Misfolded endoplasmic reticulum (ER) proteins are eliminated by the retrotranslocation pathway in eukaryotes, which is an important physiological adaptation to ER stress. This pathway can be hijacked by certain viruses to destroy folded cellular proteins, such as MHC class I heavy chain. Recent studies have highlighted the importance of the ubiquitin–proteasome system (UPS) in this process.
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Review Article| October 01 2005
The role of the ubiquitin–proteasome system in ER quality control
Essays Biochem (2005) 41: 99–112.
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John Mayer, Robert Layfield, Yihong Ye; The role of the ubiquitin–proteasome system in ER quality control. Essays Biochem 1 October 2005; 41 99–112. doi: https://doi.org/10.1042/bse0410099
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