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Articles

Oxysterol sulfates in fluids, cells and tissues: how much do we know about their clinical significance, biological relevance and biophysical implications?

Ana Reis, Irundika H.K. Dias
Journal: Essays in Biochemistry
Essays Biochem (2024) 68 (4): 401–410.
https://doi.org/10.1042/EBC20230090
Published: 04 December 2024
View articletitled, Oxysterol sulfates in fluids, cells and tissues: how much do we know about their clinical significance, biological relevance and biophysical implications?
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Articles

Interactions of proteins with heparan sulfate

Faizah S. Alotaibi, Marim M.R. Alsadun, Sarah A. Alsaiari, Krithika Ramakrishnan, Edwin A. Yates, David G. Fernig
Journal: Essays in Biochemistry
Essays Biochem (2024) 68 (4): 479–489.
https://doi.org/10.1042/EBC20230093
Published: 04 December 2024
View articletitled, Interactions of proteins with heparan sulfate
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Articles

The structural biology and dynamics of malate dehydrogenases

Christopher E. Berndsen, Jessica K. Bell
Journal: Essays in Biochemistry
Essays Biochem (2024) 68 (2): 57–72.
https://doi.org/10.1042/EBC20230082
Published: 03 October 2024
View articletitled, The structural biology and dynamics of malate dehydrogenases
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Includes: Supplementary data
Articles

Developments in rapid hydrogen–deuterium exchange methods

Vimanda Chow, Esther Wolf, Cristina Lento, Derek J. Wilson
Journal: Essays in Biochemistry
Essays Biochem (2023) 67 (2): 165–174.
https://doi.org/10.1042/EBC20220174
Published: 29 March 2023
View articletitled, Developments in rapid hydrogen–deuterium exchange methods
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Articles

Mass spectrometry of intact membrane proteins: shifting towards a more native-like context

Abraham Oluwole, Denis Shutin, Jani R. Bolla
Journal: Essays in Biochemistry
Essays Biochem (2023) 67 (2): 201–213.
https://doi.org/10.1042/EBC20220169
Published: 29 March 2023
View articletitled, Mass spectrometry of intact membrane proteins: shifting towards a more native-like context
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Articles

Protein–RNA interactions: from mass spectrometry to drug discovery

Benjamin Steinmetz, Izabela Smok, Maria Bikaki, Alexander Leitner
Journal: Essays in Biochemistry
Essays Biochem (2023) 67 (2): 175–186.
https://doi.org/10.1042/EBC20220177
Published: 29 March 2023
View articletitled, Protein–RNA interactions: from mass spectrometry to drug discovery
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Articles

Hydrogen/deuterium exchange-mass spectrometry of integral membrane proteins in native-like environments: current scenario and the way forward

Waqas Javed, Damon Griffiths, Argyris Politis
Journal: Essays in Biochemistry
Essays Biochem (2023) 67 (2): 187–200.
https://doi.org/10.1042/EBC20220173
Published: 29 March 2023
View articletitled, Hydrogen/deuterium exchange-mass spectrometry of integral membrane proteins in native-like environments: current scenario and the way forward
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Articles

Electrospray ion beam deposition plus low-energy electron holography as a tool for imaging individual biomolecules

Hannah Ochner, Stephan Rauschenbach, Luigi Malavolti
Journal: Essays in Biochemistry
Essays Biochem (2023) 67 (2): 151–163.
https://doi.org/10.1042/EBC20220165
Published: 29 March 2023
View articletitled, Electrospray ion beam deposition plus low-energy electron holography as a tool for imaging individual biomolecules
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Articles

A special issue of Essays in Biochemistry on structural mass spectrometry

Hannah M. Britt, Rebecca Beveridge, Antonio N. Calabrese
Journal: Essays in Biochemistry
Essays Biochem (2023) 67 (2): 147–149.
https://doi.org/10.1042/EBC20230006
Published: 29 March 2023
View articletitled, A special issue of Essays in Biochemistry on structural mass spectrometry
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Articles

Crossroads between copper ions and amyloid formation in Parkinson’s disease

Pernilla Wittung-Stafshede
Journal: Essays in Biochemistry
Essays Biochem (2022) 66 (7): 977–986.
https://doi.org/10.1042/EBC20220043
Published: 16 December 2022
View articletitled, Crossroads between copper ions and amyloid formation in Parkinson’s disease
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Articles

Controlling amyloid formation of intrinsically disordered proteins and peptides: slowing down or speeding up?

