Sterols are a critical component of cell membranes of eukaryotes. In mammalian cells there is approximately a six-fold range in the cholesterol content in various organelles. The cholesterol content of membranes plays an important role in organizing membranes for signal transduction and protein trafficking as well as in modulating the physiochemical properties of membranes. Cholesterol trafficking among organelles is highly dynamic and is mediated by both vesicular and non-vesicular processes. Several proteins have been proposed to mediate inter-organelle trafficking of cholesterol. However, several aspects of the mechanisms involved in regulating trafficking and distribution of cholesterol remain to be elucidated. In the present chapter, we discuss the cellular mechanisms involved in cholesterol distribution and the trafficking processes involved in maintaining sterol homoeostasis.
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Review Article| February 06 2015
Cholesterol trafficking and distribution
David B. Iaea ;
David B. Iaea
*Department of Biochemistry, Weill Cornell Medical College, 1300 York Ave, New York, NY 10065, U.S.A.
†Weill Cornell Medical College, Rockefeller University, and Memorial Sloan-Kettering Cancer Center Tri-Institutional Chemical Biology Program, New York, NY 10065, U.S.A.
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Essays Biochem (2015) 57: 43–55.
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Ingela Parmryd, David B. Iaea, Frederick R. Maxfield; Cholesterol trafficking and distribution. Essays Biochem 15 February 2015; 57 43–55. doi: https://doi.org/10.1042/bse0570043
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