α-Syn (α-synuclein) is a small soluble acidic protein that is extensively expressed in the nervous system. Genetic, clinical and experimental studies demonstrate that α-syn is strongly implicated in the pathogenesis of PD (Parkinson's disease). However, the pathogenic mechanism remains elusive. In the present chapter, we first describe the normal expression and potential physiological functions of α-syn. Then, we introduce recent research progress related to the pathogenic role of α-syn in PD, with special emphasis on how α-syn oligomers cause the preferential degeneration of dopaminergic neurons in the substantia nigra and the spreading of α-syn pathology in the brain of PD patients.
Skip Nav Destination
Review Article| August 18 2014
Role of α-synuclein in neurodegeneration: implications for the pathogenesis of Parkinson's disease
Shun Yu ;
Piu Chan 1
Department of Neurobiology, Beijing Institute of Geriatric Medical and Research Center, Xuanwu Hospital, Capital Medical University, Changchun Street 45, Xicheng District, Beijing 100053, China
1To whom correspondence should be addressed (email firstname.lastname@example.org).
Search for other works by this author on:
Essays Biochem (2014) 56: 125–135.
- Views Icon Views
- Share Icon Share
Sarah Perrett, Shun Yu, Piu Chan; Role of α-synuclein in neurodegeneration: implications for the pathogenesis of Parkinson's disease. Essays Biochem 18 August 2014; 56 125–135. doi: https://doi.org/10.1042/bse0560125
Download citation file:
Don't already have an account? Register
Get Access To This Article
Buy This Article