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Articles

Epigenetics, human imprintome, and chronic diseases

Open Access
Randy L. Jirtle
Journal: Essays in Biochemistry
Essays Biochem (2025) EBC20253015.
https://doi.org/10.1042/EBC20253015
Published: 04 July 2025
View articletitled, Epigenetics, human imprintome, and chronic diseases
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Articles

Modulating immune cells within pancreatic ductal adenocarcinoma via nanomedicine

Open Access
Junyi Lin, Ying Li, Jingjing Sun
Journal: Essays in Biochemistry
Essays Biochem (2025) EBC20243001.
https://doi.org/10.1042/EBC20243001
Published: 26 May 2025
View articletitled, Modulating immune cells within pancreatic ductal adenocarcinoma via nanomedicine
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Includes: Supplementary data
Articles

Immune activation and regulation mediated by immune cell-derived EVs (iEVs)

Open Access
Fei Wang, Xinye Wang, Xuehao Zhang, Mengying Hu
Journal: Essays in Biochemistry
Essays Biochem (2025) EBC20253005.
https://doi.org/10.1042/EBC20253005
Published: 20 May 2025
View articletitled, Immune activation and regulation mediated by immune cell-derived EVs (iEVs)
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Articles

Metal coordination polymer nanoparticles for cancer therapy

Open Access
Zhengzheng Zhang, Isra Rana, Jutaek Nam
Journal: Essays in Biochemistry
Essays Biochem (2025) EBC20253012.
https://doi.org/10.1042/EBC20253012
Published: 10 April 2025
View articletitled, Metal coordination polymer nanoparticles for cancer therapy
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Articles

Potential of bacterial outer membrane vesicles in tumor vaccine: characteristics, advancements, and future directions

Open Access
Yizhe Yang, Yumin Wu
Journal: Essays in Biochemistry
Essays Biochem (2025) EBC20253004.
https://doi.org/10.1042/EBC20253004
Published: 28 March 2025
View articletitled, Potential of bacterial outer membrane vesicles in tumor vaccine: characteristics, advancements, and future directions
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Articles

Emerging strategies in lymph node-targeted nano-delivery systems for tumor immunotherapy

Open Access
Yaoli Zhao, Muzi Tian, Xin Tong, Xiangliang Yang, Lu Gan, Tuying Yong
Journal: Essays in Biochemistry
Essays Biochem (2025) EBC20253008.
https://doi.org/10.1042/EBC20253008
Published: 28 March 2025
View articletitled, Emerging strategies in lymph node-targeted nano-delivery systems for tumor immunotherapy
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Articles

The cGAS-STING pathway in cancer immunity: dual roles, therapeutic strategies, and clinical challenges

Open Access
Beilei Yue, Wenbo Gao, Jonathan F. Lovell, Honglin Jin, Jing Huang
Journal: Essays in Biochemistry
Essays Biochem (2025) EBC20253006.
https://doi.org/10.1042/EBC20253006
Published: 07 March 2025
View articletitled, The cGAS-STING pathway in cancer immunity: dual roles, therapeutic strategies, and clinical challenges
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Articles

Steroid sulfatase and sulfotransferases in the estrogen and androgen action of gynecological cancers: current status and perspectives

Open Access
Tea Lanišnik Rižner, Marija Gjorgoska
Journal: Essays in Biochemistry
Essays Biochem (2024) 68 (4): 411–422.
https://doi.org/10.1042/EBC20230096
Published: 04 December 2024
View articletitled, Steroid sulfatase and sulfotransferases in the estrogen and androgen action of gynecological cancers: current status and perspectives
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Articles

Steroid metabolism and hormonal dynamics in normal and malignant ovaries

Open Access
Lucy I. Beevors, Sudha Sundar, Paul A. Foster
Journal: Essays in Biochemistry
Essays Biochem (2024) 68 (4): 491–507.
https://doi.org/10.1042/EBC20240028
Published: 04 December 2024
View articletitled, Steroid metabolism and hormonal dynamics in normal and malignant ovaries
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Articles

Sulphotransferase-mediated toxification of chemicals in mouse models: effect of knockout or humanisation of SULT genes

Open Access
Hansruedi Glatt, Walter Meinl
Journal: Essays in Biochemistry
Essays Biochem (2024) 68 (4): 523–539.
https://doi.org/10.1042/EBC20240030
Published: 04 December 2024
View articletitled, Sulphotransferase-mediated toxification of chemicals in mouse models: effect of knockout or humanisation of SULT genes
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Articles