Yong Xu, Roberto Maya-Martinez, Sheena E. Radford
Journal: Essays in Biochemistry
Essays Biochem (2022) 66 (7): 959–975.
https://doi.org/10.1042/EBC20220046
Published: 16 December 2022
View articletitled, Controlling amyloid formation of intrinsically disordered proteins and peptides: slowing down or speeding up?
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Articles

Functional benefit of structural disorder for the replication of measles, Nipah and Hendra viruses

Frank Gondelaud, Giulia Pesce, Juliet F. Nilsson, Christophe Bignon, Denis Ptchelkine, Denis Gerlier, Cyrille Mathieu, Sonia Longhi
Journal: Essays in Biochemistry
Essays Biochem (2022) 66 (7): 915–934.
https://doi.org/10.1042/EBC20220045
Published: 16 December 2022
View articletitled, Functional benefit of structural disorder for the replication of measles, Nipah and Hendra viruses
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Includes: Supplementary data
Articles

Functional amyloid in a lipid-like environment: a merry dance of many steps

Daniel E. Otzen
Journal: Essays in Biochemistry
Essays Biochem (2022) 66 (7): 1035–1046.
https://doi.org/10.1042/EBC20220062
Published: 16 December 2022
View articletitled, Functional amyloid in a lipid-like environment: a merry dance of many steps
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Articles

Phase separation of the microtubule-associated protein tau

Pijush Chakraborty, Markus Zweckstetter
Journal: Essays in Biochemistry
Essays Biochem (2022) 66 (7): 1013–1021.
https://doi.org/10.1042/EBC20220066
Published: 16 December 2022
View articletitled, Phase separation of the microtubule-associated protein tau
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Articles

Biological soft matter: intrinsically disordered proteins in liquid–liquid phase separation and biomolecular condensates

Alexander V. Fonin, Iuliia A. Antifeeva, Irina M. Kuznetsova, Konstantin K. Turoverov, Boris Y. Zaslavsky, Prakash Kulkarni, Vladimir N. Uversky
Journal: Essays in Biochemistry
Essays Biochem (2022) 66 (7): 831–847.
https://doi.org/10.1042/EBC20220052
Published: 16 December 2022
View articletitled, Biological soft matter: intrinsically disordered proteins in liquid–liquid phase separation and biomolecular condensates
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Articles

Different states and the associated fates of biomolecular condensates

Srivastav Ranganathan, Junlang Liu, Eugene Shakhnovich
Journal: Essays in Biochemistry
Essays Biochem (2022) 66 (7): 849–862.
https://doi.org/10.1042/EBC20220054
Published: 16 December 2022
View articletitled, Different states and the associated fates of biomolecular condensates
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Articles

How phosphorylation impacts intrinsically disordered proteins and their function

Estella A. Newcombe, Elise Delaforge, Rasmus Hartmann-Petersen, Karen Skriver, Birthe B. Kragelund
Journal: Essays in Biochemistry
Essays Biochem (2022) 66 (7): 901–913.
https://doi.org/10.1042/EBC20220060
Published: 16 December 2022
View articletitled, How phosphorylation impacts intrinsically disordered proteins and their function
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Articles

The chameleonic behavior of p53 in health and disease: the transition from a client to an aberrant condensate scaffold in cancer

Mayra A. Marques, Guilherme A.P. de Oliveira, Jerson L. Silva
Journal: Essays in Biochemistry
Essays Biochem (2022) 66 (7): 1023–1033.
https://doi.org/10.1042/EBC20220064
Published: 16 December 2022
View articletitled, The chameleonic behavior of p53 in health and disease: the transition from a client to an aberrant condensate scaffold in cancer
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Articles

Phase separation and other forms of α-Synuclein self-assemblies

Manisha Poudyal, Arunima Sakunthala, Semanti Mukherjee, Laxmikant Gadhe, Samir K Maji
Journal: Essays in Biochemistry
Essays Biochem (2022) 66 (7): 987–1000.
https://doi.org/10.1042/EBC20220055
Published: 16 December 2022
View articletitled, Phase separation and other forms of α-Synuclein self-assemblies
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Articles

Shapeshifting tau: from intrinsically disordered to paired-helical filaments

Kurtis Mengham, Youssra Al-Hilaly, Sebastian Oakley, Kamillia Kasbi, Mahmoud B. Maina, Louise C. Serpell
Journal: Essays in Biochemistry
Essays Biochem (2022) 66 (7): 1001–1011.
https://doi.org/10.1042/EBC20220150
Published: 16 December 2022
View articletitled, Shapeshifting tau: from intrinsically disordered to paired-helical filaments
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Articles

Protein interactions: anything new?

