Protease data mining can take advantage both of the many specialist, Web-available databases that cover the genetic, protein and nucleic acid sequence information that is specific to a variety of organisms, and of a flexible, but defined, classification system. However, precomputed data, such as gene predictions, should be used with care. Unless there is definitive supporting information, ideally sequencing of a cDNA to show that the predictions are accurate, followed by expression and biochemical characterization of the predicted protein, the predicted gene and its product remains a possibility, rather than a certainty.
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Review Article| October 01 2002
Mining proteases in the genome databases
Essays Biochem (2002) 38: 185–196.
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Nigel M. Hooper, David Coates; Mining proteases in the genome databases. Essays Biochem 1 October 2002; 38 185–196. doi: https://doi.org/10.1042/bse0380185
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