NUAK: never underestimate a kinase

Open Access
George L. Skalka, Declan Whyte, Dominika Lubawska, Daniel J. Murphy
Journal: Essays in Biochemistry
Essays Biochem (2024) 68 (3): 295–307.
https://doi.org/10.1042/EBC20240005
Published: 18 November 2024
View articletitled, NUAK: never underestimate a kinase
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Articles

CaMKK2: bridging the gap between Ca 2+ signaling and energy-sensing

Open Access
Luke M. McAloon, Abbey G. Muller, Kevin Nay, Eudora L. Lu, Benoit Smeuninx, Anthony R. Means, Mark A. Febbraio, John W. Scott
Journal: Essays in Biochemistry
Essays Biochem (2024) 68 (3): 309–320.
https://doi.org/10.1042/EBC20240011
Published: 18 November 2024
View articletitled, CaMKK2: bridging the gap between Ca 2+ signaling and energy-sensing
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Articles

Understanding metabolic plasticity at single cell resolution

Open Access
Christina C. Abbate, Jason Hu, John G. Albeck
Journal: Essays in Biochemistry
Essays Biochem (2024) 68 (3): 273–281.
https://doi.org/10.1042/EBC20240002
Published: 18 November 2024
View articletitled, Understanding metabolic plasticity at single cell resolution
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Articles

New developments in AMPK and mTORC1 cross-talk

Open Access
William J. Smiles, Ashley J. Ovens, Bruce E. Kemp, Sandra Galic, Janni Petersen, Jonathan S. Oakhill
Journal: Essays in Biochemistry
Essays Biochem (2024) 68 (3): 321–336.
https://doi.org/10.1042/EBC20240007
Published: 18 November 2024
View articletitled, New developments in AMPK and mTORC1 cross-talk
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Articles

Malate dehydrogenase as a multi-purpose target for drug discovery

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Charles S. Fermaintt, Sarah A. Wacker
Journal: Essays in Biochemistry
Essays Biochem (2024) 68 (2): 147–160.
https://doi.org/10.1042/EBC20230081
Published: 03 October 2024
View articletitled, Malate dehydrogenase as a multi-purpose target for drug discovery
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Articles

Phosphorylation of mammalian cytosolic and mitochondrial malate dehydrogenase: insights into regulation

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Joseph J. Provost, Kathleen A Cornely, Pamela S. Mertz, Celeste N. Peterson, Sophie G. Riley, Harrison J. Tarbox, Shree R. Narasimhan, Andrew J Pulido, Amy L. Springer
Journal: Essays in Biochemistry
Essays Biochem (2024) 68 (2): 183–198.
https://doi.org/10.1042/EBC20230079
Published: 03 October 2024
View articletitled, Phosphorylation of mammalian cytosolic and mitochondrial malate dehydrogenase: insights into regulation
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Articles

Malate dehydrogenase (MDH) in cancer: a promiscuous enzyme, a redox regulator, and a metabolic co-conspirator

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Betsy Leverett, Shane Austin, Jason Tan-Arroyo
Journal: Essays in Biochemistry
Essays Biochem (2024) 68 (2): 135–146.
https://doi.org/10.1042/EBC20230088
Published: 03 October 2024
View articletitled, Malate dehydrogenase (MDH) in cancer: a promiscuous enzyme, a redox regulator, and a metabolic co-conspirator
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Articles

Roles of the oncometabolite enantiomers of 2-hydroxyglutarate and their metabolism by diverse dehydrogenases

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Ivelitza Garcia, Kathleen Cornely, Celeste N. Peterson, Melanie B. Berkmen
Journal: Essays in Biochemistry
Essays Biochem (2024) 68 (2): 161–171.
https://doi.org/10.1042/EBC20230077
Published: 03 October 2024
View articletitled, Roles of the oncometabolite enantiomers of 2-hydroxyglutarate and their metabolism by diverse dehydrogenases
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Articles

Physiology of malate dehydrogenase and how dysregulation leads to disease

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Amy D. Parente, Danielle E. Bolland, Kathryn L. Huisinga, Joseph J. Provost
Journal: Essays in Biochemistry
Essays Biochem (2024) 68 (2): 121–134.
https://doi.org/10.1042/EBC20230085
Published: 03 October 2024
View articletitled, Physiology of malate dehydrogenase and how dysregulation leads to disease
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Articles

Genetics of MDH in humans

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Adam Haberman, Celeste N. Peterson
Journal: Essays in Biochemistry
Essays Biochem (2024) 68 (2): 107–119.
https://doi.org/10.1042/EBC20230078
Published: 03 October 2024
View articletitled, Genetics of MDH in humans
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Articles

De novo priming: driver of immunotherapy responses or epiphenomenon?