Susana Barrera-Vilarmau, João M.C. Teixeira, Monika Fuxreiter
Journal: Essays in Biochemistry
Essays Biochem (2022) 66 (7): 821–830.
https://doi.org/10.1042/EBC20220044
Published: 16 December 2022
View articletitled, Protein interactions: anything new?
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Articles

NMR insights into dynamic, multivalent interactions of intrinsically disordered regions: from discrete complexes to condensates

Rashik Ahmed, Julie D. Forman-Kay
Journal: Essays in Biochemistry
Essays Biochem (2022) 66 (7): 863–873.
https://doi.org/10.1042/EBC20220056
Published: 16 December 2022
View articletitled, NMR insights into dynamic, multivalent interactions of intrinsically disordered regions: from discrete complexes to condensates
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Articles

The biophysics of disordered proteins from the point of view of single-molecule fluorescence spectroscopy

Jasmine Cubuk, Melissa D. Stuchell-Brereton, Andrea Soranno
Journal: Essays in Biochemistry
Essays Biochem (2022) 66 (7): 875–890.
https://doi.org/10.1042/EBC20220065
Published: 16 December 2022
View articletitled, The biophysics of disordered proteins from the point of view of single-molecule fluorescence spectroscopy
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Articles

Evolution of SLiM-mediated hijack functions in intrinsically disordered viral proteins

Juliana Glavina, Nicolas Palopoli, Lucía Beatriz Chemes
Journal: Essays in Biochemistry
Essays Biochem (2022) 66 (7): 945–958.
https://doi.org/10.1042/EBC20220059
Published: 16 December 2022
View articletitled, Evolution of SLiM-mediated hijack functions in intrinsically disordered viral proteins
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Articles

Unravelling the microscopic characteristics of intrinsically disordered proteins upon liquid–liquid phase separation

Si Wu, Jitao Wen, Sarah Perrett
Journal: Essays in Biochemistry
Essays Biochem (2022) 66 (7): 891–900.
https://doi.org/10.1042/EBC20220148
Published: 16 December 2022
View articletitled, Unravelling the microscopic characteristics of intrinsically disordered proteins upon liquid–liquid phase separation
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Articles

Shapeshifting proteins: the role of structural disorder and conformational plasticity in physiology and disease

Samrat Mukhopadhyay
Journal: Essays in Biochemistry
Essays Biochem (2022) 66 (7): 817–819.
https://doi.org/10.1042/EBC20220197
Published: 16 December 2022
View articletitled, Shapeshifting proteins: the role of structural disorder and conformational plasticity in physiology and disease
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Articles

Biomechanics of cancer stem cells

Xi Chen, Kai Tang, Xueyi Li, Cunyu Zhang, Ying Xin, Keming Li, Youhua Tan
Journal: Essays in Biochemistry
Essays Biochem (2022) 66 (4): 359–369.
https://doi.org/10.1042/EBC20220014
Published: 16 September 2022
View articletitled, Biomechanics of cancer stem cells
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Articles

Laser-based bioprinting for multilayer cell patterning in tissue engineering and cancer research

Haowei Yang, Kai-Hung Yang, Roger J. Narayan, Shaohua Ma
Journal: Essays in Biochemistry
Essays Biochem (2021) 65 (3): 409–416.
https://doi.org/10.1042/EBC20200093
Published: 06 August 2021
View articletitled, Laser-based bioprinting for multilayer cell patterning in tissue engineering and cancer research
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Articles

Biology on track: single-molecule visualisation of protein dynamics on linear DNA substrates

Gurleen Kaur, Lisanne M. Spenkelink
Journal: Essays in Biochemistry
Essays Biochem (2021) 65 (1): 5–16.
https://doi.org/10.1042/EBC20200019
Published: 16 April 2021
View articletitled, Biology on track: single-molecule visualisation of protein dynamics on linear DNA substrates
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Articles

