Sensitivity analysis addresses the manner in which model behaviour depends on model parametrization. Global sensitivity analysis makes use of statistical tools to address system behaviour over a wide range of operating conditions, whereas local sensitivity analysis focuses attention on a specific set of nominal parameter values. This narrow focus allows a complete analytical treatment and straightforward interpretation in the local case. Sensitivity analysis is a valuable tool for model construction and interpretation, and can be applied in medicine and biotechnology to predict the effect of interventions.
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Olaf Wolkenhauer; Peter Wellstead; Kwang-Hyun Cho
Review Article| September 30 2008
Sensitivity analysis: from model parameters to system behaviour
Essays Biochem (2008) 45: 177–194.
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Olaf Wolkenhauer, Peter Wellstead, Kwang-Hyun Cho, Brian Ingalls; Sensitivity analysis: from model parameters to system behaviour. Essays Biochem 30 September 2008; 45 177–194. doi: https://doi.org/10.1042/bse0450177
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