Open Access
Alexander L. Young, Tara Lorimer, Sarwah K. Al-Khalidi, Edward W. Roberts
Journal: Essays in Biochemistry
Essays Biochem (2023) 67 (6): 929–939.
https://doi.org/10.1042/EBC20220244
Published: 28 September 2023
View articletitled, De novo priming: driver of immunotherapy responses or epiphenomenon?
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Articles

Immunologically relevant effects of radiation therapy on the tumor microenvironment

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Claudia Galassi, Vanessa Klapp, Silvia C. Formenti, Sandra Demaria, Lorenzo Galluzzi
Journal: Essays in Biochemistry
Essays Biochem (2023) 67 (6): 979–989.
https://doi.org/10.1042/EBC20220248
Published: 28 September 2023
View articletitled, Immunologically relevant effects of radiation therapy on the tumor microenvironment
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Articles

Perivascular tumor-associated macrophages and their role in cancer progression

Open Access
Meriem Bahri, Joanne E. Anstee, James W. Opzoomer, James N. Arnold
Journal: Essays in Biochemistry
Essays Biochem (2023) 67 (6): 919–928.
https://doi.org/10.1042/EBC20220242
Published: 28 September 2023
View articletitled, Perivascular tumor-associated macrophages and their role in cancer progression
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Articles

Tumour-associated macrophages as a potential target to improve natural killer cell-based immunotherapies

Open Access
Takanori Kitamura
Journal: Essays in Biochemistry
Essays Biochem (2023) 67 (6): 1003–1014.
https://doi.org/10.1042/EBC20230002
Published: 28 September 2023
View articletitled, Tumour-associated macrophages as a potential target to improve natural killer cell-based immunotherapies
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Articles

T-cell response to checkpoint blockade immunotherapies: from fundamental mechanisms to treatment signatures

Open Access
Thomas A.E. Elliot, David A.J. Lecky, David Bending
Journal: Essays in Biochemistry
Essays Biochem (2023) 67 (6): 967–977.
https://doi.org/10.1042/EBC20220247
Published: 28 September 2023
View articletitled, T-cell response to checkpoint blockade immunotherapies: from fundamental mechanisms to treatment signatures
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Articles

The role of IFN-γ-signalling in response to immune checkpoint blockade therapy

Open Access
Chun Wai Wong, Yang Yu Huang, Adam Hurlstone
Journal: Essays in Biochemistry
Essays Biochem (2023) 67 (6): 991–1002.
https://doi.org/10.1042/EBC20230001
Published: 28 September 2023
View articletitled, The role of IFN-γ-signalling in response to immune checkpoint blockade therapy
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Articles

DNA sensing in cancer: Pro-tumour and anti-tumour functions of cGAS–STING signalling

Open Access
Otto P.G. Wheeler, Leonie Unterholzner
Journal: Essays in Biochemistry
Essays Biochem (2023) 67 (6): 905–918.
https://doi.org/10.1042/EBC20220241
Published: 28 September 2023
View articletitled, DNA sensing in cancer: Pro-tumour and anti-tumour functions of cGAS–STING signalling
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Articles

Immuno-oncology

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Awen Gallimore, Cathy Tournier
Journal: Essays in Biochemistry
Essays Biochem (2023) 67 (6): 903.
https://doi.org/10.1042/EBC20230071
Published: 28 September 2023
View articletitled, Immuno-oncology
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Articles

Harnessing neutrophil plasticity for HCC immunotherapy

Open Access
Erik Ramon-Gil, Daniel Geh, Jack Leslie
Journal: Essays in Biochemistry
Essays Biochem (2023) 67 (6): 941–955.
https://doi.org/10.1042/EBC20220245
Published: 28 September 2023
View articletitled, Harnessing neutrophil plasticity for HCC immunotherapy
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Articles

