An illustration of nerve, muscle and DNA. It can be interpreted as a genetic mutation that causes neuromuscular disorders, or the wave of genetic-based therapies for neuromuscular disorders. The colourful dots represent unique individuals affected by rare diseases. For more details on the development of genome engineering in congenital muscular dystrophy, see the review by Kemaladewi et al. on pages 11–18.
The existence of coral reefs is threatened by climate change. This issue’s cover image shows part of a fringing reef on the north coast of Jamaica near Discovery Bay at Pear Tree Bottom. Photo taken on 10 August 2012 by Professor M.J.C. Crabbe.
This issue of Emerging Topics in Life Sciences was guest edited by Professor Waseem Qasim, NIHR Professor in Cell & Gene Therapy and Consultant in Paediatric Immunology/BMT at the Institute of Child Health & Great Ormond Street Hospital. The issue looks at the potential of ex-vivo edited cell therapies. Cover image courtesy of LuckyStep via Shutterstock.com.
Current whole-genome sequencing data requires a multitude of processing steps to account for technical noise and accurately identify genetic variation for downstream analyses, such as association testing with complex traits and diseases. In the latest issue of Emerging Topics in Life Sciences: Interpreting and Integrating Big Data in the Life Sciences, Jew and Sul review the widely-used approaches for variant calling and quality control. This cover features a scheme from their review, highlighting the conversion of a biological sample, such as blood or saliva, into a digital representation of genetic variation found in an individual.