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Articles

Optogenetic control of T cells for immunomodulation

Open Access
Brendan McKee, Siyao Liu, Pauline X. Cai, Zimo Yang, Tien-Hung Lan, Yubin Zhou
Journal: Essays in Biochemistry
Essays Biochem (2025) EBC20253014.
https://doi.org/10.1042/EBC20253014
Published: 23 June 2025
View articletitled, Optogenetic control of T cells for immunomodulation
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Articles

Engineered bacteria and bacterial derivatives as advanced therapeutics for inflammatory bowel disease

Open Access
Jingyuan Wu, Wanlin Ye, Jie Yu, Tuoyu Zhou, Nuo Zhou, Dennis K.P. Ng, Zhaoting Li
Journal: Essays in Biochemistry
Essays Biochem (2025) EBC20253003.
https://doi.org/10.1042/EBC20253003
Published: 27 February 2025
View articletitled, Engineered bacteria and bacterial derivatives as advanced therapeutics for inflammatory bowel disease
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Articles

Phage-specific antibodies: are they a hurdle for the success of phage therapy?

Open Access
Ayaka Washizaki, Arata Sakiyama, Hiroki Ando
Journal: Essays in Biochemistry
Essays Biochem (2024) 68 (5): 633–644.
https://doi.org/10.1042/EBC20240024
Published: 17 December 2024
View articletitled, Phage-specific antibodies: are they a hurdle for the success of phage therapy?
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Articles

Plant proteostasis: a proven and promising target for crop improvement

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Frederica L. Theodoulou, Beatriz Orosa-Puente, Marco Trujillo, Vicente Rubio
Journal: Essays in Biochemistry
Essays Biochem (2022) 66 (2): 75–85.
https://doi.org/10.1042/EBC20210078
Published: 05 August 2022
View articletitled, Plant proteostasis: a proven and promising target for crop improvement
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Articles

Principles of synthetic biology

Open Access
Kathryn L. Garner
Journal: Essays in Biochemistry
Essays Biochem (2021) 65 (5): 791–811.
https://doi.org/10.1042/EBC20200059
Published: 02 November 2021
View articletitled, Principles of synthetic biology
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Articles

Lactic acid bacteria: little helpers for many human tasks

Available to Purchase
Michael Sauer, Nam Soo Han
Journal: Essays in Biochemistry
Essays Biochem (2021) 65 (2): 163–171.
https://doi.org/10.1042/EBC20200133
Published: 26 July 2021
View articletitled, Lactic acid bacteria: little helpers for many human tasks
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Articles

Acinetobacter baylyi ADP1—naturally competent for synthetic biology

Available to Purchase
Suvi Santala, Ville Santala
Journal: Essays in Biochemistry
Essays Biochem (2021) 65 (2): 309–318.
https://doi.org/10.1042/EBC20200136
Published: 26 July 2021
View articletitled, Acinetobacter baylyi ADP1—naturally competent for synthetic biology
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Articles

Metabolic engineering of Vibrio natriegens

Open Access
Felix Thoma, Bastian Blombach
Journal: Essays in Biochemistry
Essays Biochem (2021) 65 (2): 381–392.
https://doi.org/10.1042/EBC20200135
Published: 26 July 2021
View articletitled, Metabolic engineering of Vibrio natriegens
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Articles

Perspectives for the application of Ustilaginaceae as biotech cell factories

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Nick Wierckx, Katharina Miebach, Nina Ihling, Kai P. Hussnaetter, Jochen Büchs, Kerstin Schipper
Journal: Essays in Biochemistry
Essays Biochem (2021) 65 (2): 365–379.
https://doi.org/10.1042/EBC20200141
Published: 26 July 2021
View articletitled, Perspectives for the application of Ustilaginaceae as biotech cell factories
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Articles

So you want to express your protein in Escherichia coli ?