Saccharomyces cerevisiae as a tool for deciphering Hsp90 molecular chaperone function

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Sarah J. Backe, Mehdi Mollapour, Mark R. Woodford
Journal: Essays in Biochemistry
Essays Biochem (2023) 67 (5): 781–795.
https://doi.org/10.1042/EBC20220224
Published: 13 September 2023
View articletitled, Saccharomyces cerevisiae as a tool for deciphering Hsp90 molecular chaperone function
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Articles

The chameleonic behavior of p53 in health and disease: the transition from a client to an aberrant condensate scaffold in cancer

Available to Purchase
Mayra A. Marques, Guilherme A.P. de Oliveira, Jerson L. Silva
Journal: Essays in Biochemistry
Essays Biochem (2022) 66 (7): 1023–1033.
https://doi.org/10.1042/EBC20220064
Published: 16 December 2022
View articletitled, The chameleonic behavior of p53 in health and disease: the transition from a client to an aberrant condensate scaffold in cancer
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Articles

Evo-devo perspectives on cancer

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Aurora M. Nedelcu
Journal: Essays in Biochemistry
Essays Biochem (2022) 66 (6): 797–815.
https://doi.org/10.1042/EBC20220041
Published: 08 December 2022
View articletitled, Evo-devo perspectives on cancer
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Articles

Mechanisms of resistance to tyrosine kinase inhibitors in liver cancer stem cells and potential therapeutic approaches

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Ki-Fong Man, Stephanie Ma
Journal: Essays in Biochemistry
Essays Biochem (2022) 66 (4): 371–386.
https://doi.org/10.1042/EBC20220001
Published: 16 September 2022
View articletitled, Mechanisms of resistance to tyrosine kinase inhibitors in liver cancer stem cells and potential therapeutic approaches
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Articles

WNT signaling and cancer stemness

Open Access
Masuko Katoh, Masaru Katoh
Journal: Essays in Biochemistry
Essays Biochem (2022) 66 (4): 319–331.
https://doi.org/10.1042/EBC20220016
Published: 16 September 2022
View articletitled, WNT signaling and cancer stemness
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Articles

Prostate cancer as a dedifferentiated organ: androgen receptor, cancer stem cells, and cancer stemness

Open Access
Xiaozhuo Liu, Wen (Jess) Li, Igor Puzanov, David W. Goodrich, Gurkamal Chatta, Dean G. Tang
Journal: Essays in Biochemistry
Essays Biochem (2022) 66 (4): 291–303.
https://doi.org/10.1042/EBC20220003
Published: 16 September 2022
View articletitled, Prostate cancer as a dedifferentiated organ: androgen receptor, cancer stem cells, and cancer stemness
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Articles

Biomechanics of cancer stem cells

Open Access
Xi Chen, Kai Tang, Xueyi Li, Cunyu Zhang, Ying Xin, Keming Li, Youhua Tan
Journal: Essays in Biochemistry
Essays Biochem (2022) 66 (4): 359–369.
https://doi.org/10.1042/EBC20220014
Published: 16 September 2022
View articletitled, Biomechanics of cancer stem cells
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Articles

Panoramic view of microRNAs in regulating cancer stem cells

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Yongzhi Zhao, Danduo Wei, Yitong Zhang, Junfang Ji
Journal: Essays in Biochemistry
Essays Biochem (2022) 66 (4): 345–358.
https://doi.org/10.1042/EBC20220007
Published: 16 September 2022
View articletitled, Panoramic view of microRNAs in regulating cancer stem cells
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Articles

Lipids and the cancer stemness regulatory system in acute myeloid leukemia

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Isabel N.X. Lim, Murtaza S. Nagree, Stephanie Z. Xie
Journal: Essays in Biochemistry
Essays Biochem (2022) 66 (4): 333–344.
https://doi.org/10.1042/EBC20220028
Published: 16 September 2022
View articletitled, Lipids and the cancer stemness regulatory system in acute myeloid leukemia
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Articles

Stochastic population dynamics of cancer stemness and adaptive response to therapies

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Paras Jain, Atchuta Srinivas Duddu, Mohit Kumar Jolly
Journal: Essays in Biochemistry
Essays Biochem (2022) 66 (4): 387–398.
https://doi.org/10.1042/EBC20220038
Published: 16 September 2022
View articletitled, Stochastic population dynamics of cancer stemness and adaptive response to therapies
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Articles

