-ro 221, Tangjeong-myeon, Asan-si, Chungnam 31460, Republic of Korea2
Department of Life Science and Biochemical Engineering, Sun Moon University, 70 Sunmoon-ro 221, Tangjeong-myeon, Asan-si, Chungnam 31460, Republic of Korea
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Prakash Parajuli
;
Prakash Parajuli
2
Department of Life Science and Biochemical Engineering, Sun Moon University, 70 Sunmoon-ro 221, Tangjeong-myeon, Asan-si, Chungnam 31460, Republic of Korea
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Jae Kyung Sohng
1
Department of BT-Convergent Pharmaceutical Engineering, Sun Moon University, 70 Sunmoon-ro 221, Tangjeong-myeon, Asan-si, Chungnam 31460, Republic of Korea2
Department of Life Science and Biochemical Engineering, Sun Moon University, 70 Sunmoon-ro 221, Tangjeong-myeon, Asan-si, Chungnam 31460, Republic of Korea
Correspondence: Jae Kyung Sohng (sohng@sunmoon.ac.kr)
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Emerg Top Life Sci (2018) 2 (3): 389-403.
Article history
Received:
April 10 2018
Revision Received:
May 28 2018
Accepted:
May 29 2018
Citation
Mattheos A.G. Koffas, Robert J. Linhardt, Ramesh Prasad Pandey, Prakash Parajuli, Jae Kyung Sohng; Metabolic engineering of glycosylated polyketide biosynthesis. Emerg Top Life Sci 26 October 2018; 2 (3): 389–403. doi: https://doi.org/10.1042/ETLS20180011
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