Open Access
Aatir A. Tungekar, Angel Castillo-Corujo, Lloyd W. Ruddock
Journal: Essays in Biochemistry
Essays Biochem (2021) 65 (2): 247–260.
https://doi.org/10.1042/EBC20200170
Published: 26 July 2021
View articletitled, So you want to express your protein in Escherichia coli ?
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Articles

Recombinant protein secretion by Bacillus subtilis and Lactococcus lactis : pathways, applications, and innovation potential

Open Access
Jolanda Neef, Jan Maarten van Dijl, Girbe Buist
Journal: Essays in Biochemistry
Essays Biochem (2021) 65 (2): 187–195.
https://doi.org/10.1042/EBC20200171
Published: 26 July 2021
View articletitled, Recombinant protein secretion by Bacillus subtilis and Lactococcus lactis : pathways, applications, and innovation potential
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Includes: Supplementary data
Articles

Escherichia coli as a platform microbial host for systems metabolic engineering

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Dongsoo Yang, Cindy Pricilia Surya Prabowo, Hyunmin Eun, Seon Young Park, In Jin Cho, Song Jiao, Sang Yup Lee
Journal: Essays in Biochemistry
Essays Biochem (2021) 65 (2): 225–246.
https://doi.org/10.1042/EBC20200172
Published: 26 July 2021
View articletitled, Escherichia coli as a platform microbial host for systems metabolic engineering
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Articles

The Design-Build-Test-Learn cycle for metabolic engineering of Streptomycetes

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Christopher M. Whitford, Pablo Cruz-Morales, Jay D. Keasling, Tilmann Weber
Journal: Essays in Biochemistry
Essays Biochem (2021) 65 (2): 261–275.
https://doi.org/10.1042/EBC20200132
Published: 26 July 2021
View articletitled, The Design-Build-Test-Learn cycle for metabolic engineering of Streptomycetes
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Articles

Established tools and emerging trends for the production of recombinant proteins and metabolites in Pichia pastoris

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Sonakshi De, Diethard Mattanovich, Pau Ferrer, Brigitte Gasser
Journal: Essays in Biochemistry
Essays Biochem (2021) 65 (2): 293–307.
https://doi.org/10.1042/EBC20200138
Published: 26 July 2021
View articletitled, Established tools and emerging trends for the production of recombinant proteins and metabolites in Pichia pastoris
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Articles

Production of proteins and commodity chemicals using engineered Bacillus subtilis platform strain

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Quanwei Zhang, Yaokang Wu, Mengyue Gong, Hongzhi Zhang, Yanfeng Liu, Xueqin Lv, Jianghua Li, Guocheng Du, Long Liu
Journal: Essays in Biochemistry
Essays Biochem (2021) 65 (2): 173–185.
https://doi.org/10.1042/EBC20210011
Published: 26 July 2021
View articletitled, Production of proteins and commodity chemicals using engineered Bacillus subtilis platform strain
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Articles

Harnessing the yeast Saccharomyces cerevisiae for the production of fungal secondary metabolites

Open Access
Guokun Wang, Douglas B. Kell, Irina Borodina
Journal: Essays in Biochemistry
Essays Biochem (2021) 65 (2): 277–291.
https://doi.org/10.1042/EBC20200137
Published: 26 July 2021
View articletitled, Harnessing the yeast Saccharomyces cerevisiae for the production of fungal secondary metabolites
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Articles

Advances in metabolic engineering of Corynebacterium glutamicum to produce high-value active ingredients for food, feed, human health, and well-being

Open Access
Sabrina Wolf, Judith Becker, Yota Tsuge, Hideo Kawaguchi, Akihiko Kondo, Jan Marienhagen, Michael Bott, Volker F. Wendisch, Christoph Wittmann
Journal: Essays in Biochemistry
Essays Biochem (2021) 65 (2): 197–212.
https://doi.org/10.1042/EBC20200134
Published: 26 July 2021
View articletitled, Advances in metabolic engineering of Corynebacterium glutamicum to produce high-value active ingredients for food, feed, human health, and well-being
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Articles

