The proteolytic processing of the amyloid-beta protein precursor plays a key role in the development of Alzheimer's disease. Cleavage of the amyloid-beta protein precursor may occur via two pathways, both of which involve the action of proteases called secretases. One pathway, involving beta- and gamma-secretase, liberates amyloid-beta protein, a protein associated with the neurodegeneration seen in Alzheimer's disease. The alternative pathway, involving alpha-secretase, precludes amyloid-beta protein formation. In this review, we describe the progress that has been made in identifying the secretases and their potential as therapeutic targets in the treatment or prevention of Alzheimer's disease.
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Review Article| October 01 2002
Proteolytic processing of the amyloid-beta protein precursor of Alzheimer's disease
Janelle Nunan ;
Essays Biochem (2002) 38: 37–49.
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Nigel M. Hooper, Janelle Nunan, David H Small; Proteolytic processing of the amyloid-beta protein precursor of Alzheimer's disease. Essays Biochem 1 October 2002; 38 37–49. doi: https://doi.org/10.1042/bse0380037
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