NMR spectroscopy is a powerful technique that can provide valuable structural information for drug discovery endeavors. Here, we discuss the strengths (and limitations) of NMR applications to structure-based drug discovery, highlighting the different levels of resolution and throughput obtainable. Additionally, the emerging field of paramagnetic NMR in drug discovery and recent developments in approaches to speed up and automate protein-observed NMR data collection and analysis are discussed.
Review Article| November 08 2017
NMR in structure-based drug design
Marta G. Carneiro;
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Rob L.M. van Montfort, Paul Workman, Marta G. Carneiro, Eiso AB, Stephan Theisgen, Gregg Siegal; NMR in structure-based drug design. Essays Biochem 8 November 2017; 61 (5): 485–493. doi: https://doi.org/10.1042/EBC20170037
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