Untargeted metabolomics enables the identification of key changes to standard pathways, but also aids in revealing other important and possibly novel metabolites or pathways for further analysis. Much progress has been made in this field over the past decade and yet plant metabolomics seems to still be an emerging approach because of the high complexity of plant metabolites and the number one challenge of untargeted metabolomics, metabolite identification. This final and critical stage remains the focus of current research. The intention of this review is to give a brief current state of LC–MS based untargeted metabolomics approaches for plant specific samples and to review the emerging solutions in mass spectrometer hardware and computational tools that can help predict a compound's molecular structure to improve the identification rate.
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May 2021
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In recent years, an array of emerging technologies are propelling plant science in new directions and allowing for the integration of data across multiple scales. This special issue on Emerging Topics in Plant Science brings together reviews that spotlight a range of technologies that are changing how we ask questions and integrate those questions from the macromolecular to ecosystem scales.
Review Article|
March 11 2021
Mass spectrometry based untargeted metabolomics for plant systems biology
Sophie Alvarez
;
Proteomics and Metabolomics Facility, Nebraska Center for Biotechnology, University of Nebraska, Lincoln, NE 68588, USA
Correspondence: Sophie Alvarez ([email protected])
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Michael J. Naldrett
Michael J. Naldrett
Proteomics and Metabolomics Facility, Nebraska Center for Biotechnology, University of Nebraska, Lincoln, NE 68588, USA
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Publisher: Portland Press Ltd
Received:
November 24 2020
Revision Received:
February 04 2021
Accepted:
February 22 2021
Online ISSN: 2397-8562
Print ISSN: 2397-8554
© 2021 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society and the Royal Society of Biology
2021
Emerg Top Life Sci (2021) 5 (2): 189–201.
Article history
Received:
November 24 2020
Revision Received:
February 04 2021
Accepted:
February 22 2021
Citation
Joseph M. Jez, Christopher N. Topp, Sophie Alvarez, Michael J. Naldrett; Mass spectrometry based untargeted metabolomics for plant systems biology. Emerg Top Life Sci 21 May 2021; 5 (2): 189–201. doi: https://doi.org/10.1042/ETLS20200271
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