Nanopores: a versatile tool to study protein dynamics

In Collection
Protein structure and function
Sonja Schmid, Cees Dekker
Journal: Essays in Biochemistry
Essays Biochem (2021) 65 (1): 93–107.
https://doi.org/10.1042/EBC20200020
Published: 16 April 2021
View articletitled, Nanopores: a versatile tool to study protein dynamics
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Articles

Label-free, mass-sensitive single-molecule imaging using interferometric scattering microscopy

Nikolas Hundt
Journal: Essays in Biochemistry
Essays Biochem (2021) 65 (1): 81–91.
https://doi.org/10.1042/EBC20200023
Published: 16 April 2021
View articletitled, Label-free, mass-sensitive single-molecule imaging using interferometric scattering microscopy
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Articles

From folding to function: complex macromolecular reactions unraveled one-by-one with optical tweezers

In Collection
Protein structure and function
Pétur O. Heidarsson, Ciro Cecconi
Journal: Essays in Biochemistry
Essays Biochem (2021) 65 (1): 129–142.
https://doi.org/10.1042/EBC20200024
Published: 16 April 2021
View articletitled, From folding to function: complex macromolecular reactions unraveled one-by-one with optical tweezers
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Articles

Studying chromosome biology with single-molecule resolution in Xenopus laevis egg extracts

George Cameron, Hasan Yardimci
Journal: Essays in Biochemistry
Essays Biochem (2021) 65 (1): 17–26.
https://doi.org/10.1042/EBC20200026
Published: 16 April 2021
View articletitled, Studying chromosome biology with single-molecule resolution in Xenopus laevis egg extracts
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Articles

Modelling single-molecule kinetics of helicase translocation using high-resolution nanopore tweezers (SPRNT)

Jonathan M. Craig, Andrew H. Laszlo, Ian C. Nova, Jens H. Gundlach
Journal: Essays in Biochemistry
Essays Biochem (2021) 65 (1): 109–127.
https://doi.org/10.1042/EBC20200027
Published: 16 April 2021
View articletitled, Modelling single-molecule kinetics of helicase translocation using high-resolution nanopore tweezers (SPRNT)
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Articles

DNA hybridisation kinetics using single-molecule fluorescence imaging

Rebecca Andrews
Journal: Essays in Biochemistry
Essays Biochem (2021) 65 (1): 27–36.
https://doi.org/10.1042/EBC20200040
Published: 16 April 2021
View articletitled, DNA hybridisation kinetics using single-molecule fluorescence imaging
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Articles

Integrating single-molecule FRET and biomolecular simulations to study diverse interactions between nucleic acids and proteins

Joshua C. Sanders, Erik D. Holmstrom
Journal: Essays in Biochemistry
Essays Biochem (2021) 65 (1): 37–49.
https://doi.org/10.1042/EBC20200022
Published: 16 April 2021
View articletitled, Integrating single-molecule FRET and biomolecular simulations to study diverse interactions between nucleic acids and proteins
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Articles

Single-molecule optical genome mapping in nanochannels: multidisciplinarity at the nanoscale

Jonathan Jeffet, Sapir Margalit, Yael Michaeli, Yuval Ebenstein
Journal: Essays in Biochemistry
Essays Biochem (2021) 65 (1): 51–66.
https://doi.org/10.1042/EBC20200021
Published: 16 April 2021
View articletitled, Single-molecule optical genome mapping in nanochannels: multidisciplinarity at the nanoscale
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Articles

Challenges of analysing stochastic gene expression in bacteria using single-cell time-lapse experiments

Georgeos Hardo, Somenath Bakshi
Journal: Essays in Biochemistry
Essays Biochem (2021) 65 (1): 67–79.
https://doi.org/10.1042/EBC20200015
Published: 16 April 2021
View articletitled, Challenges of analysing stochastic gene expression in bacteria using single-cell time-lapse experiments
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Articles

Biochemistry: one molecule at a time

Dominika T. Gruszka
Journal: Essays in Biochemistry
Essays Biochem (2021) 65 (1): 1–3.
https://doi.org/10.1042/EBC20210015
Published: 16 April 2021
View articletitled, Biochemistry: one molecule at a time
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Articles

