... of the host are highlighted. The malaria parasite Plasmodium infects red blood cells and extensively refurbishes these terminally differentiated cells. Cholesterol depletion and an altered intracellular calcium ion homeostasis can lead to disruption in erythrocyte membrane asymmetry and increased exposure...

...Roberto Docampo; Lorenz von Seidlein; Borimas Hanboonkunupakarn; Podjanee Jittmala; Sasithon Pukrittayakamee RTS,S/AS01 is the most advanced vaccine to prevent malaria. It is safe and moderately effective. A large pivotal phase III trial in over 15 000 young children in sub-Saharan Africa completed...

...Roberto Docampo; Catherine J. Merrick Plasmodium falciparum is a protozoan parasite that causes the most severe form of human malaria. Five other Plasmodium species can also infect humans — P. vivax , P. malariae , P. ovale curtisi , P. ovale wallikeri and P. knowlesi — but P. falciparum...

...Roberto Docampo; Frank Lennartz; Thomas Lavstsen; Matthew K. Higgins Human infective parasites, such as those that cause malaria, are highly adapted to evade clearance by the immune system. In situations where they must maintain prolonged interactions with molecules of their host, they often use...

...Roberto Docampo; Michael F. Good; Stephanie K. Yanow Malaria vaccine approaches can be divided into ‘subunit’ and ‘whole parasite’, and these can be directed at the sporozoite, liver stage, asexual or sexual stages. All combinations of approach and stage are under development with the exception...

...Roberto Docampo; Colin J. Sutherland The vast majority of malaria patients worldwide are currently treated with combination therapy comprising one of the artemisinin family of drugs, characterised by rapid action and short plasma half-life, co-formulated with a longer-lasting drug from the amino...