Gibberellins (GAs) are phytohormones that regulate growth and development. DELLA proteins repress GA responses. GA binding to its receptor triggers a series of events that culminate in the destruction of DELLA proteins by the 26S proteasome, which removes the repression of GA signalling. DELLA proteins are transcription co-activators that induce the expression of genes which encode products that inhibit GA responses. In addition to repressing GA responses, DELLA proteins influence the activity of other signalling pathways and serve as a central hub from which other pathways influence GA signalling. In this role, DELLA proteins bind to and inhibit proteins, including transcription factors that act in the signalling pathways of other hormones and light. The binding of these proteins to DELLA proteins also inhibits DELLA activity. GA signalling is subject to homoeostatic regulation through GA-induced repression of GA biosynthesis gene expression, and increased production of the GA receptor and enzymes that catabolize bioactive GAs. This review also discusses the nature of mutant DELLA alleles that are used to produce high-yielding ‘Green Revolution’ cereal varieties, and highlights important gaps in our knowledge of GA signalling.
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Review Article| September 15 2015
GA signalling and cross-talk with other signalling pathways
Vai S. Lor;
Neil E. Olszewski
Neil E. Olszewski 1
Department of Plant Biology and the Microbial and Plant Genomics Institute, 250 Biological Sciences Center, 1445 Gortner Avenue, St Paul, MN 55108, U.S.A.
1To whom correspondence should be addressed (email firstname.lastname@example.org).
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Essays Biochem (2015) 58: 49–60.
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Thomas Guilfoyle, Gretchen Hagen, Vai S. Lor, Neil E. Olszewski; GA signalling and cross-talk with other signalling pathways. Essays Biochem 15 September 2015; 58 49–60. doi: https://doi.org/10.1042/bse0580049
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