Living cells naturally maintain a variety of metabolic reactions via energy conversion mechanisms that are coupled to proton transfer across cell membranes, thereby producing energy-rich compounds. Until now, researchers have been unable to maintain continuous biochemical reactions in artificially engineered cells, mainly due to the lack of mechanisms that generate energy-rich resources, such as adenosine triphosphate (ATP) and reduced nicotinamide adenine dinucleotide (NADH). If these metabolic activities in artificial cells are to be sustained, reliable energy transduction strategies must be realized. In this perspective, this article discusses the development of an artificially engineered cell containing a sustainable energy conversion process.
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November 2019
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This issue of Emerging Topics in Life Sciences brings together a collection of perspectives and reviews discussing the exciting advances in synthetic biology. The cover image is an adaptation of a figure featured in the review ‘Physicochemical considerations for bottom-up synthetic biology’ by Śmigiel et al. It shows an artist's impression of a bottom-up constructed synthetic cell, representing the three basic processes of a living cell: cell fuelling (green), DNA processing (orange/red), and cell division (blue).
Perspective|
November 01 2019
Artificial cells containing sustainable energy conversion engines Available to Purchase
Kwanwoo Shin
Department of Chemistry and Institute of Biological Interfaces, Seoul 04107, Republic of Korea
Correspondence: Kwanwoo Shin ([email protected])
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Publisher: Portland Press Ltd
Received:
July 14 2019
Revision Received:
October 09 2019
Accepted:
October 10 2019
Online ISSN: 2397-8562
Print ISSN: 2397-8554
© 2019 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society and the Royal Society of Biology
2019
Emerg Top Life Sci (2019) 3 (5): 573–578.
Article history
Received:
July 14 2019
Revision Received:
October 09 2019
Accepted:
October 10 2019
Citation
Kwanwoo Shin; Artificial cells containing sustainable energy conversion engines. Emerg Top Life Sci 11 November 2019; 3 (5): 573–578. doi: https://doi.org/10.1042/ETLS20190103
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