A special issue of Essays in Biochemistry on cancer stem cells

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Fan Ying, Terence Kin Wah Lee
Journal: Essays in Biochemistry
Essays Biochem (2022) 66 (4): 287–289.
https://doi.org/10.1042/EBC20220049
Published: 16 September 2022
View articletitled, A special issue of Essays in Biochemistry on cancer stem cells
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Articles

Targeting protein kinases in cancer stem cells

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Chin Ngok Chu, Terence Kin Wah Lee
Journal: Essays in Biochemistry
Essays Biochem (2022) 66 (4): 399–412.
https://doi.org/10.1042/EBC20220002
Published: 16 September 2022
View articletitled, Targeting protein kinases in cancer stem cells
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Articles

IDH mutation and cancer stem cell

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Yang Zhang, Yang Liu, Fengchao Lang, Chunzhang Yang
Journal: Essays in Biochemistry
Essays Biochem (2022) 66 (4): 413–422.
https://doi.org/10.1042/EBC20220008
Published: 16 September 2022
View articletitled, IDH mutation and cancer stem cell
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Articles

Oncofetal proteins and cancer stem cells

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Qian Yan, Xiaona Fang, Chenxi Li, Ping Lan, Xinyuan Guan
Journal: Essays in Biochemistry
Essays Biochem (2022) 66 (4): 423–433.
https://doi.org/10.1042/EBC20220025
Published: 16 September 2022
View articletitled, Oncofetal proteins and cancer stem cells
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Articles

CRISPR screening in cancer stem cells

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Bei Wang, Alan S.L. Wong
Journal: Essays in Biochemistry
Essays Biochem (2022) 66 (4): 305–318.
https://doi.org/10.1042/EBC20220009
Published: 16 September 2022
View articletitled, CRISPR screening in cancer stem cells
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Articles

Case Study: Implementation and evaluation of a team-based authentic research project module for large cohorts

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Torben Lund, Rosemary K. Clyne
Journal: Essays in Biochemistry
Essays Biochem (2022) 66 (1): 45–51.
https://doi.org/10.1042/EBC20210053
Published: 29 April 2022
View articletitled, Case Study: Implementation and evaluation of a team-based authentic research project module for large cohorts
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Articles

Uptake of formative feedback: perspective from a transnational education cohort

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Sabita Menon, Rosemary K. Clyne
Journal: Essays in Biochemistry
Essays Biochem (2022) 66 (1): 75–81.
https://doi.org/10.1042/EBC20210052
Published: 29 April 2022
View articletitled, Uptake of formative feedback: perspective from a transnational education cohort
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Articles

The physiological role of estrogen receptor functional domains

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Yukitomo Arao, Kenneth S. Korach
Journal: Essays in Biochemistry
Essays Biochem (2021) 65 (6): 867–875.
https://doi.org/10.1042/EBC20200167
Published: 26 November 2021
View articletitled, The physiological role of estrogen receptor functional domains
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Articles

Progesterone receptors in normal breast development and breast cancer

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Sebastian Giulianelli, Caroline A. Lamb, Claudia Lanari
Journal: Essays in Biochemistry
Essays Biochem (2021) 65 (6): 951–969.
https://doi.org/10.1042/EBC20200163
Published: 26 November 2021
View articletitled, Progesterone receptors in normal breast development and breast cancer
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Articles

Orphan nuclear receptor 4A1 (NR4A1) and novel ligands

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Stephen Safe, Rupesh Shrestha, Kumaravel Mohankumar
Journal: Essays in Biochemistry
Essays Biochem (2021) 65 (6): 877–886.
https://doi.org/10.1042/EBC20200164
Published: 26 November 2021
View articletitled, Orphan nuclear receptor 4A1 (NR4A1) and novel ligands
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Articles

Stress sensing within the breast tumor microenvironment: how glucocorticoid receptors live in the moment

Open Access
Carlos Perez Kerkvliet, Thu H. Truong, Julie Hanson Ostrander, Carol A. Lange
Journal: Essays in Biochemistry
Essays Biochem (2021) 65 (6): 971–983.
https://doi.org/10.1042/EBC20200165
Published: 26 November 2021
View articletitled, Stress sensing within the breast tumor microenvironment: how glucocorticoid receptors live in the moment
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