From their very beginning to the present day, mitochondria have evolved to become a crucial organelle within the cell. The mitochondrial genome encodes only 37 genes, but its compact structure and minimal redundancy results in mutations on the mitochondrial genome being an important cause of genetic disease. In the present chapter we describe the up-to-date knowledge about mitochondrial DNA structure and function, and describe some of the consequences of defective function including disease and aging.
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Review Article| June 14 2010
Mitochondrial DNA and genetic disease
Kim J. Krishnan ;
Doug M. Turnbull
Doug M. Turnbull 1
1Mitochondrial Research Group, Newcastle University Centre for Brain Ageing and Vitality, Institute for Ageing and Health, Newcastle University, Newcastle NE2 4HH, U.K.
1To whom correspondence should be addressed (email@example.com).
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Essays Biochem (2010) 47: 139–151.
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Guy C. Brown, Michael P. Murphy, Kim J. Krishnan, Doug M. Turnbull; Mitochondrial DNA and genetic disease. Essays Biochem 14 June 2010; 47 139–151. doi: https://doi.org/10.1042/bse0470139
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