Towards robust Pseudomonas cell factories to harbour novel biosynthetic pathways

Open Access
Nora Lisa Bitzenhofer, Luzie Kruse, Stephan Thies, Benedikt Wynands, Thorsten Lechtenberg, Jakob Rönitz, Ekaterina Kozaeva, Nicolas Thilo Wirth, Christian Eberlein, Karl-Erich Jaeger, Pablo Iván Nikel, Hermann J. Heipieper, Nick Wierckx, Anita Loeschcke
Journal: Essays in Biochemistry
Essays Biochem (2021) 65 (2): 319–336.
https://doi.org/10.1042/EBC20200173
Published: 26 July 2021
View articletitled, Towards robust Pseudomonas cell factories to harbour novel biosynthetic pathways
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Articles

Microbial cell factories: a biotechnology journey across species

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Pablo I. Nikel, Diethard Mattanovich
Journal: Essays in Biochemistry
Essays Biochem (2021) 65 (2): 143–145.
https://doi.org/10.1042/EBC20210037
Published: 26 July 2021
View articletitled, Microbial cell factories: a biotechnology journey across species
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Articles

Construction and analysis of artificial chromosomes with de novo holocentromeres in Caenorhabditis elegans

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Zhongyang Lin, Karen Wing Yee Yuen
Journal: Essays in Biochemistry
Essays Biochem (2020) 64 (2): 233–249.
https://doi.org/10.1042/EBC20190067
Published: 05 August 2020
View articletitled, Construction and analysis of artificial chromosomes with de novo holocentromeres in Caenorhabditis elegans
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Articles

Centromere identity and function put to use: construction and transfer of mammalian artificial chromosomes to animal models

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Ye Yang, Michael A. Lampson, Ben E. Black
Journal: Essays in Biochemistry
Essays Biochem (2020) 64 (2): 185–192.
https://doi.org/10.1042/EBC20190071
Published: 05 June 2020
View articletitled, Centromere identity and function put to use: construction and transfer of mammalian artificial chromosomes to animal models
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Articles

Harnessing targeted DNA methylation and demethylation using dCas9

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Christian Pflueger, Tessa Swain, Ryan Lister
Journal: Essays in Biochemistry
Essays Biochem (2019) 63 (6): 813–825.
https://doi.org/10.1042/EBC20190029
Published: 14 November 2019
View articletitled, Harnessing targeted DNA methylation and demethylation using dCas9
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Articles

Genome-driven cell engineering review: in vivo and in silico metabolic and genome engineering

Open Access
Sophie Landon, Joshua Rees-Garbutt, Lucia Marucci, Claire Grierson
Journal: Essays in Biochemistry
Essays Biochem (2019) 63 (2): 267–284.
https://doi.org/10.1042/EBC20180045
Published: 26 June 2019
View articletitled, Genome-driven cell engineering review: in vivo and in silico metabolic and genome engineering
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Articles

Using genetically incorporated unnatural amino acids to control protein functions in mammalian cells

Open Access
Alexander R. Nödling, Luke A. Spear, Thomas L. Williams, Louis Y.P. Luk, Yu-Hsuan Tsai
Journal: Essays in Biochemistry
Essays Biochem (2019) 63 (2): 237–266.
https://doi.org/10.1042/EBC20180042
Published: 15 May 2019
View articletitled, Using genetically incorporated unnatural amino acids to control protein functions in mammalian cells
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Articles

Non-photosynthetic plastids as hosts for metabolic engineering

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Silas Busck Mellor, James B.Y.H. Behrendorff, Agnieszka Zygadlo Nielsen, Poul Erik Jensen, Mathias Pribil
Journal: Essays in Biochemistry
Essays Biochem (2018) 62 (1): 41–50.
https://doi.org/10.1042/EBC20170047
Published: 27 February 2018
View articletitled, Non-photosynthetic plastids as hosts for metabolic engineering
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Articles

