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December 2020
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Arginine-rich dipeptide repeat proteins (R-DPRs) disrupt various phase-separated compartments in neurodegenerative disease. In this special Phase Transitions issue of Emerging Topics in Life Sciences, Odeh and Shorter discuss the therapeutic strategies utilised to combat the deleterious effects of R-DPRs. These include the use of small molecule inhibitors, antisense oligonucleotides (ASOs), antibody immunotherapy (anti-DPRs), and “bait” RNAs. Find out more on pages 293–305.
ISSN 2397-8554
EISSN 2397-8562
In this Issue
Phase Transitions
Review Articles
Coordination of transcription, processing, and export of highly expressed RNAs by distinct biomolecular condensates
Emerg Top Life Sci (2020) 4 (3): 281–291.
Intrinsically disordered protein regions and phase separation: sequence determinants of assembly or lack thereof
Emerg Top Life Sci (2020) 4 (3): 307–329.