An introduction to the themed issue on RNA biology in China

Zhe Wu
Journal: Essays in Biochemistry
Essays Biochem (2020) 64 (6): 863–866.
https://doi.org/10.1042/EBC20200031
Published: 07 December 2020
View articletitled, An introduction to the themed issue on RNA biology in China
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Articles

Uncovering protein structure

In Collection
Protein structure and function
Elliott J Stollar, David P Smith
Journal: Essays in Biochemistry
Essays Biochem (2020) 64 (4): 649–680.
https://doi.org/10.1042/EBC20190042
Published: 25 September 2020
View articletitled, Uncovering protein structure
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Articles

The whole is greater than the sum of its parts: at the intersection of order, disorder, and kinetochore function

Margaux R. Audett, Thomas J. Maresca
Journal: Essays in Biochemistry
Essays Biochem (2020) 64 (2): 349–358.
https://doi.org/10.1042/EBC20190069
Published: 05 August 2020
View articletitled, The whole is greater than the sum of its parts: at the intersection of order, disorder, and kinetochore function
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Articles

Structural view of the yeast Dam1 complex, a ring-shaped molecular coupler for the dynamic microtubule end

Shaowen Wu, Ekaterina L. Grishchuk
Journal: Essays in Biochemistry
Essays Biochem (2020) 64 (2): 359–370.
https://doi.org/10.1042/EBC20190079
Published: 24 June 2020
View articletitled, Structural view of the yeast Dam1 complex, a ring-shaped molecular coupler for the dynamic microtubule end
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Articles

Druggable binding sites in the multicomponent assemblies that characterise DNA double-strand-break repair through non-homologous end joining

Antonia Kefala Stavridi, Robert Appleby, Shikang Liang, Tom L. Blundell, Amanda K. Chaplin
Journal: Essays in Biochemistry
Essays Biochem (2020) 64 (5): 791–806.
https://doi.org/10.1042/EBC20190092
Published: 24 June 2020
View articletitled, Druggable binding sites in the multicomponent assemblies that characterise DNA double-strand-break repair through non-homologous end joining
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Articles

Microtubules pull the strings: disordered sequences as efficient couplers of microtubule-generated force

Vladimir A. Volkov
Journal: Essays in Biochemistry
Essays Biochem (2020) 64 (2): 371–382.
https://doi.org/10.1042/EBC20190078
Published: 05 June 2020
View articletitled, Microtubules pull the strings: disordered sequences as efficient couplers of microtubule-generated force
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Articles

Keratin intermediate filaments: intermediaries of epithelial cell migration

Sungjun Yoon, Rudolf E. Leube
Journal: Essays in Biochemistry
Essays Biochem (2019) 63 (5): 521–533.
https://doi.org/10.1042/EBC20190017
Published: 11 October 2019
View articletitled, Keratin intermediate filaments: intermediaries of epithelial cell migration
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Includes: Supplementary data
Articles

Nuclear failure, DNA damage, and cell cycle disruption after migration through small pores: a brief review

Charlotte R. Pfeifer, Manasvita Vashisth, Yuntao Xia, Dennis E. Discher
Journal: Essays in Biochemistry
Essays Biochem (2019) 63 (5): 569–577.
https://doi.org/10.1042/EBC20190007
Published: 31 July 2019
View articletitled, Nuclear failure, DNA damage, and cell cycle disruption after migration through small pores: a brief review
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Articles

Microtubules in cell migration

Clare Garcin, Anne Straube
Journal: Essays in Biochemistry
Essays Biochem (2019) 63 (5): 509–520.
https://doi.org/10.1042/EBC20190016
Published: 29 July 2019
View articletitled, Microtubules in cell migration
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Articles

From single bacterial cell imaging towards in vivo single-molecule biochemistry studies

Ulrike Endesfelder
Journal: Essays in Biochemistry
Essays Biochem (2019) 63 (2): 187–196.
https://doi.org/10.1042/EBC20190002
Published: 13 June 2019
View articletitled, From single bacterial cell imaging towards in vivo single-molecule biochemistry studies
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Articles

Dynamic chromatin organization in the cell

Eloise I. Prieto, Kazuhiro Maeshima
Journal: Essays in Biochemistry
Essays Biochem (2019) 63 (1): 133–145.
https://doi.org/10.1042/EBC20180054
Published: 09 April 2019
View articletitled, Dynamic chromatin organization in the cell
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