Implants have long been used in the field of drug delivery as controlled release vehicles and are now being investigated as single-shot vaccine technologies. Implants have shown great promise, minimizing the need for multiple immunizations while stimulating potent immune responses with reduced doses of vaccine. Synchronous release of vaccine components from implants over an appropriate period of time is important in order to avoid issues including immune tolerance, sequestration or deletion. Traditionally, implants require surgical implantation and removal, which can be a barrier to their widespread use. Degradable and in situ implants are now being developed that can be administered using minimally invasive subcutaneous or intramuscular injection techniques. Injectable hydrogels remain the most commonly studied approach for sustained vaccine delivery due to their ease of administration and tunable degradation properties. Despite exciting advancements in the field of vaccine implants, few technologies have progressed to clinical trials. To increase the likelihood of clinical translation of vaccine implants, strategic testing of disease-relevant antigens in appropriate species is essential. In this review, the significance of vaccine implants and the different types of implants being developed to deliver vaccines are discussed.
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December 2020
Issue Editors
Terry Tetley;
Jorge Bernardino de la Serna;
Sonia Antoranz Contera
Jorge Bernardino de la Serna
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Cover Image
Cover Image
The cover image of this issue of Emerging Topics in Life Sciences: Biotechnology, Nanotechnology and Medicine, shows a cancerous human lung in the back and a gold nanoparticle in the front. It represents the main objective of the review by Guinart et al.; to give insight into the role that gold nanoparticles can have in the management of lung cancer.
Review Article|
November 24 2020
Vaccine implants: current status and recent advancements
Sharan Bobbala;
Sharan Bobbala
1Department of Biomedical Engineering, Northwestern University, Evanston, IL, U.S.A.
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Sarah Hook
2School of Pharmacy, University of Otago, Dunedin, New Zealand
Correspondence: Sarah Hook (sarah.hook@otago.ac.nz)
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Emerg Top Life Sci (2020) 4 (6): 601–612.
Article history
Received:
September 07 2020
Revision Received:
October 29 2020
Accepted:
November 05 2020
Citation
Sharan Bobbala, Sarah Hook; Vaccine implants: current status and recent advancements. Emerg Top Life Sci 17 December 2020; 4 (6): 601–612. doi: https://doi.org/10.1042/ETLS20200164
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