Although cells are a part of the whole organism, classical dogma emphasizes that individual cells function autonomously. Many physiological and pathological conditions, including cancer, and metabolic and neurodegenerative diseases, have been considered mechanistically as cell-autonomous pathologies, meaning those that damage or defect within a selective population of affected cells suffice to produce disease. It is becoming clear, however, that cells and cellular processes cannot be considered in isolation. Best known for shuttling cytoplasmic content to the lysosome for degradation and repurposing of recycled building blocks such as amino acids, nucleotides, and fatty acids, autophagy serves a housekeeping function in every cell and plays key roles in cell development, immunity, tissue remodeling, and homeostasis with the surrounding environment and the distant organs. In this review, we underscore the importance of taking interactions with the microenvironment into consideration while addressing the cell autonomous and non-autonomous functions of autophagy between cells of the same and different types and in physiological and pathophysiological situations.
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December 2017
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This issue of Essays in Biochemistry covers a range of topics in autophagy signalling, touching on emerging new details on the mechanisms of autophagy regulation, novel aspects of selective autophagy and how autophagy functions in organelle homeostasis. It also looks at how autophagy research is leading to better understanding of human disease and plant biology that can be exploited for the benefit of society. Cover image credit: Kateryna Kon (Shutterstock: 494829457)Close Modal
Review Article|
December 12 2017
To be or not to be cell autonomous? Autophagy says both
Nina Fenouille
;
Nina Fenouille
*
1Institut Necker-Enfants Malades (INEM), INSERM U1151-CNRS UMR 8253, Paris F-75993, France
2Université Paris Descartes-Sorbonne Paris Cité, Paris F-75006, France
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Anna Chiara Nascimbeni
;
Anna Chiara Nascimbeni
*
1Institut Necker-Enfants Malades (INEM), INSERM U1151-CNRS UMR 8253, Paris F-75993, France
2Université Paris Descartes-Sorbonne Paris Cité, Paris F-75006, France
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Joëlle Botti-Millet
;
Joëlle Botti-Millet
1Institut Necker-Enfants Malades (INEM), INSERM U1151-CNRS UMR 8253, Paris F-75993, France
3Université Paris Diderot-Sorbonne Paris Cité, Paris F-75013, France
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Nicolas Dupont
;
Nicolas Dupont
1Institut Necker-Enfants Malades (INEM), INSERM U1151-CNRS UMR 8253, Paris F-75993, France
2Université Paris Descartes-Sorbonne Paris Cité, Paris F-75006, France
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Etienne Morel
;
Etienne Morel
1Institut Necker-Enfants Malades (INEM), INSERM U1151-CNRS UMR 8253, Paris F-75993, France
2Université Paris Descartes-Sorbonne Paris Cité, Paris F-75006, France
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Patrice Codogno
1Institut Necker-Enfants Malades (INEM), INSERM U1151-CNRS UMR 8253, Paris F-75993, France
2Université Paris Descartes-Sorbonne Paris Cité, Paris F-75006, France
Correspondence: Patrice Codogno (patrice.codogno@inserm.fr)
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Essays Biochem (2017) 61 (6): 649–661.
Article history
Received:
September 13 2017
Revision Received:
October 13 2017
Accepted:
October 16 2017
Citation
Jon D. Lane, Viktor I. Korolchuk, James T. Murray, Nina Fenouille, Anna Chiara Nascimbeni, Joëlle Botti-Millet, Nicolas Dupont, Etienne Morel, Patrice Codogno; To be or not to be cell autonomous? Autophagy says both. Essays Biochem 12 December 2017; 61 (6): 649–661. doi: https://doi.org/10.1042/EBC20170025
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