Issues

Mapping gene signatures according to their expression in different immune landscapes of breast (BRCA), lung (LUAD) and colon (COAD) carcinoma, and melanoma (SKCM); signatures selectively expressed in the immune-active (ICR4) landscape are shown in red, those selectively expressed in the immune-silent (ICR1) landscape are shown as blue and those that are ubiquitously expressed independent of immune landscape are white. The image is based on Figure 1 in this issue's opening article (Lu et al., pages 411–419) in which the authors look at how cancer cells go through a conserved evolutionary bottleneck facing a Two-Option Choice to evade recognition by the immune competent host: they can either adopt a clean oncogenic process devoid of immunogenic stimuli (immune-silent tumors) or display an entropic biology prone to immune recognition (immune-active tumors).