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Keywords: phase separation
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Emerg Top Life Sci (2020) 4 (3): 307–329.
Published: 20 October 2020
... separation (LLPS). IDRs are frequently found to be enriched in phase-separated compartments. Due to this observation, the presence of an IDR in a protein is frequently assumed to be diagnostic of its ability to phase separate. In this review, we clarify the role of IDRs in biological assembly and explore...
Includes: Supplementary data
Emerg Top Life Sci (2020) 4 (3): 247–261.
Published: 13 October 2020
... that terminate filament growth. In vitro and in initial descriptions of cellular phenomena [ 11 ], the formation of condensates has been explored analogous to passive phase separation, which does not require the consumption of a chemical energy source such as ATP. However, active processes triggering...
Emerg Top Life Sci (2020) 4 (3): 293–305.
Published: 08 July 2020
... between R-DPRs and aberrations in liquid–liquid phase separation (LLPS). In this review, we showcase several potential mechanisms by which R-DPRs disrupt various phase-separated compartments to elicit deleterious neurodegeneration. We also discuss potential therapeutic strategies to counter R-DPR toxicity...
Emerg Top Life Sci (2020) 4 (3): 355–364.
Published: 23 June 2020
...M. Sankaranarayanan; Timothy T. Weil Drosophila eggs are highly polarised cells that use RNA–protein complexes to regulate storage and translational control of maternal RNAs. Ribonucleoprotein granules are a class of biological condensates that form predominantly by intracellular phase separation...
Emerg Top Life Sci (2020) 4 (3): 281–291.
Published: 27 April 2020
... recruited to super-enhancers create phase-separated condensates. Transcription initiates within or at the surface of these phase-separated droplets and the phosphorylation of Pol II, associated with transcription initiation and elongation, dissociates Pol II from these domains leading to engagement...