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Keywords: phase separation
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Emerg Top Life Sci (2023) 7 (1): 55–65.
Published: 06 January 2023
... ) 15 11 2022 14 12 2022 20 12 2022 © 2023 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society and the Royal Society of Biology 2023 cryo-EM lipid rafts liquid-disordered liquid-ordered nanodomains phase separation Tahara et al...
Emerg Top Life Sci (2020) 4 (3): 247–261.
Published: 13 October 2020
... ]. In their landmark study Li et al. [ 2 ] showcased how such multivalent signaling proteins form phase-separated compartments depending on the phosphorylation state of nephrin. Above the saturation concentration for condensation, the activity of regulators increases sharply and actin polymerization is nonlinearly...
Emerg Top Life Sci (2020) 4 (3): 293–305.
Published: 08 July 2020
... between R-DPRs and aberrations in liquid–liquid phase separation (LLPS). In this review, we showcase several potential mechanisms by which R-DPRs disrupt various phase-separated compartments to elicit deleterious neurodegeneration. We also discuss potential therapeutic strategies to counter R-DPR toxicity...
Emerg Top Life Sci (2020) 4 (3): 355–364.
Published: 23 June 2020
...M. Sankaranarayanan; Timothy T. Weil Drosophila eggs are highly polarised cells that use RNA–protein complexes to regulate storage and translational control of maternal RNAs. Ribonucleoprotein granules are a class of biological condensates that form predominantly by intracellular phase separation...
Emerg Top Life Sci (2020) 4 (3): 281–291.
Published: 27 April 2020
... recruited to super-enhancers create phase-separated condensates. Transcription initiates within or at the surface of these phase-separated droplets and the phosphorylation of Pol II, associated with transcription initiation and elongation, dissociates Pol II from these domains leading to engagement...