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July 2017
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This issue explores the molecular and cellular mechanisms which underpin the process of ageing. Guest Edited by Professor Tom Kirkwood, CBE and Dr Viktor Korolchuk of the Newcastle University Institute for Ageing and Health, the issue includes reviews on mechanisms involved in ageing include genome instability and redox stress as well as insights from systems biology and approaches for extending the human healthspan. - PDF Icon PDF LinkTable of Contents
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ISSN 0071-1365
EISSN 1744-1358
In this Issue
Biological Mechanisms of Ageing
Review Articles
How and why do toxic conformers of aberrant proteins accumulate during ageing?
Essays Biochem (2017) 61 (3): 317–324.
The role of attenuated redox and heat shock protein responses in the age-related decline in skeletal muscle mass and function
Essays Biochem (2017) 61 (3): 339–348.
Differential control of ageing and lifespan by isoforms and splice variants across the mTOR network
Essays Biochem (2017) 61 (3): 349–368.
Systems modelling ageing: from single senescent cells to simple multi-cellular models
Alvaro Martinez Guimera; Ciaran Welsh; Piero Dalle Pezze; Nicola Fullard; Glyn Nelson; Mathilde F. Roger; Stefan A. Przyborski; Daryl P. Shanley
Essays Biochem (2017) 61 (3): 369–377.
Proteomics and metabolomics in ageing research: from biomarkers to systems biology
Essays Biochem (2017) 61 (3): 379–388.
Approaches for extending human healthspan: from antioxidants to healthspan pharmacology
Essays Biochem (2017) 61 (3): 389–399.