Chromosome breaks are dangerous business, carrying the risk of loss of genetic information or, even worse, misrepair of the break, leading to outcomes such as dicentric chromosomes or oncogenic translocations. Yet V(D)J recombination, a process that breaks, rearranges and repairs chromosomes, is crucial to the development of the adaptive immune system, for it gives B- and T-cells the capacity to generate a virtually unlimited repertoire of antigen receptor proteins to combat an equally vast array of antigens. To minimize the risks inherent in chromosomal breakage, V(D)J recombination is carefully orchestrated at multiple levels, ranging from DNA sequence requirements all the way up to chromatin conformation and nuclear architecture. In the present chapter we introduce various regulatory controls, with an emphasis on epigenetic mechanisms and recent work that has begun to elucidate their interdependence.
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Hans J. Lipps; Jan Postberg; Dean A. Jackson
Review Article| September 20 2010
Epigenetic regulation of V(D)J recombination
Kristen Johnson ;
Julie Chaumeil ;
Jane A. Skok
Jane A. Skok 2
*Department of Pathology, New York University School of Medicine, 550 1st Avenue, MSB 531, New York, NY 10016, U.S.A.
†The Department of Immunology and Molecular Pathology, Division of Infection and Immunity, University College London, London W1T 4JF, U.K.
2To whom correspondence should be addressed (Jane.Skok@nyumc.org).
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Essays Biochem (2010) 48: 221–243.
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Hans J. Lipps, Jan Postberg, Dean A. Jackson, Kristen Johnson, Julie Chaumeil, Jane A. Skok; Epigenetic regulation of V(D)J recombination. Essays Biochem 20 September 2010; 48 221–243. doi: https://doi.org/10.1042/bse0480221
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