Repurposing proteins for new bioinorganic functions

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Lewis A. Churchfield, Athira George, F. Akif Tezcan
Journal: Essays in Biochemistry
Essays Biochem (2017) 61 (2): 245–258.
https://doi.org/10.1042/EBC20160068
Published: 09 May 2017
View articletitled, Repurposing proteins for new bioinorganic functions
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Articles

Properties of alternative microbial hosts used in synthetic biology: towards the design of a modular chassis

Open Access
Juhyun Kim, Manuel Salvador, Elizabeth Saunders, Jaime González, Claudio Avignone-Rossa, Jose Ignacio Jiménez
Journal: Essays in Biochemistry
Essays Biochem (2016) 60 (4): 303–313.
https://doi.org/10.1042/EBC20160015
Published: 30 November 2016
View articletitled, Properties of alternative microbial hosts used in synthetic biology: towards the design of a modular chassis
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Articles

Synthetic biology and the prospects for responsible innovation

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Phil Macnaghten, Richard Owen, Roland Jackson
Journal: Essays in Biochemistry
Essays Biochem (2016) 60 (4): 347–355.
https://doi.org/10.1042/EBC20160048
Published: 30 November 2016
View articletitled, Synthetic biology and the prospects for responsible innovation
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Articles

Societal impact of synthetic biology: responsible research and innovation (RRI)

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Daniel Gregorowius, Anna Deplazes-Zemp
Journal: Essays in Biochemistry
Essays Biochem (2016) 60 (4): 371–379.
https://doi.org/10.1042/EBC20160039
Published: 30 November 2016
View articletitled, Societal impact of synthetic biology: responsible research and innovation (RRI)
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Articles

Construction of a minimal genome as a chassis for synthetic biology

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Bong Hyun Sung, Donghui Choe, Sun Chang Kim, Byung-Kwan Cho
Journal: Essays in Biochemistry
Essays Biochem (2016) 60 (4): 337–346.
https://doi.org/10.1042/EBC20160024
Published: 30 November 2016
View articletitled, Construction of a minimal genome as a chassis for synthetic biology
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Articles

Towards designing new nano-scale protein architectures

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Jana Aupič, Fabio Lapenta, Žiga Strmšek, Roman Jerala
Journal: Essays in Biochemistry
Essays Biochem (2016) 60 (4): 315–324.
https://doi.org/10.1042/EBC20160018
Published: 30 November 2016
View articletitled, Towards designing new nano-scale protein architectures
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Articles

Synthetic biology approaches to biological containment: pre-emptively tackling potential risks

Open Access
Leticia Torres, Antje Krüger, Eszter Csibra, Edoardo Gianni, Vitor B. Pinheiro
Journal: Essays in Biochemistry
Essays Biochem (2016) 60 (4): 393–410.
https://doi.org/10.1042/EBC20160013
Published: 30 November 2016
View articletitled, Synthetic biology approaches to biological containment: pre-emptively tackling potential risks
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Articles

Synthetic biology routes to bio-artificial intelligence

Open Access
Darren N. Nesbeth, Alexey Zaikin, Yasushi Saka, M. Carmen Romano, Claudiu V. Giuraniuc, Oleg Kanakov, Tetyana Laptyeva
Journal: Essays in Biochemistry
Essays Biochem (2016) 60 (4): 381–391.
https://doi.org/10.1042/EBC20160014
Published: 30 November 2016
View articletitled, Synthetic biology routes to bio-artificial intelligence
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Articles

Agent-based modelling in synthetic biology

Open Access
Thomas E. Gorochowski
Journal: Essays in Biochemistry
Essays Biochem (2016) 60 (4): 325–336.
https://doi.org/10.1042/EBC20160037
Published: 30 November 2016
View articletitled, Agent-based modelling in synthetic biology
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