Sensitivity analysis addresses the manner in which model behaviour depends on model parametrization. Global sensitivity analysis makes use of statistical tools to address system behaviour over a wide range of operating conditions, whereas local sensitivity analysis focuses attention on a specific set of nominal parameter values. This narrow focus allows a complete analytical treatment and straightforward interpretation in the local case. Sensitivity analysis is a valuable tool for model construction and interpretation, and can be applied in medicine and biotechnology to predict the effect of interventions.

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