Cell signalling pathways and networks are complex and often non-linear. Signalling pathways can be represented as systems of biochemical reactions that can be modelled using differential equations. Computational modelling of cell signalling pathways is emerging as a tool that facilitates mechanistic understanding of complex biological systems. Mathematical models are also used to generate predictions that may be tested experimentally. In the present chapter, the various steps involved in building models of cell signalling pathways are discussed. Depending on the nature of the process being modelled and the scale of the model, different mathematical formulations, ranging from stochastic representations to ordinary and partial differential equations are discussed. This is followed by a brief summary of some recent modelling successes and the state of future models.
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Olaf Wolkenhauer; Peter Wellstead; Kwang-Hyun Cho
Review Article| September 30 2008
Modelling cellular signalling systems
Padmini Rangamani ;
Padmini Rangamani 1
1Department of Pharmacology and Systems Therapeutics, Mount Sinai School of Medicine, One Gustave L. Levy Place, New York, NY 10029, U.S.A.
1To whom correspondence should be addressed (email firstname.lastname@example.org).
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Essays Biochem (2008) 45: 83–94.
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Olaf Wolkenhauer, Peter Wellstead, Kwang-Hyun Cho, Padmini Rangamani, Ravi Iyengar; Modelling cellular signalling systems. Essays Biochem 30 September 2008; 45 83–94. doi: https://doi.org/10.1042/bse0450083
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